Cycloferon solution for injection 125mg / ml, 2ml No. 5

As part of complex therapy in adults:

HIV infection (stages 2A-2B);

neuroinfections: serous meningitis and encephalitis, tick-borne borelliosis (Lyme disease);

viral hepatitis A, B, C, D;

herpes infection;

cytomegalovirus infection;

secondary immunodeficiencies associated with acute and chronic bacterial and fungal infections;

chlamydial infections;

diseases of the musculoskeletal system and connective tissue (rheumatoid arthritis, systemic lupus erythematosus, deforming osteoarthritis).

As part of complex therapy in children aged 4 years and older:

viral hepatitis A, B, C, D;

herpes infection;

HIV infection (stages 2A-2B).

For adults, CycloferonЃ is administered intramuscularly or intravenously 1 time / day according to the basic scheme: every other day. The duration of treatment depends on the disease.

For herpes and cytomegalovirus infections, the drug is prescribed according to the basic scheme - 10 injections of 250 mg each. The total dose is 2.5 g. Treatment is most effective at the beginning of an exacerbation of the disease.

For neuroinfections, the drug is administered according to the basic scheme. The course of treatment is 12 injections of 250-500 mg in combination with etiotropic therapy. The total dose is 3-6 g. Repeated courses are carried out as needed.

With chlamydial infection, treatment is carried out according to the basic scheme. The course of treatment is 10 injections of 250 mg each. The total dose is 2.5 g. The course is repeated in 10-14 days.

It is advisable to combine Cycloferon with antibiotics.

In acute viral hepatitis A, B, C, D and mixed forms, the drug is administered according to the basic scheme of 10 injections of 500 mg each. The total dose is 5 g. With a prolonged course, a second course is carried out in 10-14 days.

In chronic viral hepatitis B, C, D and mixed forms, the drug is administered according to the basic scheme of 10 injections of 500 mg each, then according to the maintenance scheme 3 times a week. within 3 months as part of complex therapy. Recommended in combination with interferons and chemotherapy. The repetition of the course is carried out in 10-14 days.

In HIV infection (stage 2A-2B), the drug is prescribed according to the basic scheme of 10 injections of 500 mg each and then according to the maintenance scheme once every three days for 2.5 months. The repetition of the course is carried out after 10 days.

In immunodeficiency states, the course of treatment consists of 10 intramuscular injections according to the basic scheme in a single dose of 250 mg. The total dose is 2.5 g. The second course is carried out in 6-12 months.

With rheumatoid arthritis, systemic lupus erythematosus, 4 courses of 5 injections are prescribed according to the basic scheme, 250 mg each with a break of 10-14 days. The doctor determines the need for a second course individually.

With deforming osteoarthritis, 2 courses of 5 injections of 250 mg each are prescribed with a break of 10-14 days according to the basic scheme. The doctor determines the need for a second course individually.

For children, CycloferonЃ is prescribed intramuscularly or intravenously 1 time / day according to the basic scheme: every other day. The daily therapeutic dose is 6-10 mg / kg of body weight.

In acute viral hepatitis A, B, C, D and mixed forms, 15 injections of the drug are carried out according to the basic scheme. With a protracted course of infection, the course is repeated after 10-14 days.

In chronic viral hepatitis B, C, D, the drug is administered according to the basic scheme of 10 injections and then according to the maintenance scheme 3 times a week for 3 months as part of complex therapy. It is recommended to use in combination with interferons and chemotherapy.

In HIV infection (stages 2A-2B), a course of 10 injections is prescribed according to the basic scheme and then according to the maintenance scheme once every 3 days for 3 months. The repeated course is carried out in 10 days.

With herpes infection, a course of 10 injections is carried out according to the basic scheme. While maintaining the replicative activity of the virus, the course of treatment is continued according to the maintenance scheme with the introduction of the drug 1 time in 3 days for 4 weeks.

The solution for i / v and i / m administration is transparent, yellow.

1 ml meglumine acridone acetate * (calculated as acridone acetic acid) 125 mg

* obtained according to the following recipe: acridoneacetic acid - 125 mg, meglumine (N-methylglucamine) - 96.3 mg.

Excipients: water d / i - up to 1 ml.

