Azithromycin | Azithromycin tablets coated with captivity. 500 mg 3 pcs.

packaging 3 pcs

Pharmacological action

Broad-spectrum antibiotic. It is the first representative of a new subgroup of macrolide antibiotics - azalides. When creating high concentrations of inflammation in the focus, it has a bactericidal effect.

Gram-positive cocci are sensitive to azithromycin: Streptococcus pneumoniae, Str.pyogenes, Str.agalactiae, streptococci of CF and G groups, Staphylococcus aureus, S. viridans gram-negative bacteria: Haemophilus influenzae, Moraxella catarrhalistiss Bordellis, Bordellis pseudoris, Bordellis Bordea, .ducrei, Campylobacter jejuni, Neisseria gonorrhoeae, and Gardnerella vaginalis, some anaerobic microorganisms: Bacteroides bivius, Clostridium perfringens, Peptostreptococcus spp as well as Clamydia trachomatis, Mycoplasma pneumoniae, urelamdrumlama Tremulma bramidlama

Azithromycin is inactive against gram-positive bacteria, erythromycin resistant.

Indications

Upper respiratory tract infections and ENT organs caused by sensitive pathogens: pharyngitis, tonsillitis, laryngitis, sinusitis, otitis media scarlet fever

lower respiratory tract infections: pneumonia (including atypical, bronchitis exacerbation) infections of the skin and soft tissues: erysipelas, impetigo, secondarily infected dermatoses

urinary tract infections: gonorrheic and non-chronic urethritis, cervicitis Lyme disease (initial stage - erythema migrans), gastric ulcer and duodenum tnoj intestine, associated with Helicobacter pylori (as part of combination therapy).

Contraindications

Hypersensitivity (including to other macrolides), hepatic and / or renal failure, lactation.

With caution - pregnancy (can be used in cases where the benefits of its use significantly exceed the risk that always exists when using any drug during pregnancy), arrhythmia (ventricular arrhythmias and prolongation of the QT interval are possible), children under 16 years of age, children with severe impaired liver or kidney function.

Special instructions for

If you miss a dose, you should take the missed dose as soon as possible, and the next with an interval of 24 hours.

You must observe a break of 2 hours while using antacids.

The safety of prescribing azithromycin (iv, as well as capsules and tablets) in children and adolescents under 16 years of age is not completely established (it can be used as an oral suspension in children from 6 months of age and older).

After withdrawal of treatment, hypersensitivity reactions may persist in some patients, which requires specific therapy under the supervision of a physician.

Composition

1 tablet contains:

azithromycin (in the form of a dihydrate) 500 mg.

Dosage and administration

Inside, 1 hour before or 2 hours after meals, 1 time per day.

Adults

For infections of the upper and lower respiratory tract - 0. 5 g / day for 1 dose for 3 days (course dose - 1.5 g).

For infections of the skin and soft tissues - 1 g / day on the first day for 1 dose, then 0.5 g / day daily from 2 to 5 days (course dose - 3 g).

In acute infections of the genitourinary organs (uncomplicated urethritis or cervicitis), once 1 g.

For Lyme disease (borreliosis) for the treatment of stage I (erythema migrans) - 1 g on the first day and 0.5 g daily from 2 to 5 days (course dose - 3 g).

In case of gastric and duodenal ulcer associated with Helicobacter pylori - 1 g / day for 3 days as part of combination anti-Helicobacter therapy.

Children are prescribed at a rate of 10 mg / kg once a day for 3 days or on the first day - 10 mg / kg, then 4 days - 5-10 mg / kg / day for 3 days (course dose - 30 mg / kg).

Side effects

From the digestive system: when taken orally - diarrhea (5%), nausea (3%), abdominal pain (3%) 1% or less - dyspepsia, flatulence, vomiting, melena, cholestatic jaundice, increased activity of hepatic transaminases in addition, in children - constipation, anorexia, gastritis candidiasis of the oral mucosa (with iv administration). From the CCC: palpitations, chest pain (1% or less).

From the nervous system: dizziness, headache, vertigo, drowsiness in children - headache (with treatment of otitis media), hyperkinesia, anxiety, neurosis, sleep disturbance (1% or less).

From the genitourinary system: vaginal candidiasis, nephritis (1% or less).

Allergic reactions: rash, photosensitivity, Quincke's edema

Drug interactions

Antacids (aluminum and magnesium), ethanol and food slow down and reduce absorption. With the combined use of warfarin and azithromycin (in usual doses), changes in prothrombin time were not detected, however, given that the interaction of macrolides and warfarin may increase the anticoagulation effect, patients need careful monitoring of prothrombin time.

Digoxin: increased digoxin concentration. Ergotamine and dihydroergotamine: increased toxic effects (vasospasm, dysesthesia).

Triazolam: decreased clearance and increased pharmacological action of triazolan. Slows down the excretion and increases the plasma concentration and toxicity of cycloserine, indirect anticoagulants, methylprednisolone, felodipine, as well as drugs, subjected to microsomal oxidation (carbamazepine, terfenadine, cyclosporine, hexobarbital, ergot alkaloids, valproic acid, disopyramide, bromocriptine phenytoin, phenytoin, oral hypoglycemic agents, theophylline and other xanthine azithomyctomas) - due to hepatocyte azithomycinomas) -

Lincosamines weaken effectiveness, tetracycline and chloramphenicol enhance. Pharmaceutically incompatible with heparin.

Storage conditions

Keep dry, protected from light at a temperature not exceeding 25 РC.

Term hodnosty

2 years

active substance

Azithromycin

Terms leave through pharmacies

In retseptu

lekarstvennaja form

tablets

Prescribing

For adults as prescribed by a doctor