Antigrippin-Anvi capsules, No. 20

Symptomatic treatment of influenza, ARVI, 'colds' diseases in adults and adolescents over 15 years old.

The drug is taken orally, after meals, with water, 2-3 times / day for 3-5 days until the symptoms of the disease disappear.

Adults and adolescents over 15 years of age are prescribed 2 capsules per dose: 1 green capsule (from blister A) and 1 white capsule (from blister B).

The patient should be warned that if there is no improvement in well-being, the drug should be discontinued and a doctor should be consulted.

Capsule A

acetylsalicylic acid

vitamin C

rutoside (as trihydrate)

Capsule B

metamizole sodium monohydrate

diphenhydramine hydrochloride

d calcium gluconate monohydrate

• Erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase);

• gastrointestinal bleeding; increased tendency to bleeding;

• bronchial asthma and diseases accompanied by bronchospasm (including 'aspirin' asthma);

• oppression of hematopoiesis (agranulocytosis, neutropenia, leukopenia); severe liver dysfunction;

• severe renal dysfunction; hereditary hemolytic anemia (including those associated with a deficiency of glucose-6-phosphate dehydrogenase);

• hemorrhagic diathesis (hemophilia, von Willebrand disease, telangiectasia, hypoprothrombinemia, thrombocytopenia, thrombocytopenic purpura);

• dissecting aortic aneurysm;

• portal hypertension;

• hypercalcemia (the concentration of calcium ions should not exceed 12 mg% or 6 meq / l);

• hypercalciuria; nephrolithiasis (calcium);

• sarcoidosis;

• intoxication with cardiac glycosides (risk of arrhythmia);

• vitamin K deficiency;

• deficiency of glucose-6-phosphate dehydrogenase;

• pregnancy;

• lactation period (breastfeeding);

• children and adolescents up to 15 years old;

• hypersensitivity to the components of the drug.

• The drug is prescribed with caution for hyperuricemia, urate nephrolithiasis, gout, gastric ulcer and duodenal ulcer (in history), decompensated heart failure.

pharmachologic effect

The drug is a combined composition.

Acetylsalicylic acid has analgesic, antipyretic and anti-inflammatory effects; inhibits platelet aggregation. Ascorbic acid plays an important role in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, and helps to increase the body's resistance.

Rutoside (rutin) is an angioprotective agent. Reduces capillary permeability, reduces swelling and inflammation, strengthens the vascular wall. Inhibits aggregation and increases the degree of deformation of erythrocytes.

Metamizole sodium has an analgesic, antipyretic and weak anti-inflammatory effect, the mechanism of which is associated with the inhibition of prostaglandin synthesis.

Diphenhydramine has antiallergic, decongestant, local anesthetic effect (reduces vascular permeability, eliminates swelling and hyperemia of the nasal mucosa, sore throat and manifestations of allergic reactions from the upper respiratory tract).

Calcium gluconate is a regulator of calcium and phosphorus metabolism, has antiallergic effect (the mechanism is unclear), and reduces vascular permeability. For allergic diseases or conditions, it is recommended to use it together with antihistamines.

Side effect

Allergic reactions: skin rash, Quincke's edema, bronchospasm.

From the urinary system: renal failure.

From the side of the cardiovascular system: increased blood pressure, tachycardia.

From the digestive system: anorexia, nausea, vomiting, gastralgia, diarrhea, erosive and ulcerative lesions of the gastrointestinal tract, gastrointestinal bleeding, liver failure.

Side effects observed with prolonged use of the drug (more than 7 days)

From the side of the central nervous system: dizziness, headache.

From the senses: visual impairment, tinnitus, deafness.

From the hematopoietic system: leukopenia, thrombocytopenia, agranulocytosis.

From the side of the blood coagulation system: decreased platelet aggregation, hypocoagulation, hemorrhagic syndrome (including nosebleeds, bleeding gums, purpura).

On the part of the respiratory system: with a tendency to bronchospasm, an attack may be provoked.

From the urinary system: kidney damage with papillary necrosis, renal dysfunction, oliguria, anuria, proteinuria, interstitial nephritis, urine staining red due to the release of the metabolite.

Allergic reactions: anaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).

