Dicycloverine, Paracetamol | Trigan-D tablets, 20 pcs.

Packaging

20 pcs

Pharmacological action

Pharmacological action - antispasmodic, analgesic.

Paracetamol, which is part of the preparation, has analgesic, antipyretic and insignificant anti-inflammatory effects.

The mechanism of action is associated with moderate inhibition of cyclooxygenase-1 and, to a lesser extent, cyclooxygenase-2 in peripheral tissues and the central nervous system, which results in inhibition of the biosynthesis of prostaglandins of modulators of pain sensitivity, thermoregulation and inflammation.

The second component of dicycloverin hydrochloride is a tertiary amine, which has a relatively weak non-selective m-anticholinergic and direct myotropic antispasmodic effect on the smooth muscles of internal organs.

In therapeutic doses, it causes effective relaxation of smooth muscles, which is not accompanied by side effects characteristic of atropine.

The combined action of the two components of Trigan-D provides relaxation of the spasmodic smooth muscles of the internal organs and the weakening of pain.

Indications

Spasm of smooth muscle of internal organs.

Intestinal colic.

Hepatic colic.

Renal colic.

Algodismenorea.

Headache.

Toothache.

Migraine pain.

Neuralgia.

myalgia.

Infectious and inflammatory diseases accompanied by fever.

Use during pregnancy and lactation

Contraindicated in pregnancy and lactation.

Composition

1 tablet contains dicycloverin hydrochloride 20 mg, paracetamol 500 mg

Dosage and administration

Applied orally.

Adults and children over 15 years of age: 1 tablet 2-3 times a day.

The maximum single dose for adults is - 2 tablets, daily 4 tablets.

Duration of admission without consulting a doctor is not more than 5 days when prescribed as an anesthetic and 3 days as an antipyretic.

With prolonged use of the drug, it is necessary to control the picture of peripheral blood and the functional state of the liver.

Do not exceed the daily dose: its increase or a longer treatment is possible only under medical supervision, as an overdose of the drug can cause liver failure.

Side effects

From the gastrointestinal tract

Dry mouth, loss of taste, loss of appetite, epigastric pain, constipation, increased activity of liver enzymes, usually without the development of jaundice, hepatonecrosis (dose-dependent effect).

Allergic reactions

Skin rash, itching, urticaria, Quincke's edema, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome).

With the central nervous system (usually develops when taking high doses)

Drowsiness, Dizziness, psychomotor agitation and disorientation.

From the endocrine system

Hypoglycemia, up to hypoglycemic coma.

Hematopoietic organs

Anemia, methemoglobinemia (cyanosis, shortness of breath, heart pain), hemolytic anemia (especially for patients with gluco-6-phosphate dehydrogenase deficiency).

From the genitourinary system

Piuria, urinary retention, interstitial nephritis, papillary necrosis.

From the side of the organs of vision

Mydriasis blurred visual perception, paralysis of accommodation, increased intraocular pressure.

On the part of the reproductive system

Decreased potency.

Drug Interaction

The effect is enhanced by amantadine, an antipsychotic agent, benzodiazepines, MAO inhibitors, narcotic analgesics, nitrates and nitrites, sympathomimetics, tricyclic antidepressants, cholinolytics, corticosteroids reduce - antacids.

Increases the effects of digoxin.

Overdose

Symptoms: tachycardia, tachypnoea, fever, arousal, convulsions, epigastric pain, decreased appetite, anemia, thrombocytopenia, hemolytic anemia, aplastic anemia, methemoglobitinemia, methemoglobrocinemia, methemoglobrocinemia

Treatment: stop taking the drug, do gastric lavage, appoint adsorbents, introduce agents that increase the formation of glutathione (acetylcysteine ​​intravenously) and enhance conjugation reactions (methionine inside).

Storage conditions

In a dry, dark place at a temperature not exceeding 25 РC

The Expiration of

is 3 years.

Active ingredient

Paracetamol



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Dosage form

dosage form

tablets