Adaklin cream 0.1%, 30 g

Acne.

Outwardly.

Before applying the cream, you need to cleanse and dry your skin. With a light touch, evenly apply the cream to the affected surface 1 time / day. before bedtime, avoiding contact with the mucous membranes of the eyes and lips.

The therapeutic effect develops after 4-8 weeks of treatment, persistent improvement occurs after 3 months of treatment. In some cases, due to short-term skin irritation, treatment may be suspended until signs of irritation disappear.

A second course of treatment is possible after consulting a doctor.

1 g of cream contains:
active substance: adapalene 1 mg.
excipients: methyldextrose stearate 35 mg, macrogol (20) 35 mg, squalane (natural) 60 mg, methyl parahydroxybenzoate 2 mg, propyl parahydroxybenzoate 1 mg, disodium edetate 1 mg, phenoxyethanol 5 mg, glycerol 30 mg, carbomer (934–) 4 mg, cyclomethicone 130 mg, sodium hydroxide 0.5 mg.

Pregnancy;

Lactation period (breastfeeding);

Hypersensitivity to the components of the drug;

Children under 12 years of age;

With caution
The drug should be used with caution in dermatitis, eczema, seborrhea.

Tradename:

Adaklin

International non-proprietary name:

Adapalen

Dosage form:

cream for external use

Composition:

1 g of cream contains:
active substance: adapalene 1 mg.
excipients: methyldextrose stearate 35 mg, macrogol (20) 35 mg, squalane (natural) 60 mg, methyl parahydroxybenzoate 2 mg, propyl parahydroxybenzoate 1 mg, disodium edetate 1 mg, phenoxyethanol 5 mg, glycerol 30 mg, carbomer (934–) 4 mg, cyclomethicone 130 mg, sodium hydroxide 0.5 mg.

Description:

Homogeneous cream of white or almost white color.

Pharmacotherapeutic group:

Acne rash treatment remedy. Retinoid.

Pharmacological properties

Pharmacodynamics:
Drug for external use.

Adapalene is a retinoid metabolite, has a comedolytic and anti-inflammatory effect, normalizes the processes of keratinization and epidermal differentiation.

The mechanism of action of adapalene is based on interaction with specific ?-receptors of epidermal skin cells. As a result of the action of adapalene, in particular, there is a decrease in the 'cohesion' of epithelial cells at the mouth of the sebaceous hair follicle and a decrease in the prerequisites for the formation of microcomedones.

Adapalene has an anti-inflammatory effect in vitro and in vivo, acting on inflammatory factors by inhibiting the migration of leukocytes in the focus of inflammation and the metabolism of arachidonic acid.

Pharmacokinetics:
Absorption: absorption of adapalene through the skin is very low (about 4% of the applied dose).

Excretion: the elimination of adapalene from the body occurs mainly with bile.

Indications for use:

acne.

Contraindications:

pregnancy;

lactation period (breastfeeding);

hypersensitivity to drug components;

children under 12 years of age;

With caution
The drug should be used with caution in dermatitis, eczema, seborrhea.

Application during pregnancy and during breastfeeding

It is not recommended to use the drug during pregnancy and lactation (breastfeeding).

Method of administration and dosage

Outwardly.

Before applying the cream, you need to cleanse and dry your skin. With a light touch, evenly apply the cream to the affected surface 1 time / day. before bedtime, avoiding contact with the mucous membranes of the eyes and lips.

The therapeutic effect develops after 4-8 weeks of treatment, persistent improvement occurs after 3 months of treatment. In some cases, due to short-term skin irritation, treatment may be suspended until signs of irritation disappear.

A second course of treatment is possible after consulting a doctor.

Overdose

An overdose of the drug is unlikely.

Side effect

Dermatological reactions: skin irritation, flushing and peeling of the skin at the site of application (treatment must be suspended until skin irritation disappears or the frequency of application must be reduced).

Interaction with other medicinal products

Since adapalene does not interact with oxygen and is not destroyed by light, it is possible to simultaneously treat acne with drugs such as clindamycin or benzoyl peroxide.

special instructions

In case of accidental contact of the drug on the mucous membranes of the eyes, mouth or nose, rinse thoroughly with warm water.

Direct sunlight should be avoided as skin irritation may occur. Treatment can be continued if sun exposure is minimized through the use of sunglasses and hats.

The simultaneous use of cosmetics with drying and irritating effect on the skin (for example, perfume or ethanol-containing products) is not recommended.

Adapalene applied to the skin in the evening can be combined with acne medications applied in the morning.

Release form:

Cream for external use 0.1%.
30 g of cream in an aluminum tube with a latex strip and a protective membrane on the hole, with a screw cap with a rod for opening the protective membrane. 1 tube with instructions for use in a cardboard box.

Shelf life

2 years.
Do not use after the expiration date.

Storage conditions

At a temperature not higher than 25 ? C.
Keep out of the reach of children.

Vacation conditions:

without recipe.