Others: in children - Reye's syndrome (hyperpyrexia, metabolic acidosis, disorders of the nervous system and psyche, vomiting, liver dysfunction). The patient should be warned that all side effects, incl. not listed above, you should inform your doctor and stop taking the drug.

Application during pregnancy and lactation

The drug is contraindicated for use during pregnancy. Acetylsalicylic acid has a teratogenic effect: when used in the first trimester of pregnancy, it leads to the development of cleavage of the upper palate; in the third trimester - to the premature closure of the ductus arteriosus in the fetus, which causes hyperplasia of the pulmonary vessels and hypertension in the vessels of the pulmonary circulation, and to inhibition of labor (due to inhibition of prostaglandin synthesis). Acetylsalicylic acid is excreted in breast milk, which increases the risk of bleeding in a child due to dysfunction of platelets. If necessary, the appointment during lactation should stop breastfeeding for the period of use of the drug.

Application for violations of liver function

Contraindicated in severe liver dysfunction and portal hypertension.

Application for impaired renal function

Contraindicated in severe renal impairment, nephrolithiasis (calcium). The drug is prescribed with caution for urate nephrolithiasis.

Application in children

The use of the drug is contraindicated in children and adolescents under 15 years of age.

special instructions

With prolonged use of the drug, it is necessary to monitor the picture of peripheral blood and laboratory indicators of the functional state of the liver.

Since acetylsalicylic acid has an antiplatelet effect, the patient, if he is to undergo surgery, must warn the doctor in advance about taking the drug.

Acetylsalicylic acid in low doses reduces the excretion of uric acid, which can in some cases trigger a gout attack.

While using the drug, patients should avoid drinking alcoholic beverages due to the increased risk of gastrointestinal bleeding.

Due to the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor renal function and blood pressure.

The administration of ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors can aggravate the course of the process.

Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (determination of glucose, bilirubin, hepatic transaminase activity, LDH in blood plasma).

In patients with bronchial asthma and hay fever, hypersensitivity reactions may develop when taking the drug.

Use in pediatrics

The drug is not prescribed as an antipyretic agent for children under 15 years of age with acute respiratory viral diseases due to the risk of developing Reye's syndrome (encephalopathy and acute fatty liver disease with acute development of liver failure).

Influence on the ability to drive vehicles and use mechanisms

During the period of use of the drug, one should refrain from engaging in potentially hazardous activities that require increased attention and speed of psychomotor reactions.

Overdose

Symptoms: nausea, vomiting, stomach pain, sweating, pallor of the skin, tachycardia; with a slight overdose - ringing in the ears; with severe overdose - drowsiness, collapse, convulsions, bronchospasm, shortness of breath, anuria, bleeding, progressive respiratory paralysis and respiratory acidosis (due to uncoupling of oxidative phosphorylation).

Treatment: artificial vomiting, gastric lavage, the appointment of saline laxatives, activated carbon; with the development of convulsive syndrome - intravenous administration of diazepam and barbiturates; if necessary - carrying out forced diuresis, hemodialysis.

Drug interactions

With the simultaneous use of Antigrippin-ANVIЃ enhances the effect of heparin, indirect anticoagulants, reserpine, steroid hormones and hypoglycemic agents.

With the simultaneous use of Antigrippin-ANVIЃ reduces the effectiveness of spironolactone, furosemide, antihypertensive and uricosuric drugs. Antigrippin-ANVIЃ enhances the side reactions of GCS, sulfonylurea derivatives, methotrexate, non-narcotic analgesics and NSAIDs.

With the simultaneous use of the drug Antigrippin-ANVIЃ with barbiturates, antiepileptic drugs, zidovudine, rifampicin and alcohol-containing drugs, the risk of hepatotoxic action increases. These combinations should be avoided.

Ascorbic acid improves intestinal absorption of iron preparations.

Tricyclic antidepressants, oral contraceptives and allopurinol interfere with the metabolism of metamizole in the liver and increase its toxicity.

Metamizole sodium enhances the effects of alcoholic beverages.

The simultaneous use of metamizole sodium with cyclosporine reduces the level of the latter in the blood plasma.

When used simultaneously with metamizole sodium, thiamazole and melphalan increase the risk of developing leukopenia.

Sedatives and tranquilizers enhance the analgesic effect of metamizole sodium.

Radiopaque contrast agents, colloidal blood substitutes and penicillin should not be used while using metamizole sodium.