Doxazosin | Doxazosin-Teva tablets 4 mg 30 pcs.

Indications

Arterial hypertension (monotherapy and in combination with other antihypertensive agents: thiazide diuretics, beta-blockers, calcium channel blockers or ACE inhibitors), benign prostatic hyperplasia (in the presence of arterial hypertension and.

Contraindications

Hypersensitivity, pregnancy, breast-feeding, age up to 18 years.

Composition

Active ingredient: doxazosin mesylate 4 mg

Dosage and administration

Inside, regardless of food intake, without chewing and drinking plenty of water, Once a day (morning or evening).

For arterial hypertension: doses vary from 1 to 16 mg / day (maximum), the initial dose is 1 mg 1 time per day (at bedtime), after which the patient should be in bed for 6-8 hours (the development of the Ԧirst doses ", especially expressed against the background of the previous intake of diuretics). If the therapeutic effect is insufficient, the daily dose is increased to 2 mg only after 1ֲ weeks of continuous treatment, then with an interval of 1ֲ, the sub-dose is increased by 2 mg until the optimal therapeutic effect is achieved. Pic especially pronounced against the background of previous administration of diuretics). If the therapeutic effect is insufficient, the daily dose is increased to 2 mg only after 1ֲ weeks of continuous treatment, then with an interval of 1ֲ, the sub-dose is increased by 2 mg until the optimal therapeutic effect is achieved. Pic especially pronounced against the background of previous administration of diuretics). If the therapeutic effect is insufficient, the daily dose is increased to 2 mg only after 1ֲ weeks of continuous treatment, then with an interval of 1ֲ, the sub-dose is increased by 2 mg until the optimal therapeutic effect is achieved. PicTo achieve a stable therapeutic effect, the dose is usually reduced (the average therapeutic dose with maintenance therapy is 2ִ mg / day).

In benign prostatic hyperplasia without arterial hypertension: usually 2ִ mg / day, maximum dose 8 mg / day.

Side effects of

When using doxazosin, especially at the beginning of treatment, orthostatic hypotension is most often observed, which in rare cases can lead to fainting. In order to prevent orthostatic hypotension, patients should avoid sudden and abrupt changes in body position (transition from a lying position to a standing position).

It may be noted: headache, dizziness, general feeling of weakness, fatigue, drowsiness, rhinitis, nausea. In patients with arterial hypertension rarely noted: tachycardia, arrhythmia, chest pain, angina attacks, myocardial infarction, cerebrovascular disorders.

There have been isolated cases of allergic reactions (skin rash, jaundice, thrombocytopenic purpura, increased transaminases), dry mouth, nosebleeds, priapism, urinary incontinence, increased appetite, constipation, increased urine output, myalgia, arthralgia.

Drug Interactions

Enhances the antihypertensive effect of antihypertensive drugs. Compatible with thiazide diuretics, furosemide, beta-blockers, calcium channel blockers, ACE inhibitors, antibiotics, oral hypoglycemic agents, indirect anticoagulants and uricosuric agents. When combined with inducers of microsomal oxidation in the liver, an increase in the effect is possible, with inhibitors, a decrease. NSAIDs (especially indomethacin), estrogens, and sympathomimetic drugs lower the hypotensive effect. Reduces the pressor effect of ephedrine. Eliminating the alpha-adrenostimulating effects of epinephrine, can lead to a distortion of its pressor action and the development of tachycardia.

Overdose

Symptoms: marked decrease in blood pressure, sometimes accompanied by fainting.

Treatment: it is necessary to transfer the patient to a horizontal position (lower your head down, raise your legs), symptomatic therapy.

Storage Conditions

In a dark place at 5-25 РC.

Deystvuyuschee substances

doxazosin

Conditions of supply of

Pharmacy Prescription

Dosage form

tablet

Teva Pharmaceutical Enterprises Co., Ltd., Israel