Cyanocobalam | Cyanocobalamin ampoules 500 mcg, 1 ml, 10 pcs.

Release form

Injection.

Packing

In a package of 10 ampoules.

Pharmacological action

Vitamin B12, belongs to the group of water-soluble vitamins. It has a high biological activity. It is necessary for normal hematopoiesis (promotes the maturation of red blood cells). Participates in the processes of transmethylation, hydrogen transfer, the formation of methionine, nucleic acids, choline, creatine. Promotes the accumulation of compounds containing sulfhydryl groups in red blood cells. It has a beneficial effect on the function of the liver and nervous system. It participates in the synthesis of the myelin sheath, stimulates hematopoiesis, reduces pain associated with damage to the peripheral nervous system, and stimulates nucleic acid metabolism via folic acid activation. It activates the blood coagulation system, in high doses causes an increase in the activity of thromboplastin and prothrombin.

Indications

Anemia due to B12 deficiency

as part of combination therapy for iron deficiency and posthemorrhagic anemia

aplastic anemia caused by toxic substances and drugs

liver disease (hepatitis, cirrhosis)

funicular myelosis

polyneuritis

radiculitis

neuralgia

amyotrophic lateral sclerosis

cerebral palsy

Down syndrome

dermatitis, dermatitis and dermatitis (dermatitis, psoriasis, dermatitis, dermatitis including when using biguanides, PASK, vitamin C in high doses)

radiation sickness.

Contraindications

Thromboembolism,

erythremia,

erythrocytosis,

hypersensitivity to cyanocobalamin.

Use during pregnancy and lactation

There is some evidence of a possible teratogenic effect on the fetus of large doses of B vitamins, and therefore should not be used cyanocobalamin during pregnancy.

Special instructions

For angina pectoris, a single dose of not more than 100 mcg should be used.

Composition

1 ampoule contains: cyanocobalamin - 500 mcg.

Excipients: sodium chloride, water for injection.

Dosage and administration

Injected sc, i / m, iv and intralumbal, as well as inside.

For anemia associated with vitamin B12 deficiency, 100-200 mcg is administered every other day. With anemia with the phenomena of funicular myelosis and with macrocytic anemia with diseases of the nervous system - 400-500 mcg in the first 7 days daily, then 1 time in 5-7 days. In the period of remission, in the absence of the phenomena of funicular myelosis, the maintenance dose is 100 mcg 2 times a month, in the presence of neurological symptoms, 200-400 mcg 2-4 times a month.

In acute posthemorrhagic and iron deficiency anemia - 30-100 mcg 2-3 times a week. With aplastic anemia (especially in children) - 100 mcg before the onset of clinical improvement. With alimentary anemia in young children and premature babies - 30 mcg / day for 15 days.

For diseases of the central and peripheral nervous system, neurological diseases with pain are administered in increasing doses - 200-500 mcg, with improvement - 100 mcg / day. The course of treatment is 2 weeks. In case of traumatic lesions of the peripheral nervous system - 200-400 mcg every other day for 40-45 days.

With hepatitis and cirrhosis of the liver - 30-60 mcg / day or 100 mcg every other day for 25-40 days.

With dystrophies in young children, Down's disease and cerebral palsy - 15-30 mcg every other day.

In case of funicular myelosis, amyotrophic lateral sclerosis, 15-30 micrograms can be introduced into the spinal canal, gradually increasing the dose to 200-250 micrograms.

In case of radiation sickness, diabetic neuropathy, spru - 60-100 mcg daily for 20-30 days.

In case of vitamin B12 deficiency for prophylaxis - 1m i / m / i / 1 mg once a month for treatment - i / m or i / v 1mg daily for 1-2 weeks, maintenance dose 1-2 mg / m or iv - from 1 time per week to 1 time per month. The duration of treatment is set individually.

Side effects

Stimulation, pain in the heart, tachycardia, allergic reactions.

Drug interaction

Incompatible (in the same syringe) with thiamine bromide, riboflavin.

Storage Conditions

In a light-proof location.

Expiration

2 years.

Terms leave through pharmacies

Prescription

lekarstvennaja form

Solution for

Indications for psoriasis, Otosis, anemia, Pemia, anemia, anemia for liver damage, From radiculitis, Neurodermatitis, From hepatitis, From trigeminal neuralgia, From alcoholism, From Crohn's disease, Dermatitis

Possible product names

cyanocobalamin ampoules 500 mcg, 1 ml, 10 pcs.

Dalkhimpharm, Russia