Disulfiram | Teturam tablets 150 mg, 50 pcs.
Special Price
$18.62
Regular Price
$26.00
In stock
SKU
BID494852
Latin name
TETURAM
TETURAM
Latin name
TETURAM
release form
tablets
packaging 50 pcs
Pharmacological action
The drug is based on the blockade of acetaldehyde dehydrogenase, which is involved in the metabolism of ethyl alcohol.
This leads to an increase in the concentration of the metabolite of ethyl alcohol - acetaldehyde, which causes negative feelings (flushing, nausea, vomiting, tachycardia, lowering blood pressure (BP), etc.), which make drinking alcohol extremely unpleasant after taking Teturam.
This leads to a conditioned reflex aversion to the taste and smell of alcohol.
Indications
Treatment and prevention of relapse of chronic alcoholism.
As a detoxifying agent for chronic nickel poisoning.
Contraindications
Hypersensitivity, thyrotoxicosis, CVD diseases in the decompensation stage (including pronounced cardiosclerosis, cerebral arteriosclerosis, pre- and post-infarction conditions, aortic aneurysm, coronary insufficiency, II-arterial hypertension). pulmonary tuberculosis with hemoptysis, bronchial asthma, COPD, severe emphysema, erosive lesions of the gastrointestinal mucosa, gastric and duodenal ulcer (in the acute stage), gastrointestinal bleeding, kidney disease, liver failure, diabetes mellitus, epilepsy, neuropsychiatric diseases, central nervous system infections, polyneuropathy, neuritis of the auditory and optic nerves, glaucoma, malignant tumors, pregnancy, lactation. Caution. Age over 60 years, peptic ulcer of the stomach and duodenum (in remission), endarteritis, residual effects of cerebrovascular accident, psychosis with a history of disulfiram.
Use during pregnancy and lactation
Contraindicated during pregnancy and lactation.
Composition
1 tablet contains tetram 150 mg
Dosage and administration
Treatment is prescribed after a thorough examination of the patient and warning about the consequences and complications.
The drug is taken orally at 150-500 mg 2 times a day according to an individual scheme.
After 7-10 days, a teturamalcoholic test is carried out (20-30 ml of 40% vodka after taking 500 mg of the drug), with a weak reaction, the dose of alcohol is increased by 10-20 ml (the maximum dose of vodka is 100-120 ml).
The test is repeated after 1-2 days in the hospital and after 3-5 days on an outpatient basis, with the adjustment of doses of alcohol and / or the drug as necessary.
In the future, you can use a maintenance dose of 150-200 mg per day for 1-3 years.
Side effects
Metallic taste in the mouth, bad breath (due to carbon disulfide) in patients with colostomy, hepatitis, polyneuropathy of the lower extremities, neuropsychiatric disorders, memory loss, disorientation in time and space, asthenia, headache, allergic skin reactions.
Drug Interaction
Contraindications combinations
Alcohol: intolerance reaction (ebb, erythema, vomiting, tachycardia). Avoid taking alcoholic beverages and medicines containing alcohol.
Undesirable combinations
Isoniazid: impaired behavior and coordination.
Nitro-5-imidazoles (metronidazole, ordinazole, secnidazole, tinidazole): delirious disorders, confusion.
Phenytoin: A significant and rapid increase in plasma phenytoin levels with toxic symptoms (inhibition of its metabolism).
If the combination cannot be avoided, clinical monitoring and monitoring of the drug concentrations in the entry plasma and after treatment with teturam should be performed.
Combinations with caution
Warfarin (and other oral anticoagulants): increased effect of oral anticoagulants and risk of bleeding (decreased disintegration of warfarin in the liver). More frequent monitoring of warfarin concentration and dose adjustment of anticoagulants within 8 days after withdrawal of teturam is recommended.
Theophylline: teturam inhibits the metabolism of theophylline. As a result, the dose of theophylline should be adjusted (reduced dosage), depending on the clinical symptoms and the concentration of the drug in the plasma.
Benzodiazepines: teturates may potentiate the sedative effect of benzodiazepines by inhibiting their oxidative metabolism (especially chlordiazepoxide and diazepam). Benzodiazepine dosage should be adjusted according to clinical manifestations.
Tricyclic antidepressants: may increase the intolerance of alcohol intolerance (especially if patients are taking alcohol while taking teturam).
overdose
Symptoms: combination of teturam-ethanol can cause depression of consciousness up to coma, cardiovascular collapse, neurological complications.
Treatment: symptomatic.
Storage conditions
In the dark place at a temperature of no higher than 25 РC.
Expiration
4 years.
