Diphenhydramine tablets 50mg, No. 20

• Allergic conjunctivitis, allergic rhinitis, chronic urticaria, itchy dermatoses, dermatographism, serum sickness;

• In the complex therapy of anaphylactic and anaphylactoid reactions, Quincke's edema and other allergic conditions.

• Insomnia, chorea, Meniere's syndrome, motion sickness and air sickness, as an antiemetic.

• Sunburns and 1st degree burns;

• Insect bites;

• Itching of various origins (with the exception of itching with cholestasis): eczema, chickenpox, allergic skin irritations, contact dermatitis caused by contact with plants.

The method of application and dosage regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.

Administered orally, parenterally and externally.

Inside appoint adults and children over 14 years of age in a single dose of 50 mg. The scheme and duration of use are determined individually, depending on the indications.

Active substance:

diphenhydramine

• Angle-closure glaucoma

• hypertrophy of the prostate gland,

• stenosing ulcer of the stomach and duodenum,

• bladder neck stenosis,

• bronchial asthma,

• epilepsy,

• hypersensitivity to diphenhydramine.

• children under 14 years of age (for oral administration);

With care: increased intraocular pressure, hyperthyroidism, arterial hypertension, diseases of the cardiovascular system, bronchopulmonary diseases.

pharmachologic effect

Blocker of histamine H1 receptors. It has antiallergic activity, has a local anesthetic, antispasmodic and moderate ganglion blocking effect. When taken orally, it causes a sedative and hypnotic effect, has a moderate antiemetic effect, and also has a central anticholinergic activity. When applied externally, it has an anti-allergic effect.

Pharmacokinetics

It is rapidly absorbed from the gastrointestinal tract. Bioavailability is 50%. Cmax is reached after 20-40 minutes (the highest concentration is determined in the lungs, spleen, kidneys, liver, brain and muscles). Plasma protein binding - 98-99%. Penetrates the BBB. It is metabolized mainly in the liver, partly in the lungs and kidneys. T1 / 2 - 4-10 hours. During the day, it is completely excreted by the kidneys in the form of metabolites conjugated with glucuronic acid. Significant amounts are excreted in milk and can cause sedation in infants (a paradoxical reaction characterized by excessive excitability can be observed).

Side effect

Possibly: short-term numbness of the oral mucosa, drowsiness, general weakness, a decrease in the speed of the psychomotor reaction; in children, paradoxical development of insomnia, irritability and euphoria is possible. Rarely: dizziness, headache, dry mouth, nausea, photosensitivity, accommodation paresis, impaired coordination of movements, tremor.

Application during pregnancy and lactation

During pregnancy and lactation (breastfeeding), diphenhydramine is used with caution, according to strict indications, in cases where the expected therapeutic effect for the mother outweighs the potential risk to the fetus or infant.

special instructions

Diphenhydramine is used with caution during pregnancy and lactation. During the period of treatment, one should not be exposed to sunlight, and alcohol should be avoided. Influence on the ability to drive vehicles and control mechanisms Use with caution in patients engaged in potentially hazardous activities that require increased attention and rapid psychomotor reactions.

Drug interactions

With simultaneous use, it enhances the effect of ethanol and drugs that depress the central nervous system. With simultaneous use, MAO inhibitors enhance the anticholinergic activity of diphenhydramine. Antagonistic interaction is noted when administered together with psychostimulants. Reduces the effectiveness of apomorphine as an emetic in the treatment of poisoning. Enhances the anticholinergic effects of drugs with anticholinergic activity.