Dona powder d / prig. solution for oral administration 1.5 g, No. 20

Primary and secondary osteoarthritis, osteochondrosis, spondyloarthrosis.

Inside. The contents of one sachet are dissolved in 200 ml of water, taken orally 1 time per day. The symptomatic effect occurs 2-3 weeks after the use of the drug. The duration and regimen of treatment are prescribed by the attending physician. The minimum course of therapy is 6 weeks.

Powder for preparation of oral solution, white, crystalline.

1 pack.

glucosamine sulfate sodium chloride 1884 mg,?

incl. glucosamine sulfate 1500 mg?

sodium chloride 384 mg

Excipients: aspartame, sorbitol, carbovax 4000 (macrogol 4000), citric acid.

• Individual hypersensitivity to glucosamine sulfate, aspartame and other components of the drug. Due to the content of aspartame, it is contraindicated in patients with phenylketonuria.

• It is not recommended to prescribe the drug during pregnancy and lactation, as well as in childhood (up to 12 years) due to the lack of scientific clinical data in this category of patients.

pharmachologic effect

DonaЃ has anti-inflammatory and analgesic effects, replenishes endogenous glucosamine deficiency, stimulates the synthesis of proteoglycans and hyaluronic acid in synovial fluid; increases the permeability of the joint capsule, restores enzymatic processes in the cells of the synovial membrane and articular cartilage. Promotes sulfur fixation during the synthesis of chondroitinsulfuric acid, facilitates the normal deposition of calcium in bone tissue, inhibits the development of degenerative processes in the joints, restores their function, reducing joint pain.

Pharmacokinetics

Absorption in the gastrointestinal tract - 90%, bioavailability 25%, T1 / 2 - 70 hours.

Side effect

The drug is well tolerated, in some cases the following are possible: gastralgia, flatulence, nausea, diarrhea, constipation; headache, drowsiness; allergic reactions - erythema, urticaria, itching.

Application during pregnancy and lactation

It is not recommended to prescribe the drug during pregnancy and lactation due to the lack of scientific clinical data in this category of patients.

Application for violations of liver function

When using the drug in patients with severe hepatic impairment, medical supervision is required.

Application for impaired renal function

Contraindicated in severe chronic renal failure. When using the drug in patients with severe renal failure, medical supervision is required.

Application in children

Contraindicated in children under 12 years of age.

special instructions

When using the drug in patients with impaired glucose tolerance, with severe hepatic and renal failure, medical supervision is required.

Overdose

Overdose cases are unknown.

Treatment: gastric lavage, symptomatic therapy.

Drug interactions

Compatible with NSAIDs, paracetamol and glucocorticosteroids. Increases the absorption of tetracyclines, reduces - semi-synthetic penicillins, chloramphenicol.