Dorithricin lozenges, no. 10

Symptomatic treatment of infectious and inflammatory diseases of the oral cavity and throat accompanied by pain:

- pharyngitis, laryngitis, tonsillitis;

- inflammation of the gums and oral mucosa (gingivitis stomatitis).

Inside. For adults and children over 6 years of age, slowly dissolve in the mouth, 1 tablet every 3 hours. The maximum daily dose is 6 tablets. The course of treatment is 7 days. An increase in the course of therapy, if necessary, on the recommendation of a doctor. It is not recommended to eat and chew chewing gum within 1 hour after using the drug or until numbness in the mouth and throat is felt, as there is a risk of aspiration and damage to the oral mucosa. If the patient's condition does not improve after 2-3 days of using the drug, it is necessary to consult a doctor.

1 tablet contains:

Active substances:

benzocaine 1.50 mg

benzalkonium chloride 1.00 mg

tyrothricin 0.50 mg

Excipients: sorbitol 871.00 mg, talc 80, 00 mg, povidone-25 thousand 10.00 mg, sodium carmellose 10.00 mg, sucrose stearate 20.00 mg, peppermint oil 5.00 mg, sodium saccharinate 1.00 mg

• Hypersensitivity to benzalkonium chloride, benzocaine tyrothrins, para-aminobenzoic acid, quaternary ammonium compounds, any other component of the drug;

• hereditary fructose intolerance and glucose / galactose malabsorption syndrome or sucrase / isomaltase deficiency (due to the presence of sucrose in the preparation);

• fresh wounds in the mouth and throat, including immediately after maxillofacial surgery of dental procedures;

• children under 6 years of age.

Trade name of the drug

DorithricinЃ

Dosage form

Lozenges

Composition

1 tablet contains:

Active substances:

benzocaine 1.50 mg

benzalkonium chloride 1.00 mg

tyrothricin 0.50 mg

Excipients: sorbitol 871.00 mg, talc 80, 00 mg, povidone-25 thousand 10.00 mg, sodium carmellose 10.00 mg, sucrose stearate 20.00 mg, peppermint oil 5.00 mg, sodium saccharinate 1.00 mg

Description

Round, beveled, flat-cylindrical tablets, marked DOR1THR1CIN on one side, white with a mint odor.

Pharmacotherapeutic group

Antiseptic + local anesthetic

Pharmacodynamics:

The combined preparation has an antiseptic and local anesthetic effect. Reduces irritation and sore throat and swelling of the oral mucosa.

Benzocaine is a local anesthetic that relieves pain when swallowing, which often accompanies infectious and inflammatory processes in the mouth and throat.

Benzalkonium chloride - an antiseptic that disrupts the permeability of the cell membrane of microorganisms and inhibits enzymatic processes is active against many pathogenic bacteria, some types of viruses of fungi and protozoa.

Tyrothricin is a local antibiotic. It is active against a wide range of gram-positive microorganisms and oral spirochetes. Due to the special mechanism of action of tyrothricin, which is absent in antibiotics of systemic action, cross-resistance to the drug does not arise.

Pharmacokinetics:

Benzocaine is slightly soluble in water, which causes poor absorption in the intestine. It is cleaved by enzymes in blood plasma and is metabolized in a small amount in the liver. It is excreted by the kidneys.

Benzalkonium chloride is practically not absorbed in the intestine and has no resorptive effect. It is excreted by the kidneys.

Tyrothricin - due to low systemic absorption, there are no pharmacokinetic data. Does not affect the intestinal microflora.

Indications:

Symptomatic treatment of infectious and inflammatory diseases of the oral cavity and throat accompanied by pain:

- pharyngitis, laryngitis, tonsillitis;

- inflammation of the gums and oral mucosa (gingivitis stomatitis).

Contraindications:

• Hypersensitivity to benzalkonium chloride, benzocaine tyrothrins, para-aminobenzoic acid, quaternary ammonium compounds, any other component of the drug;

• hereditary fructose intolerance and glucose / galactose malabsorption syndrome or sucrase / isomaltase deficiency (due to the presence of sucrose in the preparation);

• fresh wounds in the mouth and throat, including immediately after maxillofacial surgery of dental procedures;

• children under 6 years of age.

Pregnancy and lactation:

The use of the drug DoritricinЃ during pregnancy and during breastfeeding is possible only after consulting a doctor to determine the excess of the expected benefit for the mother to the potential risk to the fetus and child.

Method of administration and dosage:

Inside. For adults and children over 6 years of age, slowly dissolve in the mouth, 1 tablet every 3 hours. The maximum daily dose is 6 tablets. The course of treatment is 7 days. An increase in the course of therapy, if necessary, on the recommendation of a doctor. It is not recommended to eat and chew chewing gum within 1 hour after using the drug or until numbness in the mouth and throat is felt, as there is a risk of aspiration and damage to the oral mucosa. If the patient's condition does not improve after 2-3 days of using the drug, it is necessary to consult a doctor.

Side effects:

Allergic reactions, gastrointestinal disturbances (nausea and diarrhea) are possible. Allergic reactions: itchy skin rash edema of the mucous membrane of the mouth and throat anaphylactic reactions; a burning sensation, tingling sensation in the mouth and throat; convulsions tachycardia dermatitis. It is possible to decrease the sensitivity of the mucous membrane of the mouth and throat. After topical application, in particular with the presence of large wounds in the mouth and throat, especially in children, it is possible to develop methemoglobinemia, which is manifested by shortness of breath with a bluish color of the lips and fingers. Tyrothricin may cause bleeding if fresh wounds are present. Sensitized patients may develop hypersensitivity reactions caused by peppermint oil (including shortness of breath).In susceptible patients, allergic reactions are possible due to substances that are chemically related to benzocaine, such as penicillins sulfonamides, cosmetic sunscreen. If any of the side effects indicated in the instructions are aggravated or you notice any other side effects not indicated in the instructions, inform your doctor.

Overdose:

In the recommended doses, cases of overdose have not been described. Accidental intake of large doses of DoritricinЃ can cause disorders of the digestive system (nausea, vomiting, diarrhea), methemoglobinemia (difficulty breathing and bluish skin color). In this case, it is necessary to rinse the stomach with activated charcoal and consult a doctor.

Interaction:

Cases of clinically significant interactions of DoritricinЃ with other drugs have not been described.

Special instructions:

Information for patients with diabetes mellitus: in 1 tablet of the drug, the carbohydrate content is ~ 007 bread units (XE). For children over 6 years old, the use of the drug is recommended only for medical reasons. In severe sore throat (sore throat accompanied by high body temperature, headache, nausea or vomiting), you should consult a doctor. In case of a known hypersensitivity reaction of the skin (allergic contact dermatitis), the use of the drug should be avoided due to the possibility of developing a hypersensitivity reaction. It is necessary to observe the interval within 1 hour between the use of the drug and the use of toothpaste, since the antibacterial effect of the drug may decrease. Sorbitol may have a mild laxative effect.

Impact on the ability to drive vehicles. Wed and fur .:

Does not affect.

Release form / dosage:

Lozenges.

Packaging:

10 tablets in a blister made of PVC film and aluminum foil. 1 blister with instructions for use in a cardboard box.

Storage conditions:

At room temperature not higher than 25 ? — in a dry, dark place. Keep out of the reach of children!

Shelf life:

5 years.

Do not use after the expiration date.

Vacation conditions

Without recipe

Manufacturer

Rimser Specialty Production GmbH, Vorholzweg 16, 88471 Laupheim, Germany, Germany