bisoprolol | Aritel tablets is covered.pl.ob. 10 mg 30 pcs.
Special Price
$15.68
Regular Price
$23.00
In stock
SKU
BID483360
Release form
Film-coated tablets.
Film-coated tablets.
Release form
Film-coated tablets.
Packing
30 tablets per pack.
Pharmacological action
Aritel - selective beta1 - adrenergic blocker, without its own sympathomimetic activity, does not have clinically significant membrane stabilizing properties. It reduces the activity of plasma renin, reduces the need for myocardium in oxygen, reduces the heart rate (HR) (at rest and during exercise). It has hypotensive, antiarrhythmic and antianginal effects. By blocking beta1-adrenoreceptors of the heart in low doses, it decreases the formation of cAMP stimulated by catecholamines from ATP, reduces the intracellular current of calcium ions, has a negative chrono-, dromo-, batmo- and inotropic effect, inhibits conduction and excitability, and reduces myocardial contractility.
The antihypertensive effect of Aritel is associated with a decrease in minute blood volume, sympathetic stimulation of peripheral vessels, a decrease in the activity of the renin-angiotensin system (of great importance for patients with initial hypersecretion of renin), restoration of sensitivity in response to a decrease in blood pressure (BP) and effects on the central nervous system (CNS). With arterial hypertension, the effect occurs after 2–5 days, a stable effect - after 1–2 months.
The antianginal effect is due to a decrease in myocardial oxygen demand as a result of a decrease in heart rate and contractility, lengthening of diastole, and improvement of myocardial perfusion. By increasing the final diastolic pressure in the left ventricle and increasing the stretching of the muscle fibers of the ventricles, it can increase the need for oxygen, especially in patients with chronic heart failure.
Antiarrhythmic effect is due to the elimination of arrhythmogenic factors (tachycardia, increased activity of the sympathetic nervous system, increased content of cAMP, arterial hypertension), a decrease in the rate of spontaneous excitation of sinus and ectopic pacemakers and a slowdown in atrioventricular (AV) conduction (mainly in the antegrade and, to a lesser extent, in the retrograde directions through the AV node) and along additional routes.
Indications
Arterial hypertension
Coronary heart disease: prevention of angina attacks.
Contraindications
Hypersensitivity to the components of the drug and other beta-blockers,
Shock (including cardiogenic)
Collapse
Pulmonary edema
Acute heart failure, chronic heart failure in stage II stage II, stage II decompensation. , sinus node weakness syndrome, severe bradycardia, Prinzmetal angina, cardiomegaly (without signs of heart failure), arterial hypotension (systolic blood pressure less than 100 mm Hg, especially with myocardial infarction)
Bronchial asthma and chronic obstructive pulmonary disease history of srdlk monoamine oxidase inhibitors (MAO) (except MAO-B)
Late stages of peripheral circulatory disorders, Raynaud's disease)
Pheochromocytoma (without the simultaneous use of alpha-adrenoblock tori)
Metabolic acidosis
Age 18 years (effectiveness and safety have been established).
Precautions:
liver failure, chronic renal failure
Myasthenia
Thyrotoxicosis
Diabetes mellitus
Atrioventricular block I degree
Depression (including history)
Psoriasis
Elderly.
Use in pregnancy and lactation
Not described.
Special instructions
Monitoring of patients taking Aritel should include measurement of heart rate and blood pressure (daily at the beginning of treatment, then once every 3-4 months), ECG, determination of blood glucose in patients with diabetes mellitus (1 time in 4-5 months). In elderly patients, it is recommended to monitor renal function (1 time in 4-5 months).
Before starting treatment, it is recommended to study the function of external respiration in patients with a history of bronchopulmonary burden.
With the simultaneous administration of clonidine, its administration can be stopped only a few days after the cancellation of Aritel.
Composition
1 tablet contains:
Active substances:
bisoprolol fumarate 10 mg.
