Antareit chewable tablets 800mg + 40mg, No. 12

Symptoms associated with increased gastric acidity and reflux esophagitis:

• heartburn,

• belching 'sour taste'

• pain in the stomach (appear irregularly),

• a feeling of fullness or heaviness in the epigastric region,

• flatulence,

• dyspepsia (including those caused by an error in diet, medication, alcohol abuse, coffee, nicotine).

Inside. The tablets should be chewed thoroughly or kept in the mouth until they are completely absorbed.

Adults and adolescents over 12 years of age: unless otherwise recommended by a doctor, 1-2 tablets are taken shortly after a meal. If necessary, you can repeat the drug intake after 2 hours.

The maximum daily dose for tablets 400 mg + 20 mg is 16 tablets; for tablets

800 mg + 40 mg - 8 tablets.

Active ingredients:

magaldrat

simethicone

• Hypersensitivity to the components of the drug;

• severe renal failure;

• hypophosphatemia;

• intolerance to fructose (due to the presence of sorbitol in the preparation);

• children under 12 years of age.

With care: in case of renal failure (with prolonged use, an increase in the content of magnesium and aluminum in the blood plasma is possible); with Alzheimer's disease; with a low content of phosphates in food (risk of developing phosphate deficiency).

Pharmacological properties

Pharmacodynamics

Combined drug, the action of which is due to the properties of its constituent components. It has an antacid, absorbent, enveloping, carminative effect.

Magaldrat

Magaldrate (aluminum magnesium hydroxide sulfate) neutralizes free hydrochloric acid in the stomach without causing secondary hypersecretion of gastric juice. Due to the increase in pH, when it is taken, the peptic activity of the gastric juice decreases. It has an absorbent and enveloping effect, due to which the effect of damaging factors on the gastric mucosa is reduced, and binds bile acids.

Simethicone

Simethicone changes the surface tension of gas bubbles formed in the contents of the stomach and intestinal mucus, and causes their destruction. The gases released during this can be absorbed by the cells of the intestinal walls, or excreted due to peristalsis. Simethicone removes foam in a purely physical way, does not enter into chemical reactions, and is pharmacologically inert.

Pharmacokinetics

Magaldrat

The absorption of aluminum and magnesium ions in the blood is low. With normal kidney function, the concentration of aluminum and magnesium in the blood does not change. In patients with chronic renal failure, the content of aluminum and magnesium in the blood can increase to toxic levels as a result of impaired excretion.

Simethicone

Simethicone due to pharmacological and chemical inertness after oral administration is not absorbed into organs and tissues. After passing through the gastrointestinal tract (GIT), it is excreted unchanged by the intestines.

Indications for use

Symptoms associated with increased gastric acidity and reflux esophagitis:

• heartburn,

• belching 'sour taste'

• pain in the stomach (appear irregularly),

• a feeling of fullness or heaviness in the epigastric region,

• flatulence,

• dyspepsia (including those caused by an error in diet, medication, alcohol abuse, coffee, nicotine).

Contraindications

• Hypersensitivity to the components of the drug;

• severe renal failure;

• hypophosphatemia;

• intolerance to fructose (due to the presence of sorbitol in the preparation);

• children under 12 years of age.

With care: in case of renal failure (with prolonged use, an increase in the content of magnesium and aluminum in the blood plasma is possible); with Alzheimer's disease; with a low content of phosphates in food (risk of developing phosphate deficiency).

Application during pregnancy and during breastfeeding

No controlled clinical trials with the study of the use of the drug Antareit in pregnant women have been carried out, however, in preclinical studies, no teratogenic effect or action has been identified. Due to the lack of clinical experience, the use of the drug during pregnancy is possible only if the benefits of its use for the mother outweighs the potential risk to the fetus.

Avoid prescribing the drug during pregnancy in high doses and for a long time.

You do not need to stop breastfeeding while taking Antareit.

Method of administration and dosage

Inside. The tablets should be chewed thoroughly or kept in the mouth until they are completely absorbed.

Adults and adolescents over 12 years of age: unless otherwise recommended by a doctor, 1-2 tablets are taken shortly after a meal. If necessary, you can repeat the drug intake after 2 hours.

The maximum daily dose for tablets 400 mg + 20 mg is 16 tablets; for tablets

800 mg + 40 mg - 8 tablets.

Side effect

Allergic reactions, nausea, vomiting, impaired taste, constipation, diarrhea. With prolonged use in high doses - hypophosphatemia, hypocalcemia, hypercalciuria, osteomalacia, osteoporosis, hypermagnesemia, hyperaluminaemia, encephalopathy, nephrocalcinosis, impaired renal function. In patients with concomitant renal failure, thirst, lowering blood pressure, hyporeflexia.

Overdose

Symptoms: with prolonged use of high doses, the formation of kidney stones, constipation, drowsiness, hypermagnesemia are possible. Signs of metabolic alkalosis can also be observed: mood lability, feeling of numbness or muscle pain, nervousness and fatigue, unpleasant taste sensations.
Treatment: it is necessary to take measures for the rapid elimination of the drug: rinse the stomach, induce vomiting, take activated charcoal.

Interaction with other medicinal products

Antareit reduces and slows down the absorption of digoxin, indomethacin, salicylates, chlorpromazine, phenytoin, H2-histamine blockers, beta-blockers, diflunisal, isoniazid, tetracycline antibiotics, quinolones (ciprofloxacin, drnofloxacinit) , pivampicillin, rifampicin, indirect anticoagulants, barbiturates, fexofenadine, dipyridamole, zalcitabine, bile acids - chenodeoxycholic and ursodeoxycholic, penicillamine, iron and lithium preparations, quinidine, lansoprazole, mexiletine, mexiletine.
M-anticholinergics, slowing down gastric emptying, enhance and lengthen the effect of the drug.

special instructions

With the simultaneous use of Antareit and other medicines, an interval of at least 1-2 hours should be adhered to. With long-term use, you should ensure a sufficient intake of phosphorus from food. With mild to moderate renal impairment, it is necessary to regularly monitor the content of aluminum, calcium, phosphates in the blood plasma. The drug contains sorbitol, which is contraindicated in congenital fructose intolerance.

Features of the effect of the drug on the ability to drive vehicles or when working with potentially dangerous mechanisms

Does not adversely affect the ability to drive vehicles and work with mechanisms that require increased concentration of attention and speed of psychomotor reactions.