Active ingredient
Disulfiram
Pharmacy terms
Prescription
dosage form
dosage form PMA
TETURAM
release form
tablets
packaging 50 pcs
Pharmacological action
The drug is based on the blockade of acetaldehyde dehydrogenase, which is involved in the metabolism of ethyl alcohol.
This leads to an increase in the concentration of the metabolite of ethyl alcohol - acetaldehyde, which causes negative feelings (flushing, nausea, vomiting, tachycardia, lowering blood pressure (BP), etc.), which make drinking alcohol extremely unpleasant after taking Teturam.
This leads to a conditioned reflex aversion to the taste and smell of alcohol.
Indications
Treatment and prevention of relapse of chronic alcoholism.
As a detoxifying agent for chronic nickel poisoning.
Contraindications
Hypersensitivity, thyrotoxicosis, CVD diseases in the decompensation stage (including pronounced cardiosclerosis, cerebral arteriosclerosis, pre- and post-infarction conditions, aortic aneurysm, coronary insufficiency, II-arterial hypertension). pulmonary tuberculosis with hemoptysis, bronchial asthma, COPD, severe emphysema, erosive lesions of the gastrointestinal mucosa, gastric and duodenal ulcer (in the acute stage), gastrointestinal bleeding, kidney disease, liver failure, diabetes mellitus, epilepsy, neuropsychiatric diseases, central nervous system infections, polyneuropathy, neuritis of the auditory and optic nerves, glaucoma, malignant tumors, pregnancy, lactation. Caution. Age over 60 years, peptic ulcer of the stomach and duodenum (in remission), endarteritis, residual effects of cerebrovascular accident, psychosis with a history of disulfiram.
Use during pregnancy and lactation
Contraindicated during pregnancy and lactation.
Composition
1 tablet contains tetram 150 mg
Dosage and administration
Treatment is prescribed after a thorough examination of the patient and warning about the consequences and complications.
The drug is taken orally at 150-500 mg 2 times a day according to an individual scheme.
After 7-10 days, a teturamalcoholic test is carried out (20-30 ml of 40% vodka after taking 500 mg of the drug), with a weak reaction, the dose of alcohol is increased by 10-20 ml (the maximum dose of vodka is 100-120 ml).
The test is repeated after 1-2 days in the hospital and after 3-5 days on an outpatient basis, with the adjustment of doses of alcohol and / or the drug as necessary.
In the future, you can use a maintenance dose of 150-200 mg per day for 1-3 years.
Side effects
Metallic taste in the mouth, bad breath (due to carbon disulfide) in patients with colostomy, hepatitis, polyneuropathy of the lower extremities, neuropsychiatric disorders, memory loss, disorientation in time and space, asthenia, headache, allergic skin reactions.
Drug Interaction
Contraindications combinations
Alcohol: intolerance reaction (ebb, erythema, vomiting, tachycardia). Avoid taking alcoholic beverages and medicines containing alcohol.
Undesirable combinations
Isoniazid: impaired behavior and coordination.
Nitro-5-imidazoles (metronidazole, ordinazole, secnidazole, tinidazole): delirious disorders, confusion.
Phenytoin: A significant and rapid increase in plasma phenytoin levels with toxic symptoms (inhibition of its metabolism).
If the combination cannot be avoided, clinical monitoring and monitoring of the drug concentrations in the entry plasma and after treatment with teturam should be performed.
Combinations with caution
Warfarin (and other oral anticoagulants): increased effect of oral anticoagulants and risk of bleeding (decreased disintegration of warfarin in the liver). More frequent monitoring of warfarin concentration and dose adjustment of anticoagulants within 8 days after withdrawal of teturam is recommended.
Theophylline: teturam inhibits the metabolism of theophylline. As a result, the dose of theophylline should be adjusted (reduced dosage), depending on the clinical symptoms and the concentration of the drug in the plasma.
Benzodiazepines: teturates may potentiate the sedative effect of benzodiazepines by inhibiting their oxidative metabolism (especially chlordiazepoxide and diazepam). Benzodiazepine dosage should be adjusted according to clinical manifestations.
Tricyclic antidepressants: may increase the intolerance of alcohol intolerance (especially if patients are taking alcohol while taking teturam).
overdose
Symptoms: combination of teturam-ethanol can cause depression of consciousness up to coma, cardiovascular collapse, neurological complications.
Treatment: symptomatic.
Storage conditions
In the dark place at a temperature of no higher than 25 РC.
Expiration
4 years.
Active ingredient
Disulfiram
Pharmacy terms
Prescription
dosage form
dosage form PMA
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