Diacarb tablets 250mg, 30

- edematous syndrome (mild to moderate severity, in combination with alkalosis);
- glaucoma (primary and secondary, as well as in an acute attack);
- epilepsy (as part of combination therapy);
- intracranial hypertension;
- acute altitude (mountain) sickness (the drug shortens the acclimatization time, but its effect on the symptoms of the disease is insignificant).

In case of edematous syndrome at the beginning of treatment, the drug is prescribed in a dose of 250-375 mg (1-1.5 tab.) 1 time / day in the morning. The maximum diuretic effect is achieved when the drug is taken every other day or 2 days in a row, and then a one-day break. When using Diakarb, therapy for circulatory failure, including cardiac glycosides, should be continued, a diet with limited salt intake and potassium deficiency should be replenished.

For adults with open-angle glaucoma, the drug is prescribed in a single dose of 250 mg (1 tab.) 1-4 times / day. Doses exceeding 1 g do not increase the therapeutic effect. In secondary glaucoma, the drug is prescribed in a single dose of 250 mg (1 tab.) Every 4 hours. In some patients, the therapeutic effect is manifested after a short-term intake of the drug at 250 mg 2 times / day. In acute attacks of glaucoma, the drug is prescribed at 250 mg 4 times / day.

For children with attacks of glaucoma, Diacarb is prescribed at a dose of 10-15 mg / kg of body weight per day for 3-4 doses.

For epilepsy, adults are prescribed 250-500 mg / day in one dose for 3 days, on the 4th day - a break. Children aged 4 to 12 months 50 mg / day in 1-2 doses; 2-3 years - 50-125 mg / day in 1-2 doses; 4-18 years old, 125-250 mg 1 time / day in the morning. With the simultaneous use of Diakarb with other anticonvulsants at the beginning of treatment, 250 mg (1 tab.) 1 time / day is used, if necessary, gradually increasing the dose. Doses in excess of 750 mg / day should not be used in children.

For mountain sickness, it is recommended to use the drug in a dose of 500-1000 mg (2-4 tablets) per day; in the case of a rapid ascent - 1000 mg / day. The daily dose is divided into several doses in equal doses. The drug should be used 24-48 hours before the ascent, and if symptoms of the disease appear, continue treatment for the next 48 hours or more, if necessary.

If you skip taking the drug, you should not increase the dose with the next dose.

Active substance:

acetazolamide (acetazolamide) 250 mg

Excipients: potato starch, talc, sodium starch glycolate.

- acute renal failure;
- liver failure;
- cirrhosis of the liver;
- hypokalemia;
- acidosis;
- hypocorticism;
- Addison's disease;
- uremia;
- diabetes;
- pregnancy;
- lactation;
- hypersensitivity to the components of the drug.

Ingredients: 1 tab.

Active substance:

acetazolamide (acetazolamide) 250 mg

Excipients: potato starch, talc, sodium starch glycolate.

Clinical and pharmacological group: Diuretic. Carbonic anhydrase inhibitor

pharmachologic effect

A diuretic from the group of carbonic anhydrase inhibitors. It has a weak diuretic effect. Inhibits the enzyme carbonic anhydrase in the proximal convoluted tubule of the nephron, increases urinary excretion of sodium, potassium, bicarbonate ions, does not affect the excretion of chlorine ions; causes an increase in urine pH. Violates the acid-base balance (metabolic acidosis). Inhibition of carbonic anhydrase of the ciliary body leads to a decrease in the secretion of aqueous humor and a decrease in intraocular pressure. Suppression of the activity of carbonic anhydrase in the brain determines the anticonvulsant activity of the drug.

The use of the drug with increased intracranial pressure is associated with the suppression of carbonic anhydrase in the plexus of the ventricles of the brain and a decrease in the production of cerebrospinal fluid.

Duration of action - up to 12 hours.

Pharmacokinetics

Suction

After oral administration, acetazolamide is well absorbed from the gastrointestinal tract. After taking Diakarb at a dose of 500 mg, the Cmax of the active substance is 12-27 ?g / ml and is achieved after 1-3 hours. The determined concentration of acetazolamide in plasma is maintained for 24 hours after taking the drug.

Distribution and metabolism

It is distributed mainly in erythrocytes, kidneys, muscles, tissues of the eyeball and the central nervous system. Binds to plasma proteins to a high degree. Penetrates the placental barrier. Acetazolamide is not biotransformed in the body.

Withdrawal

It is excreted by the kidneys unchanged. About 90% of the dose is excreted in the urine within 24 hours.

