Butadion ointment 5%, 20 g Ozone

• Post-traumatic inflammation of soft tissues and joints, for example, as a result of sprains, strains and bruises.

• Rheumatic diseases of soft tissues (tendovaginitis, bursitis, damage to the periarticular tissues).

• Muscle pains of rheumatic and non-rheumatic origin.

• Pain syndrome and swelling associated with diseases of muscles and joints.

• Rheumatoid arthritis, osteoarthritis, sciatica, lumbago, sciatica.

Outwardly.
Adults and children over 14 years of age: the drug is applied in a thin layer, a strip of 2-3 cm above the focus of inflammation without rubbing 2-3 times a day. The course of treatment is 7-10 days. After 10 days of use, you must consult a doctor.
Elderly patients: no need for a special regimen.

100 g of ointment contains:

Active substance: phenylbutazone - 5.0 g.

• Hypersensitivity to phenylbutazone or other components of the drug, to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (NSAIDs);

• anamnestic data about an attack of bronchial obstruction, allergic rhinitis, urticaria after taking acetylsalicylic acid or other NSAIDs;

• pregnancy (I and III trimester),

• lactation period;

• violation of the integrity of the skin at the site of the intended application;

• children up to age 14;

• joint use with other drugs containing phenylbutazone.

Pharmacological properties
Pharmacodynamics
Nonsteroidal anti-inflammatory drug, has anti-inflammatory and analgesic effect. Indiscriminately inhibits the activity of cyclooxygenase (COX-1 and COX-2) and inhibits the synthesis of prostaglandins.
Phenylbutazone inhibits the synthesis of ATP-dependent mucopolysaccharides.
Butadione is used to relieve pain and reduce swelling associated with the inflammatory process. When applied topically, it causes relief or disappearance of joint pain at rest and during movement. Reduces morning stiffness and swelling of the joints, increases range of motion.
Pharmacokinetics
When applied, systemic absorption is no more than 5%.
Phenylbutazone is metabolized in the liver, excreted in the form of metabolites mainly by the kidneys and about 1/4 through the intestines. The elimination time from blood plasma is long (an average of 70 hours, in the elderly up to 105 hours).

Pregnancy and lactation
The drug is contraindicated in the I and III trimester of pregnancy due to the possibility of fetal development disorders. In the II trimester of pregnancy, Butadion is used only if the intended benefit to the mother outweighs the potential risk to the fetus. If necessary, the use of the drug during lactation is recommended to stop breastfeeding.

Side effects
Local reactions: eczema, photosensitivity, contact dermatitis (itching, redness, swelling of the treated skin area; papules, vesicles, peeling).
Allergic reactions: urticaria, angioedema, bronchospasm, generalized skin rash.

Overdose
Extremely low absorption of the active components of the drug when applied externally makes an overdose almost impossible.
In case of accidental ingestion of large amounts of ointment (more than 20 g), systemic adverse reactions characteristic of NSAIDs may occur. It is necessary to wash the stomach, take activated charcoal.

Interaction with other medicinal products
Clinically significant interactions with other medicinal products have not been described.
Joint use of Butadion with other non-steroidal anti-inflammatory drugs should be avoided.
The drug can enhance the effect of drugs that cause photosensitization.

Special instructions
When redness of the skin appears, therapy should be discontinued.
The ointment should only be applied to intact skin, avoiding contact with open wounds. No occlusive dressing should be applied after application.
Do not allow the drug to come into contact with the eyes and mucous membranes.
The drug should not be used to treat deep vein thrombophlebitis of the extremities. Protect your skin from direct sunlight to prevent photosensitivity. When used together with Yin dosage forms of Butadion, the maximum daily dose of this medicinal product should be taken into account.

Influence on the ability to drive a car and engage in other activities that require concentration of attention and speed of psychomotor reactions
There is no information on the effect of Butadion on the ability to drive and engage in other activities that require concentration of attention and speed of psychomotor reactions.