Endokol-G 1l

DESCRIPTION

Endocol-g (Endocolum-g) is a complex antimicrobial drug for the prevention of postpartum diseases of the uterus and treatment of endometritis. In appearance, the drug is a clear, colorless or pale yellow to yellow liquid.

COMPOSITION

1.0 ml of the drug contains 90,000 IU of colistin sulfate, 3.0 mg of gentamicin sulfate, 1.7 mg of propranolol hydrochloride, excipients and solvent up to 1.0 ml.

PHARMACOLOGICAL PROPERTIES

Endokol-g is a complex antimicrobial drug. Has a bactericidal effect against gram-positive and gram-negative microorganisms, including Escherichia coli, Salmonella spp., Staphylococcus spp., Bordetella spp., Klebsiella spp., Pasteurella spp., Pseudomonas aeruginosa and others.

Gentamicin sulfate has a broad spectrum of antimicrobial action against most gram-positive and some gram-negative microorganisms, including Escherichia coli, Proteus spp., Salmonella spp. and Staphylococcus spp.

The mechanism of the bactericidal action of gentamicin is due to binding to the 30S-subunit of ribosomes and disruption of protein synthesis, thereby preventing the formation of a complex of transport and messenger RNA, while RNA is incorrectly read and non-functional proteins are formed. In high concentrations, it reduces the barrier function of the cytoplasmic membranes and causes the death of microorganisms.

Colistin sulfate is active against many gram-negative microorganisms, including Escherichia coli, Pseudomonas aeruginosa, Klebsiella spp., Salmonella spp., Corynebacterium spp., Clostridium spp., Pasteurella spp., Bacteroides spp.

The mechanism of the bactericidal action of colistin is the destruction of the structure of the phospholipids of the cell membrane, which causes the death of the microorganism.

Propranolol hydrochloride, which is part of the drug, enhances the contractility of the myometrium, which contributes to a faster separation of the placenta, and in case of endometritis, the removal of purulent contents from the uterus.

The components of the drug are poorly absorbed through the mucous membrane of the uterus, which prevents their accumulation in animal products and milk. In recommended doses, it does not have a local irritant, resorptive-toxic, mutagenic and sensitizing effect.

DOSAGE AND APPLICATION

The drug is used in cows for the prevention of postpartum diseases of the uterus and treatment of endometritis.

Before the introduction of the drug, the external genital organs are treated. If necessary, empty the uterine cavity from the contents.

When treating animals with various forms of endometritis, the drug is administered intrauterinely at a dose of 50.0 - 150.0 ml using a Janet syringe with an interval of 24 - 48 hours until clinical recovery. The course of treatment is 3 - 5 injections. In chronic and subclinical endometritis, rectal massage of the uterus should be performed for 1.5 - 2 minutes before the administration of the drug.

For the prevention of postpartum diseases, the drug is used once intrauterinely at a dose of 50.0 - 150.0 ml with the help of Janet's syringe after separation of the placenta, abortion or assistance in complications and pathological childbirth.

Avoid skipping the next dose of the drug, as this can lead to a decrease in therapeutic effectiveness.

SPECIAL INSTRUCTIONS

Simultaneous use of the drug with drugs containing xylazine, medetomidine and detomidine is not allowed.

Milk obtained from animals during the treatment period and within three days after the last use of the drug should not be used for food purposes. Slaughter of animals for meat is allowed no earlier than four days after the last use of the drug. The meat of animals that were forcedly killed before the expiration of the specified period can be used for feeding fur-bearing animals.

CONTRAINDICATIONS

The use of the drug is contraindicated in animals with increased individual sensitivity to the components of the drug.

SIDE EFFECTS

Allergic reactions are possible when using the drug. If they occur, the drug should be discontinued and antihistamines (allervet, diprazine) and calcium preparations (calcium gluconate or calcium chloride) should be used.

SHELF LIFE AND STORAGE

The drug is stored according to list B in a dry, dark place at a temperature from plus 5 В° C to plus 25 В° C. The shelf life of the drug is 1 year from the date of manufacture, subject to the rules of storage and transportation.

PACKAGING

The drug is produced in a plastic container with a volume of 1000 ml.

Specifications

KolVUP

12

Manufacturer

Belarus

Temperature regime

from +5 to +25

Teaser

for the prevention of postpartum diseases of the uterus and treatment of endometritis