calcium dobezylat | Doxy-Hem capsules 500 mg 30 pcs.
Special Price
$19.60
Regular Price
$27.00
In stock
SKU
BID462680
Latin name
Doxi-Chem
Doxi-Chem
Latin name
Doxi-Chem
Release form
Capsules 500 mg. 10 capsules per blister of PVC / AL. 3 blisters with instructions for use in a cardboard pack.
Packing
30 pcs
Pharmacological action of
Pharmacodynamics of
Angioprotector, reduces increased vascular permeability, increases the resistance of capillary walls, improves microcirculation and drainage function of lymphatic vessels, moderately reduces platelet aggregation and blood viscosity, increases membrane elasticity. The action is associated to a certain extent with an increase in the activity of plasma kinins.
Pharmacokinetics
Rapidly absorbed in the gastrointestinal tract. The maximum concentration in blood plasma is reached 6 hours after ingestion. Binding to plasma proteins is 20-25%. Almost does not penetrate the blood-brain barrier.
It is excreted by the kidneys (about 50%) and through the intestines (about 50%) mainly in unchanged form for 24 hours, 10% - in the form of metabolites. The half-life is 5 hours.
In very small quantities (0.4 μg / ml after taking 1.5 g of the drug), excreted in breast milk.
Indications
Vascular lesions with increased fragility and permeability of capillaries (diabetic retinopathy and nephropathy) and other microangiopathies associated with various cardiovascular and metabolic diseases.
Venous insufficiency of varying severity and its consequences (pre-varicose veins with swelling of the tissues, pain, paresthesias, congestive dermatosis, superficial phlebitis, varicose veins, trophic ulcers).
Contraindications
Hypersensitivity to calcium dobesilate or any component of the drug, peptic ulcer of the stomach and 12 duodenal ulcer (in the acute stage), bleeding from the digestive tract, kidney and liver diseases, hemorrhages caused by anticoagulants pregnancy (I trimester), children's age (up to 13 years).
Use during pregnancy and lactation
Contraindicated in the first trimester of pregnancy.
Composition
1 capsule contains the active substance: calcium dobesilate (in the form of calcium dobesilate monohydrate 521, 51 mg) - 500.00 mg
excipients: corn starch - 25.164 mg, magnesium stearate - 8.326 mg
Capsule No. 0: case: titanium dioxide E171 - 0.8640 mg, iron dye yellow oxide E172-0.1440 mg
cap: iron dye black oxide E 172 - 0.1920 mg, indigo carmine E132 - 0.1728 mg, titanium dioxide E171 - 0.4800 mg, yellow iron dye oxide E172 - 0.5760 mg, gelatin up to 96 mg.
Dosage and administration
Inside, without chewing, with food.
Assign 500 mg 3 times a day for 2-3 weeks, then reduce the dose to 500 mg once a day. In the treatment of retinopathy and microangiopathy, 500 mg is prescribed 3 times a day for 4-6 months, then the daily dose is reduced to 500 mg 1 time per day.
The course of treatment is from 3-4 weeks to several months, depending on the therapeutic effect.
Side effects
Classification of adverse reactions according to the frequency of development: often - 1-10%, infrequently - 0.1-1%, rarely - 0.01-0.1%, very rarely, including some cases - <0.01 %
Disorders of the gastrointestinal tract. Rarely: nausea, diarrhea, vomiting.
Disorders of the skin and subcutaneous tissue. Rarely: allergic reactions (itching, rash).
General Disorders. Rarely: fever, chills.
Disorders of the musculoskeletal and connective tissue. Rarely: arthralgia.
Disorders of the blood and lymphatic system. In some cases: agranulocytosis. The reaction is reversible and disappears after discontinuation of therapy.
No drug interaction
No data available.
Overdose
No data available.
Storage conditions
At a temperature not exceeding 25 РC in consumer packaging.
Keep out of the reach of children.
