Enzistal tablets p / o, No. 40

• Lack of exocrine pancreatic function in cystic fibrosis, chronic pancreatitis;

• after pancreatectomy;

• when the pancreatic duct is compressed by a tumor;

• steatorrhea with malabsorption syndrome;

• conditions after gastrectomy, dyspepsia in case of inaccuracies in nutrition;

• in chronic diseases of the digestive system (especially in the elderly) and in patients who are on prolonged bed rest,

• preparation for X-ray and ultrasound examination of the abdominal organs.

Enzistal is taken orally, without chewing, during or immediately after a meal, with a small amount of liquid.

Adults - 1-2 tablets 3 times a day. Higher doses are prescribed by your doctor.

Children over 6 years old (as prescribed by a doctor) - 1 tablet 2-3 times a day.

The duration of treatment can vary from several days (if the digestive process is disturbed due to inaccuracies in nutrition) to several months or years (if constant replacement therapy is necessary).

Before X-ray or ultrasound examination - 2 tablets 2-3 times a day for 2-3 days before the examination.

Each tablet contains:

Active substances:

pancreatin -192.00 mg (protease activity: at least 300 MFP units, lipase activity: at least 6000 MFP units, amylase activity: at least 4500 MFP units),

bovine bile extract - 25.00 mg,

hemicellulase - 50.00 mg.

Excipients:

lactose monohydrate - 67.30 mg, magnesium stearate - 4.00 mg, colloidal silicon dioxide - 1.70 mg,

Enteric coating:

cellacephate - 21.61 mg, diethyl phthalate - 3.89 mg,

Sugar shell: sucrose - 114.209 mg, calcium carbonate - 67.73 mg, talc - 33.369 mg, acacia gum - 4.278 mg, gelatin - 4.278 mg, titanium dioxide - 0.422 mg, yellow beeswax - 0.114 mg.

• Hypersensitivity to the components of the drug,

• acute pancreatitis,

• exacerbation of chronic pancreatitis,

• liver failure,

• hepatitis,

• obstructive jaundice

• cholelithiasis,

• empyema of the gallbladder,

• intestinal obstruction,

• children under 6 years old,

• cholelithiasis.

Trade name of the drug:

ENZYSTALЃ

Dosage form:

enteric-coated tablets

Composition:

Each tablet contains:

Active substances:

pancreatin -192.00 mg (protease activity: at least 300 MFP units, lipase activity: at least 6000 MFP units, amylase activity: at least 4500 MFP units),

bovine bile extract - 25.00 mg,

hemicellulase - 50.00 mg.

Excipients:

lactose monohydrate - 67.30 mg, magnesium stearate - 4.00 mg, colloidal silicon dioxide - 1.70 mg,

Enteric coating:

cellacephate - 21.61 mg, diethyl phthalate - 3.89 mg,

Sugar shell: sucrose - 114.209 mg, calcium carbonate - 67.73 mg, talc - 33.369 mg, acacia gum - 4.278 mg, gelatin - 4.278 mg, titanium dioxide - 0.422 mg, yellow beeswax - 0.114 mg.

Description

White, round, biconvex, sugar-coated tablets.

Pharmacotherapeutic group:

digestive enzyme

Pharmacological properties

Combined drug, the action of which is due to the components that make up its composition. EnzistalЃ has a protective membrane that does not dissolve before entering the small intestine, which protects enzymes from the destructive action of gastric juice. EnzistalЃ promotes rapid and complete digestion of food, relieves symptoms resulting from digestive disorders (feeling of heaviness and fullness of the stomach, flatulence, shortness of breath due to gas in the intestines, diarrhea).
The enzymes included in pancreatin - amylase, lipase and protease - facilitate the digestion of carbohydrates, fats and proteins, which contributes to their more complete absorption in the small intestine.
Hemicellulase is an enzyme that promotes the breakdown of plant fiber, which also improves digestive processes, reduces the formation of gases in the intestines.
Bile extract acts as a choleretic, promotes the emulsification of fats, increases lipase activity, improves the absorption of fats and fat-soluble vitamins A, D, E, K.

Indications for use

• Lack of exocrine pancreatic function in cystic fibrosis, chronic pancreatitis;

• after pancreatectomy;

• when the pancreatic duct is compressed by a tumor;

• steatorrhea with malabsorption syndrome;

• conditions after gastrectomy, dyspepsia in case of inaccuracies in nutrition;

• in chronic diseases of the digestive system (especially in the elderly) and in patients who are on prolonged bed rest,

• preparation for X-ray and ultrasound examination of the abdominal organs.

Contraindications

• Hypersensitivity to the components of the drug,

• acute pancreatitis,

• exacerbation of chronic pancreatitis,

• liver failure,

• hepatitis,

• obstructive jaundice

• cholelithiasis,

• empyema of the gallbladder,

• intestinal obstruction,

• children under 6 years old,

• cholelithiasis.

With care : cystic fibrosis.

Method of administration and dosage

Enzistal is taken orally, without chewing, during or immediately after a meal, with a small amount of liquid.

Adults - 1-2 tablets 3 times a day. Higher doses are prescribed by your doctor.

Children over 6 years old (as prescribed by a doctor) - 1 tablet 2-3 times a day.

The duration of treatment can vary from several days (if the digestive process is disturbed due to inaccuracies in nutrition) to several months or years (if constant replacement therapy is necessary).

Before X-ray or ultrasound examination - 2 tablets 2-3 times a day for 2-3 days before the examination.

Side effect

Allergic reactions, nausea, diarrhea, abdominal pain, decreased endogenous synthesis of bile acids.

With prolonged use in high doses, it is possible to develop hyperuricosuria, an increase in the level of uric acid in the blood plasma.

In children, when using high doses, it is possible to develop perianal irritation and irritation of the oral mucosa.

Overdose

Symptoms: hyperuricemia and hyperuricuria.
Treatment: drug withdrawal, symptomatic therapy.

Interaction with other medicinal products

With simultaneous use with EnzistalЃ, absorption of PASK, sulfonamides, antibiotics is enhanced; a decrease in the absorption of iron preparations is possible.
The simultaneous use of antacids containing calcium carbonate and / or magnesium hydroxide can lead to a decrease in the effectiveness of Enzistal.
Cimetidine enhances the effect of the drug.

special instructions

In case of cystic fibrosis, the drug should be prescribed with caution, because the dose should be adequate to the quantity and quality of the food consumed.

Application during pregnancy and lactation

During pregnancy and lactation, the drug is prescribed only if the expected benefit to the mother outweighs the potential risk to the fetus or child.

Release form

Enteric-coated tablets. 10 tablets in Al / Al. blister. 2, 4 or 8 blisters of 10 tablets with instructions for use are packed in a cardboard box.

Storage conditions

Store at a temperature not exceeding 25 ? C in a dry, dark place.
Keep out of the reach of children.

Shelf life

3 years. Do not use after the expiration date printed on the package.

Conditions of dispensing from pharmacies

Without a doctor's prescription