Allopurinol | Allopurinol-Aegis tablets 100 mg 50 pcs

Latin name

ALLOPURINOL-EGIS

Packing

50 pcs

Pharmacological action

Means that violate the synthesis of uric acid. Allopurinol is a structural analogue of hypoxanthine. It inhibits the xanthine oxidase enzyme, which is involved in the conversion of hypoxanthine to xanthine and xanthine to uric acid. This is due to a decrease in the concentration of uric acid and its salts in body fluids and urine, which helps to dissolve existing urate deposits and prevents their formation in tissues and kidneys. When taking Allopurinol, urinary excretion of hypoxanthine and xanthine increases.

Indications

Treatment and prevention of gout and hyperuricemia of any genesis (including in combination with nephrolithiasis, renal failure, urate nephropathy). Recurrent mixed oxalate-calcium kidney stones in the presence of hyperuricosuria. Increased urate formation due to enzymatic disorders. Prevention of acute nephropathy with cytostatic and radiation therapy of tumors and leukemia, as well as with complete therapeutic fasting.

Contraindications

Severe impaired liver and / or kidney function, pregnancy, lactation. Hypersensitivity to allopurinol.

Use during pregnancy and lactation

Allopurinol-Egis is contraindicated for use during pregnancy and lactation.

Composition

1 tablet contains 100 mg of allopurinol

auxiliary ingredients: lactose, starch, polyvidone, talc, magnesium stearate, sodium amylopectin glycolate.

Dosage and administration

Dosage regimen Allopurinol-Egis is set individually, under the control of the concentration of urate and uric acid in the blood and urine. Adults ingestion - 100-900 mg / day, depending on the severity of the disease. The frequency of administration is 2-4 times / day after meals. Children under the age of 15 years - 10-20 mg / kg / day or 100-400 mg / day. Maximum doses: in case of impaired renal function (including due to urate nephropathy) - 100 mg / day. An increase in the dose is possible in cases where, against the background of the therapy, an increased concentration of urates in the blood and urine remains.

Side effects

Nausea, diarrhea, skin rashes, fever are possible.

Drug Interaction

When co-administered with allopurinol, it enhances the action of coumarin anticoagulants, arabinoside adenine, and hypoglycemic drugs (especially in renal dysfunction). Uricosuric agents and salicylates at high doses reduce the activity of allopurinol. When co-administered with allopurinol and cytostatics, myelotoxic activity is more likely than with separate administration. With the simultaneous use of allopurinol and azathioprine or mercaptopurine, the accumulation of the latter in the body is observed, since Due to allopurinol inhibition of xanthine oxidase activity required for biotransformation of drugs, their metabolism and elimination are slowed down.

Overdose

Symptoms: nausea, vomiting, diarrhea, dizziness, oliguria.

Treatment: forced diuresis, hemo-and peritoneal dialysis.

Storage conditions

Store in a dark place at a temperature not exceeding 30 РC.

Deystvuyushtee substance

Allopurinol

Terms and conditions

prescription

Dosage form

tablets



Appointment Appointment

Adult prescribed by a doctor, children on prescription, Children over 3 years old