Dona tablets 750mg, No. 60

Osteoarthritis of the peripheral joints and spine, osteochondrosis.

Inside. 1 tablet of 750 mg is taken orally 2 times a day, preferably with meals, with a glass of water. The symptomatic effect occurs 2-3 weeks after the use of the drug. The minimum course of therapy is 4-6 weeks.

If necessary, the course of treatment is repeated at intervals of 2 months. The duration and regimen of treatment are prescribed by the attending physician.

If after treatment there is no improvement or symptoms worsen, or new symptoms appear, you should consult your doctor. Use the drug only according to the indications, the route of administration and the doses indicated in the instructions.

Tablets, film-coated white, oblong, oval; the cross section shows two layers - the outer one is white, the inner one is white with a yellowish or brownish tint.

1 tab.

glucosamine sulfate sodium chloride 942 mg,

incl. glucosamine sulfate 750 mg

sodium chloride 192 mg

Excipients: microcrystalline cellulose - 68 mg, povidone K25 (polyvinylpyrrolidone K25) - 45 mg, croscarmellose sodium - 20 mg, macrogol 6000 (polyethylene glycol 6000) - 15 mg, magnesium stearate - 8.5 mg, talc - 1.5 mg.

• Individual hypersensitivity to the active substance and other components of the drug,

• severe chronic renal failure.

• It is not recommended to prescribe the drug during pregnancy and during breastfeeding, as well as in childhood (up to 18 years) due to the lack of scientific clinical data in this category of patients.

pharmachologic effect

DonaЃ has anti-inflammatory and analgesic effects, replenishes endogenous glucosamine deficiency, stimulates the synthesis of proteoglycans and hyaluronic acid in synovial fluid; increases the permeability of the joint capsule, restores enzymatic processes in the cells of the synovial membrane and articular cartilage. Promotes sulfur fixation during the synthesis of chondroitinsulfuric acid, facilitates the normal deposition of calcium in bone tissue, inhibits the development of degenerative processes in the joints, restores their function, reducing joint pain.

Pharmacokinetics

Absorption in the gastrointestinal tract - 90%, bioavailability 25%, T1 / 2 - 70 hours.

Side effect

The drug is well tolerated, in some cases the following are possible: gastralgia, flatulence, nausea, diarrhea, constipation; headache, drowsiness; allergic reactions - erythema, urticaria, itching.

Application during pregnancy and lactation

It is not recommended to prescribe the drug during pregnancy and lactation due to the lack of scientific clinical data in this category of patients.

Application for violations of liver function

When using the drug in patients with severe hepatic impairment, medical supervision is required.

Application for impaired renal function

Contraindicated in severe chronic renal failure. When using the drug in patients with severe renal failure, medical supervision is required.

Application in children

Contraindicated in children under 12 years of age.

special instructions

Precautions for use

Caution should be exercised in patients allergic to seafood (shrimp, shellfish).

The drug contains 75.5 mg sodium per tablet, which should be taken into account in patients on a controlled sodium diet.

Take with caution in bronchial asthma and diabetes mellitus.

When using the drug in patients with impaired glucose tolerance, with severe hepatic and renal failure, medical supervision is required.

Influence on the ability to drive vehicles and mechanisms

Absent.

Overdose

Overdose cases are unknown.

Treatment: gastric lavage, symptomatic therapy.

Drug interactions

Compatible with NSAIDs, paracetamol and glucocorticosteroids. Increases the absorption of tetracyclines, reduces - semi-synthetic penicillins, chloramphenicol; enhances the effect of coumarin anticoagulants.