Excipients:
Potato starch
Povidone (kollidon-30)
Lactose
Microcrystalline cellulose
Silicon dioxide colloidal
Magnesium steak suldryl oxide
Dosage and Administration
Aritel inside, in the morning on an empty stomach, without chewing, 5 mg once. If necessary, increase the dose to 10 mg once a day. The maximum daily dose is 20 mg / day.
In patients with impaired renal function with creatine clearance less than 20 ml / min or with severe impaired liver function, the maximum daily dose is 10 mg.
Side effects of
From the central nervous system: increased fatigue, weakness, dizziness, headache, sleep disorders, depression, anxiety, confusion or short-term memory loss, hallucinations, asthenia, myasthenia gravis, paresthesia in the limbs (in patients with intermittent "Lameness and Raynaud's syndrome), tremor.
On the part of the sensory organs: impaired vision, decreased secretion of lacrimal fluid, dry and sore eyes, conjunctivitis.
From the cardiovascular system: sinus bradycardia, palpitations, impaired myocardial conduction, AV block (up to the development of complete transverse blockade and cardiac arrest), arrhythmias, weakening myocardial contractility, development (aggravation) of chronic heart failure (swelling of the ankles, feet shortness of breath), decreased blood pressure, orthostatic hypotension, the manifestation of angiospasm (increased disturbance of peripheral circulation, cooling of the lower extremities, Raynaud's syndrome), chest pain.
From the digestive system: dry oral mucosa, nausea, vomiting, abdominal pain, constipation or diarrhea, impaired liver function (dark urine, yellowness of the sclera or skin, cholestasis), taste changes.
From the respiratory system: nasal congestion, difficulty breathing when prescribed in high doses (loss of selectivity) and / or in predisposed patients - laryngo- and bronchospasm.
From the endocrine system: hyperglycemia (in patients with non-insulin-dependent diabetes mellitus), hypoglycemia (in patients receiving insulin), hypothyroid state.
Allergic reactions: pruritus, rash, urticaria.
From the skin: increased sweating, flushing of the skin, exanthema, psoriasis-like skin reactions, exacerbation of symptoms of psoriasis.
Laboratory indicators: thrombocytopenia (unusual bleeding and hemorrhage), agranulocytosis, leukopenia, changes in liver enzyme activity (increased ALT, AST), bilirubin levels, triglycerides.
Effect on the fetus: intrauterine growth retardation, hypoglycemia, bradycardia.
Other: back pain, arthralgia, decreased libido, decreased potency, withdrawal syndrome (increased angina attacks, increased blood pressure).
Drug Interactions
Allergens used for immunotherapy, or allergen extracts for skin tests increase the risk of severe systemic allergic reactions or anaphylaxis in patients receiving bisoprolol.
Iodine-containing radiopaque drugs for intravenous administration increase the risk of anaphylactic reactions.
Phenytoin when administered intravenously, drugs for inhalation general anesthesia (hydrocarbon derivatives) increase the severity of cardiodepressive action and the likelihood of lowering blood pressure.
Aritel alters the effectiveness of insulin and oral hypoglycemic drugs, masks the symptoms of developing hypoglycemia (tachycardia, increased blood pressure). It reduces the clearance of lidocaine and xanthines (except diphillin) and increases their plasma concentration, especially in patients with initially increased theophylline clearance under the influence of smoking.
Non-steroidal anti-inflammatory drugs (delay of Na + and blockade of prostaglandin synthesis by the kidneys) weaken the antihypertensive effect, glucocorticosteroids and estrogens (delay of Na + ions).
Cardiac glycosides, methyldopa, reserpine and guanfacine, “slow” calcium channel blockers (verapamil, diltiazem), amiodoron and other antiarrhythmic drugs increase the risk of developing or worsening bradycardia, AV blockade, heart failure and heart failure.
Nifedipine can lead to a significant decrease in blood pressure.
Diuretics, clonidine, sympatholytics, hydralazine and other antihypertensive drugs can lead to an excessive decrease in blood pressure.