• Liver cirrhosis in the stage of decompensation;

• children under 4 years of age;

• pregnancy;

• lactation period (breastfeeding);

• hypersensitivity to the components of the drug.

pharmachologic effect

Meglumine acridone acetate is a low-molecular-weight interferon inducer, which determines a wide range of its biological activity (antiviral, immunomodulatory, anti-inflammatory). The main cells-producers of interferon after administration of the drug are macrophages, T- and B-lymphocytes. Depending on the type of infection, there is a predominance of the activity of one or another link of immunity. The drug induces high titers of interferon in organs and tissues containing lymphoid elements (spleen, liver, lungs), activates bone marrow stem cells, stimulating the formation of granulocytes. CycloferonЃ activates T-lymphocytes and natural killer cells, normalizes the balance between subpopulations of T-helpers and T-suppressors. Enhances the activity of? -Interferons. CycloferonЃ is effective against tick-borne encephalitis viruses, influenza,hepatitis, herpes, cytomegalovirus, human immunodeficiency virus, papilloma virus and other viruses. In acute viral hepatitis, CycloferonЃ prevents the transition of diseases to a chronic form. At the stage of primary manifestations of HIV infection, it helps to stabilize immunity indicators. The drug was found to be highly effective in the complex therapy of acute and chronic bacterial infections (neuroinfection, chlamydia, bronchitis, pneumonia, postoperative complications, urogenital infections, peptic ulcer) as a component of immunotherapy. CycloferonЃ is highly effective in rheumatic and systemic diseases of the connective tissue, suppressing autoimmune reactions and providing anti-inflammatory and analgesic effects.papilloma virus and other viruses. In acute viral hepatitis, CycloferonЃ prevents the transition of diseases to a chronic form. At the stage of primary manifestations of HIV infection, it helps to stabilize immunity indicators. The drug was found to be highly effective in the complex therapy of acute and chronic bacterial infections (neuroinfection, chlamydia, bronchitis, pneumonia, postoperative complications, urogenital infections, peptic ulcer) as a component of immunotherapy. CycloferonЃ is highly effective in rheumatic and systemic diseases of the connective tissue, suppressing autoimmune reactions and providing anti-inflammatory and analgesic effects.papilloma virus and other viruses. In acute viral hepatitis, CycloferonЃ prevents the transition of diseases to a chronic form. At the stage of primary manifestations of HIV infection, it helps to stabilize immunity indicators. The drug was found to be highly effective in the complex therapy of acute and chronic bacterial infections (neuroinfection, chlamydia, bronchitis, pneumonia, postoperative complications, urogenital infections, peptic ulcer) as a component of immunotherapy. CycloferonЃ is highly effective in rheumatic and systemic diseases of the connective tissue, suppressing autoimmune reactions and providing anti-inflammatory and analgesic effects.At the stage of primary manifestations of HIV infection, it helps to stabilize immunity indicators. The drug was found to be highly effective in the complex therapy of acute and chronic bacterial infections (neuroinfection, chlamydia, bronchitis, pneumonia, postoperative complications, urogenital infections, peptic ulcer) as a component of immunotherapy. CycloferonЃ is highly effective in rheumatic and systemic diseases of the connective tissue, suppressing autoimmune reactions and providing anti-inflammatory and analgesic effects.At the stage of primary manifestations of HIV infection, it helps to stabilize immunity indicators. The drug was found to be highly effective in the complex therapy of acute and chronic bacterial infections (neuroinfection, chlamydia, bronchitis, pneumonia, postoperative complications, urogenital infections, peptic ulcer) as a component of immunotherapy. CycloferonЃ is highly effective in rheumatic and systemic diseases of the connective tissue, suppressing autoimmune reactions and providing anti-inflammatory and analgesic effects.peptic ulcer) as a component of immunotherapy. CycloferonЃ is highly effective in rheumatic and systemic diseases of the connective tissue, suppressing autoimmune reactions and providing anti-inflammatory and analgesic effects.peptic ulcer) as a component of immunotherapy. CycloferonЃ is highly effective in rheumatic and systemic diseases of the connective tissue, suppressing autoimmune reactions and providing anti-inflammatory and analgesic effects.

Pharmacokinetics

When administered in the maximum permissible dose, Cmax in blood plasma is reached after 1-2 hours. After 24 hours, the active substance is found in trace amounts. Penetrates the BBB. T1 / 2 is 4-5 hours. With prolonged use, cumulation in the body is not observed.

Side effect

Skin and subcutaneous tissue disorders: very rarely - rash, urticaria. General disorders and disorders at the injection site: very rarely - chills, fever, pain and redness at the injection site. If any of the undesirable effects indicated in the instructions are aggravated or any other undesirable effects not specified in the instructions are noted, the patient should be informed about this by the doctor.

Application during pregnancy and lactation

The use of the drug during pregnancy and during breastfeeding is contraindicated.

Application for violations of liver function

Contraindicated in liver cirrhosis in the stage of decompensation.

special instructions

For diseases of the thyroid gland, an endocrinologist must be consulted before using CycloferonЃ. Possible staining of urine in a violet-blue color (luminescence). When the color of the solution changes and a precipitate forms, the use of the drug is unacceptable.

Influence on the ability to drive vehicles and mechanisms

CycloferonЃ does not affect the ability to drive vehicles and mechanisms.

Drug interactions

CycloferonЃ is compatible and well combined with all drugs traditionally used in the treatment of these diseases (including interferons and chemotherapeutic agents). CycloferonЃ enhances the effect of interferons and nucleoside analogs. When used together, CycloferonЃ reduces the side effects of chemotherapy and interferon therapy.