CYSTALIS capsules 350 mg 60 pcs.

CYSTALIS" helps to alleviate symptoms in acute and chronic cystitis.

Prevention of exacerbation of chronic cystitis.

Characteristics of the components of the "CYSTALIS" complex ("CYSTALIS")

Numerous literary medical data * have confirmed the efficacy and safety of the components included in the CYSTALIS complex when used in people with cystitis:

D-Mannose (D-Mannose)

D-mannose is rapidly absorbed and reaches the organs after 30 minutes, after which it is excreted in the urine in a completely unchanged form.

D-mannose is not absorbed by the cells of the body and does not affect carbohydrate metabolism.

The main pharmacological action of D-mannose is to prevent the attachment of the pathogenic E. coli (E. coli) to the cells of the bladder mucosa.

Free-floating forms of E. coli are excreted in the urine.

Clinical studies have shown that D-mannose reduces the likelihood of cystitis recurrence by 4 times within 6 months.

Arbutin (from the extract of Bearberry, Arctostaphylos Uva-UrsiJ

Bearberry is an evergreen shrub of the Heather family also known as Bear's Ear. Bearberry leaves have long been used by people in the treatment of infectious and inflammatory diseases of the urinary system. The main active ingredient in bearberry extract is arbutin. Arbutin and its derivative hydroquinone have a direct cytotoxic effect on bacterial cells. Having a specific effect on the bacterial membrane, arbutin causes its destruction, as well as denaturation of proteins of the internal environment of bacteria. The antimicrobial activity of arbutin is also due to the fact that it increases the solubility of the surface of microbial cells and thereby prevents their adhesion to the cell walls of the urinary tract, and also causes agglutination (sticking) of bacteria to each other.

Bearberry also acts as a diuretic, helping to get rid of urinary tract infections, further preventing bacterial adhesion and colonization.

It was found that the use of arbutin-containing extracts can increase the effectiveness of antibiotics and reduce their toxicity.

Oligomeric Proanthocyanidins (from Grape Seed extract)

Proanthocyanidins are a class of polyphenols discovered in 1947 by Jack Maselier of the University of Bordeaux, France.

Proanthocyanidins are divided into several types: monomeric, oligomeric, polymeric.

It is the oligomeric proanthocyanidins that have antibacterial, anti-inflammatory effects in cystitis. Cranberries are considered to be a traditional source of proanthocyanidins in urological practice. However, the content of oligomeric proanthocyanidins (ORCs) in grape seeds is 1 O times higher than in cranberries. Oligomeric proanthocyanidicins have a pronounced anti-inflammatory effect, reducing the production of hydrogen peroxide molecules by immune cells in the bladder, as well as reducing the level of pro-inflammatory molecules (cytokines). In addition, ORS have antioxidant properties helping to preserve the protective function of the bladder mucosa. Experimental studies have shown that the anti-inflammatory capacity of grape seed proanthocyanidins is comparable to that of hormonal steroid drugs.However, proanthocyanidins have an excellent safety profile.

* Sources of literary medical data:

Michaels EK Urol Res 1983

11: 97-102.

Li WG, Zhang XY, Wu YJ, Tian X. Acta Pharmacol 5in.

2001 Dec: 22 (12): 1117-20.

Kranji'ec B, Papes D, Altarac 5. World J Urol 32 (1): 79-84.

Porru, D., Parmigiani, A., Tinelli, CJournal of Clinical Urology, 7 (3), 208-21 Z.

doi: 1О.1177 / 2051415813518332.

Quintus, J., Kovar, K.A., Link, P.,.

Planta Med.

2005 (71), 147-152.

Garcia de Arriba, 5., 5tammwitz, U., Pickartz,

5., lnt.

J. Drug Dev.

Res.

2010 (3), 85-100.

Geetha, RV, Anitha, R., Lakshmi, T., lnt.

J. Drug Dev.

Res.

2011 (3), 85-100.

EF5AJournal.

12 (5): 3657 (11 pgs).

2014.doi: 10.2903 / j.efsa.2014.3657.

Beecher, GR Archives Of Physiology And Biochemistry, 2004 42 (s1),

2-20.

doi: 1 О.1080 / 13880200490893474.

Howell, AB Mol Nutr Food Res.

51 (6): 732-737.

doi: 10.1002 / mnfr.200700038.

INN / Active ingredient

ARBUTIN

Proanthocyanidines

Dosage

1 capsule contains: Grape seed extract - 52.5 mg, D-mannose - 240 mg, Bearberry extract - 57.5 mg

Structure

- D-Mannose (D-Mannose)

- Herb extract of Bearberry

(Arctostaphylos Uva-Ursi)

- Grape Seed extract

A daily dose (2 capsules) contains at least:

Arbutin - 10 mg

Proanthocyanidins - 90 mg

Contraindications

Individual intolerance to the components of the product, pregnancy, breastfeeding.

Specifications

Category

Inflammation and infections

Release form

Capsules

Manufacturer country

Russia

Package quantity, pcs

60

Scope of the drug

Genitourinary system

Minimum age from

18 years

For children

No

Dosage (volume) of the substance in the preparation

350 mg

Scope of application

Urology

Contraindications dietary supplements

Dietary supplement.

NOT A DRUG

Expiration date in days

730

A type

Dietary supplement

Package weight, g

fifty

Mode of application

:

Adults take 1 capsule 2 times a day with meals.

Duration of admission: 1 month.

If necessary, the reception can be repeated.

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