Extends the effect of non-depolarizing muscle relaxants and the anticoagulant effect of coumarins.
Three - and tetracyclic antidepressants, antipsychotic drugs (antipsychotics), ethanol, sedative and hypnotic drugs increase CNS depression.
The simultaneous use with MAO inhibitors is not recommended due to a significant increase in the antihypertensive effect, the break in treatment between taking MAO inhibitors and bisoprolol should be at least 14 days.
Non-hydrogenated ergot alkaloids increase the risk of peripheral circulation disorders.
Ergotamine increases the risk of developing peripheral circulatory disorders sulfasalazine increases the plasma concentration of bisoprolol rifampicin shortens the elimination half-life.
overdose
Symptoms: arrhythmia, ventricular extrasystole, severe bradycardia, AV blockade, severe BP, chronic heart failure , Cyanosis or nail Paltsev palm, zatrudnenye breathing, bronchospasm, dizziness, obmorochn e STATUS, convulsions.
Treatment: gastric lavage and administration of adsorbing drugs symptomatic therapy: with developed AV blockade - intravenous (I / O) 1-2 mg atropine, epinephrine or staging of a temporary pacemaker for ventricular extrasystole - lidocaine (class Ia drugs are not used) in reducing blood pressure - the patient should be in Trendelenburg if there are no signs of pulmonary edema, - intravenous plasma replacement solutions, inefficiency, inefficiency, of chronotropic and inotropic action and elimination of pronounced decrease in blood pressure) in heart failure - cardiac glycosides, diuretics, glucagon in convulsions - intravenous di yawning with bronchospasm - beta2 - adrenostimulants inhalation.
Storage conditions
In a dry, dark place at a temperature not exceeding 25 РC, out of the reach of children.
active substance
bisoprolol
lekarstvennaja form
tablets
Prescribing
For prescribing
for prescribing
for 5 dfp178frd8pf8 adults prescribed by a doctor
Indications
Indications
hypertension, arrhythmia, heart failure
Canonfarma, Russia p19ff6868fonfarmaf7 . Russia
Film-coated tablets.
Packing
30 tablets per pack.
Pharmacological action
Aritel - selective beta1 - adrenergic blocker, without its own sympathomimetic activity, does not have clinically significant membrane stabilizing properties. It reduces the activity of plasma renin, reduces the need for myocardium in oxygen, reduces the heart rate (HR) (at rest and during exercise). It has hypotensive, antiarrhythmic and antianginal effects. By blocking beta1-adrenoreceptors of the heart in low doses, it decreases the formation of cAMP stimulated by catecholamines from ATP, reduces the intracellular current of calcium ions, has a negative chrono-, dromo-, batmo- and inotropic effect, inhibits conduction and excitability, and reduces myocardial contractility.
The antihypertensive effect of Aritel is associated with a decrease in minute blood volume, sympathetic stimulation of peripheral vessels, a decrease in the activity of the renin-angiotensin system (of great importance for patients with initial hypersecretion of renin), restoration of sensitivity in response to a decrease in blood pressure (BP) and effects on the central nervous system (CNS). With arterial hypertension, the effect occurs after 2–5 days, a stable effect - after 1–2 months.
The antianginal effect is due to a decrease in myocardial oxygen demand as a result of a decrease in heart rate and contractility, lengthening of diastole, and improvement of myocardial perfusion. By increasing the final diastolic pressure in the left ventricle and increasing the stretching of the muscle fibers of the ventricles, it can increase the need for oxygen, especially in patients with chronic heart failure.
Antiarrhythmic effect is due to the elimination of arrhythmogenic factors (tachycardia, increased activity of the sympathetic nervous system, increased content of cAMP, arterial hypertension), a decrease in the rate of spontaneous excitation of sinus and ectopic pacemakers and a slowdown in atrioventricular (AV) conduction (mainly in the antegrade and, to a lesser extent, in the retrograde directions through the AV node) and along additional routes.