Indications
- edematous syndrome (mild to moderate severity, in combination with alkalosis);
- glaucoma (primary and secondary, as well as in an acute attack);
- epilepsy (as part of combination therapy);
- intracranial hypertension;
- acute altitude (mountain) sickness (the drug shortens the acclimatization time, but its effect on the symptoms of the disease is insignificant).

Method of administration and dosage

In case of edematous syndrome at the beginning of treatment, the drug is prescribed in a dose of 250-375 mg (1-1.5 tab.) 1 time / day in the morning. The maximum diuretic effect is achieved when the drug is taken every other day or 2 days in a row, and then a one-day break. When using Diakarb, therapy for circulatory failure, including cardiac glycosides, should be continued, a diet with limited salt intake and potassium deficiency should be replenished.

For adults with open-angle glaucoma, the drug is prescribed in a single dose of 250 mg (1 tab.) 1-4 times / day. Doses exceeding 1 g do not increase the therapeutic effect. In secondary glaucoma, the drug is prescribed in a single dose of 250 mg (1 tab.) Every 4 hours. In some patients, the therapeutic effect is manifested after a short-term intake of the drug at 250 mg 2 times / day. In acute attacks of glaucoma, the drug is prescribed at 250 mg 4 times / day.

For children with attacks of glaucoma, Diacarb is prescribed at a dose of 10-15 mg / kg of body weight per day for 3-4 doses.

For epilepsy, adults are prescribed 250-500 mg / day in one dose for 3 days, on the 4th day - a break. Children aged 4 to 12 months 50 mg / day in 1-2 doses; 2-3 years - 50-125 mg / day in 1-2 doses; 4-18 years old, 125-250 mg 1 time / day in the morning. With the simultaneous use of Diakarb with other anticonvulsants at the beginning of treatment, 250 mg (1 tab.) 1 time / day is used, if necessary, gradually increasing the dose. Doses in excess of 750 mg / day should not be used in children.

For mountain sickness, it is recommended to use the drug in a dose of 500-1000 mg (2-4 tablets) per day; in the case of a rapid ascent - 1000 mg / day. The daily dose is divided into several doses in equal doses. The drug should be used 24-48 hours before the ascent, and if symptoms of the disease appear, continue treatment for the next 48 hours or more, if necessary.

If you skip taking the drug, you should not increase the dose with the next dose.

Side effect
From the side of the central nervous system and peripheral nervous system: convulsions, paresthesia, anorexia, tinnitus, myopia; with prolonged use - disorientation, impaired touch, drowsiness.
From the side of the hematopoietic system: in some cases with prolonged use - hemolytic anemia, leukopenia, agranulocytosis.
On the part of water-electrolyte balance and acid-base balance: hypokalemia, metabolic acidosis.
From the urinary system: in some cases with prolonged use - nephrolithiasis, transient hematuria and glucosuria.
From the digestive system: anorexia; with prolonged use - nausea, vomiting, diarrhea.
Dermatological reactions:rarely - redness of the skin, itching.
Others: rarely - muscle weakness, allergic reactions.

Contraindications
- acute renal failure;
- liver failure;
- cirrhosis of the liver;
- hypokalemia;
- acidosis;
- hypocorticism;
- Addison's disease;
- uremia;
- diabetes;
- pregnancy;
- lactation;
- hypersensitivity to the components of the drug.

Pregnancy and lactation

Diacarb is contraindicated for use during pregnancy and lactation.

special instructions

The drug is prescribed with caution for edema of hepatic and renal genesis and when taken together with acetylsalicylic acid.
When the drug is prescribed for more than 5 days in a row, the risk of developing metabolic acidosis increases.
The drug should be used with caution in elderly patients and / or patients with impaired renal function due to an increased risk of metabolic acidosis.

Control of laboratory parameters

With prolonged use of the drug, the peripheral blood picture, indicators of water-electrolyte balance and acid-base metabolism should be monitored.

Overdose
Symptoms: the described side effects may increase.
Treatment: symptomatic therapy is performed.

Drug Interactions
When used together with antiepileptic drugs, Diacarb enhances the manifestations of osteomalacia.
With the combined use of Diakarb with other diuretics and theophylline, the diuretic effect is enhanced.
With the simultaneous use of Diakarb with acid-forming diuretics, the diuretic effect decreases.
With the simultaneous use of Diakarb increases the risk of toxic effects of salicylates, digitalis drugs, carbamazepine, ephedrine, non-depolarizing muscle relaxants.

Terms and conditions of storage
The drug should be stored in a dry, dark place and out of reach of children at a temperature not exceeding 25 ? C.

The shelf life is 5 years.

Conditions of dispensing from pharmacies
The drug is dispensed by prescription.