Dimexide gel 25% 30g tube

• to relieve pain in the complex therapy of rheumatoid arthritis, ankylosing spondylitis, deforming osteoarthritis, arthropathy, radiculitis, trigeminal neuralgia;

• for the treatment of bruises, ligament damage, traumatic infiltrates;

• in the treatment of erythema nodosum.

Apply externally.

For adults and children over 12 years of age, the drug is applied with a thin layer to the affected area 1-2 times / day. Duration of treatment is 10-14 days. Repeated courses can be carried out at least 10 days later.

Active ingredient: dimethyl sulfoxide - 25 g

Excipients: methyl parahydroxybenzoate (nipagin) - 0.05 g, propyl parahydroxybenzoate (nipazole) - 0.013 g, sodium carmellose (sodium carboxymethyl cellulose) - 2 g, purified water - up to 100 g.

• severe liver damage;

• severe kidney damage;

• angina pectoris;

• myocardial infarction;

• severe atherosclerosis;

• various types of strokes;

• glaucoma;

• cataract;

• coma;

• children under 12 years of age;

• pregnancy;

• lactation period;

• hypersensitivity to dimethyl sulfoxide or other components of the drug.

With caution , Dimexide should be prescribed simultaneously with other drugs, due to the fact that it can enhance not only the activity, but also the toxicity of some drugs.

Gel for external use 25% colorless or with a yellowish tinge, transparent, with a weak specific odor.

Composition:

Active ingredient: dimethyl sulfoxide - 25 g

Excipients: methyl parahydroxybenzoate (nipagin) - 0.05 g, propyl parahydroxybenzoate (nipazole) - 0.013 g, sodium carmellose (sodium carboxymethyl cellulose) - 2 g, purified water - up to 100 g.

Clinical and pharmacological group: Drug with anti-inflammatory and analgesic action for external use

Pharmaco-therapeutic group: Anti-inflammatory agent for external use

pharmachologic effect

A drug with anti-inflammatory and local analgesic action. It has moderate antiseptic properties and fibrinolytic effect.

Dimethyl sulfoxide inhibits inflammatory tissue infiltration. In addition, dimethyl sulfoxide contributes to the normalization of fibrin formation processes, increases microcirculation in tissues, inhibiting the aggregation of erythrocytes, increases the activity of phagocytes, suppresses chemotaxis of neutrophils and reduces the content of circulating immune complexes.

Penetrates through the skin, mucous membranes, the cell wall of bacteria (increases their sensitivity to antibiotics) and other biological membranes, increases their permeability to drugs. The drug is low-toxic.

Pharmacokinetics

Absorption and distribution

When the drug is applied, dimethyl sulfoxide is detected in the blood serum after 8-15 minutes, and Cmax is noted after 2-8 hours. As a rule, after 30-36 hours, dimethyl sulfoxide is no longer detected in the blood serum.

With external use of the drug, dimethyl sulfoxide penetrates into the articular cavity, binds to proteins in the blood and tissues. Dimethyl sulfoxide does not cumulate.

Metabolism and excretion

Dimethyl sulfoxide is excreted from the body in the urine unchanged and in the form of oxidation products - dimethyl sulfone and dimethyl sulfate, as well as in the form of a reduced product (dimethyl sulfide) is excreted in the exhaled air.

Indications

• to relieve pain in the complex therapy of rheumatoid arthritis, ankylosing spondylitis, deforming osteoarthritis, arthropathy, radiculitis, trigeminal neuralgia;

• for the treatment of bruises, ligament damage, traumatic infiltrates;

• in the treatment of erythema nodosum.

Dosage regimen

Apply externally.

For adults and children over 12 years of age, the drug is applied with a thin layer to the affected area 1-2 times / day. Duration of treatment is 10-14 days. Repeated courses can be carried out at least 10 days later.

Side effect

In the process of using the drug, contact dermatitis, a garlic smell of exhaled air, increased skin pigmentation, allergic reactions, erythematous rashes, dry skin, and a slight burning sensation can be observed.

Some patients perceive the smell of the drug poorly (nausea, retching), in rare cases, bronchospasm is possible.

If any of the side effects indicated in the instructions are aggravated or any other side effects not indicated in the instructions are noted, the patient should inform the doctor about it.

Contraindications for use

• severe liver damage;

• severe kidney damage;

• angina pectoris;

• myocardial infarction;

• severe atherosclerosis;

• various types of strokes;

• glaucoma;

• cataract;

• coma;

• children under 12 years of age;

• pregnancy;

• lactation period;

• hypersensitivity to dimethyl sulfoxide or other components of the drug.

With caution , Dimexide should be prescribed simultaneously with other drugs, due to the fact that it can enhance not only the activity, but also the toxicity of some drugs.

Application during pregnancy and lactation

The use of the drug during pregnancy and lactation is contraindicated.

Application for violations of liver function

Contraindicated in severe liver damage.

Application for impaired renal function

Contraindicated in severe kidney damage.

Application in children

Prescription for children under 12 years of age is contraindicated.

special instructions

Given the possibility of individual intolerance to the drug, it is recommended to carry out a drug test for tolerance to it. To do this, the gel is applied in a thin layer to the skin of the elbow. The appearance of sharp redness and itching indicates an increased sensitivity to Dimexidum.

If allergic reactions occur during treatment with the drug, the use of the drug is discontinued, blockers of histamine H1 receptors are prescribed.

Overdose

Symptoms: increased dose-related side effects.

Treatment: the drug should be canceled, the damaged area should be washed, the drug should be removed.

Drug interactions

Compatible with heparin, antibacterial drugs, NSAIDs.

Increases the sensitivity of microorganisms to aminoglycoside and beta-lactam antibiotics, chloramphenicol, rifampicin, griseofulvin.

Storage conditions

The drug should be stored out of the reach of children at a temperature not exceeding 25 ? C.

Shelf life

Shelf life is 2 years. Do not use after the expiration date.

Terms of sale

The drug is dispensed without a prescription.