Indications
Arterial hypertension
Coronary heart disease: prevention of angina attacks.
Contraindications
Hypersensitivity to the components of the drug and other beta-blockers,
Shock (including cardiogenic)
Collapse
Pulmonary edema
Acute heart failure, chronic heart failure in stage II stage II, stage II decompensation. , sinus node weakness syndrome, severe bradycardia, Prinzmetal angina, cardiomegaly (without signs of heart failure), arterial hypotension (systolic blood pressure less than 100 mm Hg, especially with myocardial infarction)
Bronchial asthma and chronic obstructive pulmonary disease history of srdlk monoamine oxidase inhibitors (MAO) (except MAO-B)
Late stages of peripheral circulatory disorders, Raynaud's disease)
Pheochromocytoma (without the simultaneous use of alpha-adrenoblock tori)
Metabolic acidosis
Age 18 years (effectiveness and safety have been established).
Precautions:
liver failure, chronic renal failure
Myasthenia
Thyrotoxicosis
Diabetes mellitus
Atrioventricular block I degree
Depression (including history)
Psoriasis
Elderly.
Use in pregnancy and lactation
Not described.
Special instructions
Monitoring of patients taking Aritel should include measurement of heart rate and blood pressure (daily at the beginning of treatment, then once every 3-4 months), ECG, determination of blood glucose in patients with diabetes mellitus (1 time in 4-5 months). In elderly patients, it is recommended to monitor renal function (1 time in 4-5 months).
Before starting treatment, it is recommended to study the function of external respiration in patients with a history of bronchopulmonary burden.
With the simultaneous administration of clonidine, its administration can be stopped only a few days after the cancellation of Aritel.
Composition
1 tablet contains:
Active substances:
bisoprolol fumarate 10 mg.
Excipients:
Potato starch
Povidone (kollidon-30)
Lactose
Microcrystalline cellulose
Silicon dioxide colloidal
Magnesium steak suldryl oxide
Dosage and Administration
Aritel inside, in the morning on an empty stomach, without chewing, 5 mg once. If necessary, increase the dose to 10 mg once a day. The maximum daily dose is 20 mg / day.
In patients with impaired renal function with creatine clearance less than 20 ml / min or with severe impaired liver function, the maximum daily dose is 10 mg.
Side effects of
From the central nervous system: increased fatigue, weakness, dizziness, headache, sleep disorders, depression, anxiety, confusion or short-term memory loss, hallucinations, asthenia, myasthenia gravis, paresthesia in the limbs (in patients with intermittent "Lameness and Raynaud's syndrome), tremor.
On the part of the sensory organs: impaired vision, decreased secretion of lacrimal fluid, dry and sore eyes, conjunctivitis.
From the cardiovascular system: sinus bradycardia, palpitations, impaired myocardial conduction, AV block (up to the development of complete transverse blockade and cardiac arrest), arrhythmias, weakening myocardial contractility, development (aggravation) of chronic heart failure (swelling of the ankles, feet shortness of breath), decreased blood pressure, orthostatic hypotension, the manifestation of angiospasm (increased disturbance of peripheral circulation, cooling of the lower extremities, Raynaud's syndrome), chest pain.
From the digestive system: dry oral mucosa, nausea, vomiting, abdominal pain, constipation or diarrhea, impaired liver function (dark urine, yellowness of the sclera or skin, cholestasis), taste changes.
From the respiratory system: nasal congestion, difficulty breathing when prescribed in high doses (loss of selectivity) and / or in predisposed patients - laryngo- and bronchospasm.
From the endocrine system: hyperglycemia (in patients with non-insulin-dependent diabetes mellitus), hypoglycemia (in patients receiving insulin), hypothyroid state.
Allergic reactions: pruritus, rash, urticaria.
From the skin: increased sweating, flushing of the skin, exanthema, psoriasis-like skin reactions, exacerbation of symptoms of psoriasis.
