Akriderm Genta cream, 15 g

Dermatitis (simple and allergic), especially secondarily infected, eczema (atopic, children's, coin-like), atopic dermatitis (diffuse neurodermatitis), simple chronic lichen (limited neurodermatitis), solar dermatitis, exfoliative dermatitis, radiation dermatitis, diaper rash, psoriasis, pruritus.

Outwardly. AkridermЃ GENTA is applied in a thin layer to the affected skin area 2 times a day - in the morning and in the evening. A different frequency of use can be established by a doctor, based on the severity of the disease. In mild cases, it is sufficient to apply the cream, as a rule, once a day; more severe lesions may require more frequent use.

The duration of treatment depends on the effectiveness and tolerability of therapy and is 2-4 weeks.

If clinical improvement does not occur, the diagnosis must be clarified.

1 g of cream contains: active substances: betamethasone dipropionate 0.64 mg and gentamicin sulfate 1 mg; excipients: nipagin, propylene glycol, vaseline oil, macrogol cetostearyl ether, cetostearyl alcohol, disodium ethylenediamine tetraacetate, sodium phosphate disubstituted, potassium phosphate monosubstituted, purified water.

Hypersensitivity to any of the components of the drug, skin tuberculosis, skin manifestations of syphilis, chickenpox, herpes simplex, post-vaccination skin reactions, open wounds, lactation and children under 1 year of age.

Trade name of the drug: AkridermЃ GENTA

Dosage form:

cream for external use.

Composition:

1 g of cream contains: active substances: betamethasone dipropionate 0.64 mg and gentamicin sulfate 1 mg; excipients: nipagin, propylene glycol, vaseline oil, macrogol cetostearyl ether, cetostearyl alcohol, disodium ethylenediamine tetraacetate, sodium phosphate disubstituted, potassium phosphate monosubstituted, purified water.

Description: white or almost white cream.

Pharmacotherapeutic group:

antibiotic aminoglycoside + glucocorticosteroid.

ATX code: D07CC01.

Pharmacological properties

Combined preparation for external use with anti-inflammatory, anti-allergic and antibacterial effects.

Betamethasone dipropionate is a glucocorticosteroid that has anti-inflammatory, anti-allergic, anti-exudative and antipruritic effects. It inhibits the accumulation of leukocytes, the release of lysosomal enzymes and pro-inflammatory mediators in the focus of inflammation, inhibits phagocytosis, reduces vascular tissue permeability, and prevents the formation of inflammatory edema.

Gentamicin is a broad-spectrum antibiotic from the aminoglycoside group. It has a bactericidal effect against pathogens of primary and secondary bacterial skin infections. Active against gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae ; gram-positive bacteria: Streptococcus spp. (sensitive strains of group A beta and alpha hemolytic streptococcus), Staphylococcus spp. (coagulase-positive, coagulase-negative and some strains producing penicillinase). Inactive against anaerobes, fungi and viruses.

Indications for use

Dermatitis (simple and allergic), especially secondarily infected, eczema (atopic, children's, coin-like), atopic dermatitis (diffuse neurodermatitis), simple chronic lichen (limited neurodermatitis), solar dermatitis, exfoliative dermatitis, radiation dermatitis, diaper rash, psoriasis, pruritus.

Contraindications

Hypersensitivity to any of the components of the drug, skin tuberculosis, skin manifestations of syphilis, chickenpox, herpes simplex, post-vaccination skin reactions, open wounds, lactation and children under 1 year of age.

Application during pregnancy and lactation

The safety of topical use of glucocorticosteroids in pregnant women has not been established; the prescription of drugs of this group during pregnancy is justified only if the potential benefit outweighs the possible risk. During pregnancy, drugs in this group should not be used in high doses or for a long time. It has not been established whether local use of glucocorticosteroids can cause them to appear in mother's milk, so the issue of stopping breastfeeding should be resolved.

Method of administration and dosage

Outwardly. AkridermЃ GENTA is applied in a thin layer to the affected skin area 2 times a day - in the morning and in the evening. A different frequency of use can be established by a doctor, based on the severity of the disease. In mild cases, it is sufficient to apply the cream, as a rule, once a day; more severe lesions may require more frequent use.

The duration of treatment depends on the effectiveness and tolerability of therapy and is 2-4 weeks.

If clinical improvement does not occur, the diagnosis must be clarified.

Side effect

With topical application of glucocorticosteroids, there may be observed: burning, irritation, dry skin, folliculitis, hypertrichosis, acne-like rashes, hypopigmentation, perioral dermatitis, allergic contact dermatitis. With prolonged use, as well as the use of occlusive dressings, skin maceration, secondary infection, skin atrophy, prickly heat, purpura. When applied to large body surfaces, mainly in children, systemic side effects of glucocorticosteroids (hyperglycemia, glucosuria, reversible suppression of adrenal cortex function, manifestation of Cushing's syndrome) and gentamicin (nephrotoxic and ototoxic effects) are possible.

If you experience adverse reactions that are not described in the instructions, you should consult a doctor.

Overdose

Acute overdose is unlikely, however, with excessive or prolonged use of the drug, chronic overdose is possible, accompanied by signs of hypercortisolism: hyperglycemia, glucosuria, reversible suppression of adrenal cortex function, manifestation of Cushing's syndrome.

Treatment. Appropriate symptomatic treatment is indicated. In the case of chronic toxic effects, gradual withdrawal of the drug is recommended.

Interaction with other medicinal products

The interaction of the drug with other drugs has not been identified.

special instructions

If there are signs of hypersensitivity or skin irritation associated with the use of the drug, treatment should be discontinued and the patient should be selected for adequate therapy. With prolonged treatment, when the drug is applied to extensive skin surfaces, when using occlusive dressings, as well as in children, systemic absorption of glucocorticosteroids is possible. For children from 1 year old, the drug is prescribed only according to strict indications and under medical supervision, since systemic side effects associated with betamethasone may develop. When using the drug on large surfaces and / or under an occlusive dressing, it is possible to suppress the function of the hypothalamic-pituitary-adrenal system and develop symptoms of hypercortisolism, there may be a decrease in the excretion of growth hormone, an increase in intracranial pressure. On the skin of the face more often,than on other surfaces of the body, after long-term treatment with topical glucocorticosteroids, atrophic changes may appear; the course of treatment in this case should not exceed 5 days. AkridermЃ GENTA is not intended for use in ophthalmology. Avoid contact with eyes.

With prolonged use of the drug, its cancellation should be carried out gradually.

Release form
Cream for external use, 15 or 30 g in an aluminum tube. Each tube, together with instructions for use, is placed in a cardboard box.

Storage conditions
At a temperature of 15 to 25 ? C, out of the reach of children.

Shelf life is
2 years. The drug should not be used after the expiration date indicated on the package.

Terms of dispensing from pharmacies
Without prescription.