Expiration
5 Chron
Deystvuyuschee substances
calcium dobezylat
Pharmacy terms
Prescription
dosage form
dosage form
capsules
Doxi-Chem
Release form
Capsules 500 mg. 10 capsules per blister of PVC / AL. 3 blisters with instructions for use in a cardboard pack.
Packing
30 pcs
Pharmacological action of
Pharmacodynamics of
Angioprotector, reduces increased vascular permeability, increases the resistance of capillary walls, improves microcirculation and drainage function of lymphatic vessels, moderately reduces platelet aggregation and blood viscosity, increases membrane elasticity. The action is associated to a certain extent with an increase in the activity of plasma kinins.
Pharmacokinetics
Rapidly absorbed in the gastrointestinal tract. The maximum concentration in blood plasma is reached 6 hours after ingestion. Binding to plasma proteins is 20-25%. Almost does not penetrate the blood-brain barrier.
It is excreted by the kidneys (about 50%) and through the intestines (about 50%) mainly in unchanged form for 24 hours, 10% - in the form of metabolites. The half-life is 5 hours.
In very small quantities (0.4 μg / ml after taking 1.5 g of the drug), excreted in breast milk.
Indications
Vascular lesions with increased fragility and permeability of capillaries (diabetic retinopathy and nephropathy) and other microangiopathies associated with various cardiovascular and metabolic diseases.
Venous insufficiency of varying severity and its consequences (pre-varicose veins with swelling of the tissues, pain, paresthesias, congestive dermatosis, superficial phlebitis, varicose veins, trophic ulcers).
Contraindications
Hypersensitivity to calcium dobesilate or any component of the drug, peptic ulcer of the stomach and 12 duodenal ulcer (in the acute stage), bleeding from the digestive tract, kidney and liver diseases, hemorrhages caused by anticoagulants pregnancy (I trimester), children's age (up to 13 years).
Use during pregnancy and lactation
Contraindicated in the first trimester of pregnancy.
Composition
1 capsule contains the active substance: calcium dobesilate (in the form of calcium dobesilate monohydrate 521, 51 mg) - 500.00 mg
excipients: corn starch - 25.164 mg, magnesium stearate - 8.326 mg
Capsule No. 0: case: titanium dioxide E171 - 0.8640 mg, iron dye yellow oxide E172-0.1440 mg
cap: iron dye black oxide E 172 - 0.1920 mg, indigo carmine E132 - 0.1728 mg, titanium dioxide E171 - 0.4800 mg, yellow iron dye oxide E172 - 0.5760 mg, gelatin up to 96 mg.
Dosage and administration
Inside, without chewing, with food.
Assign 500 mg 3 times a day for 2-3 weeks, then reduce the dose to 500 mg once a day. In the treatment of retinopathy and microangiopathy, 500 mg is prescribed 3 times a day for 4-6 months, then the daily dose is reduced to 500 mg 1 time per day.
The course of treatment is from 3-4 weeks to several months, depending on the therapeutic effect.
Side effects
Classification of adverse reactions according to the frequency of development: often - 1-10%, infrequently - 0.1-1%, rarely - 0.01-0.1%, very rarely, including some cases - <0.01 %
Disorders of the gastrointestinal tract. Rarely: nausea, diarrhea, vomiting.
Disorders of the skin and subcutaneous tissue. Rarely: allergic reactions (itching, rash).
General Disorders. Rarely: fever, chills.
Disorders of the musculoskeletal and connective tissue. Rarely: arthralgia.
Disorders of the blood and lymphatic system. In some cases: agranulocytosis. The reaction is reversible and disappears after discontinuation of therapy.
No drug interaction
No data available.
Overdose
No data available.
Storage conditions
At a temperature not exceeding 25 РC in consumer packaging.
Keep out of the reach of children.
Expiration
5 Chron
Deystvuyuschee substances
calcium dobezylat
Pharmacy terms
Prescription
dosage form
dosage form
capsules
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