Laboratory indicators: thrombocytopenia (unusual bleeding and hemorrhage), agranulocytosis, leukopenia, changes in liver enzyme activity (increased ALT, AST), bilirubin levels, triglycerides.
Effect on the fetus: intrauterine growth retardation, hypoglycemia, bradycardia.
Other: back pain, arthralgia, decreased libido, decreased potency, withdrawal syndrome (increased angina attacks, increased blood pressure).
Drug Interactions
Allergens used for immunotherapy, or allergen extracts for skin tests increase the risk of severe systemic allergic reactions or anaphylaxis in patients receiving bisoprolol.
Iodine-containing radiopaque drugs for intravenous administration increase the risk of anaphylactic reactions.
Phenytoin when administered intravenously, drugs for inhalation general anesthesia (hydrocarbon derivatives) increase the severity of cardiodepressive action and the likelihood of lowering blood pressure.
Aritel alters the effectiveness of insulin and oral hypoglycemic drugs, masks the symptoms of developing hypoglycemia (tachycardia, increased blood pressure). It reduces the clearance of lidocaine and xanthines (except diphillin) and increases their plasma concentration, especially in patients with initially increased theophylline clearance under the influence of smoking.
Non-steroidal anti-inflammatory drugs (delay of Na + and blockade of prostaglandin synthesis by the kidneys) weaken the antihypertensive effect, glucocorticosteroids and estrogens (delay of Na + ions).
Cardiac glycosides, methyldopa, reserpine and guanfacine, “slow” calcium channel blockers (verapamil, diltiazem), amiodoron and other antiarrhythmic drugs increase the risk of developing or worsening bradycardia, AV blockade, heart failure and heart failure.
Nifedipine can lead to a significant decrease in blood pressure.
Diuretics, clonidine, sympatholytics, hydralazine and other antihypertensive drugs can lead to an excessive decrease in blood pressure.
Extends the effect of non-depolarizing muscle relaxants and the anticoagulant effect of coumarins.
Three - and tetracyclic antidepressants, antipsychotic drugs (antipsychotics), ethanol, sedative and hypnotic drugs increase CNS depression.
The simultaneous use with MAO inhibitors is not recommended due to a significant increase in the antihypertensive effect, the break in treatment between taking MAO inhibitors and bisoprolol should be at least 14 days.
Non-hydrogenated ergot alkaloids increase the risk of peripheral circulation disorders.
Ergotamine increases the risk of developing peripheral circulatory disorders sulfasalazine increases the plasma concentration of bisoprolol rifampicin shortens the elimination half-life.
overdose
Symptoms: arrhythmia, ventricular extrasystole, severe bradycardia, AV blockade, severe BP, chronic heart failure , Cyanosis or nail Paltsev palm, zatrudnenye breathing, bronchospasm, dizziness, obmorochn e STATUS, convulsions.
Treatment: gastric lavage and administration of adsorbing drugs symptomatic therapy: with developed AV blockade - intravenous (I / O) 1-2 mg atropine, epinephrine or staging of a temporary pacemaker for ventricular extrasystole - lidocaine (class Ia drugs are not used) in reducing blood pressure - the patient should be in Trendelenburg if there are no signs of pulmonary edema, - intravenous plasma replacement solutions, inefficiency, inefficiency, of chronotropic and inotropic action and elimination of pronounced decrease in blood pressure) in heart failure - cardiac glycosides, diuretics, glucagon in convulsions - intravenous di yawning with bronchospasm - beta2 - adrenostimulants inhalation.
Storage conditions
In a dry, dark place at a temperature not exceeding 25 РC, out of the reach of children.
active substance
bisoprolol
lekarstvennaja form
tablets
Prescribing
For prescribing
for prescribing
for 5 dfp178frd8pf8 adults prescribed by a doctor
Indications
Indications
hypertension, arrhythmia, heart failure
Canonfarma, Russia p19ff6868fonfarmaf7 . Russia
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