Furamag capsules 50mg, No. 30

Infections caused by microorganisms sensitive to furazidine: urogenital infections (acute cystitis, urethritis, pyelonephritis), skin and soft tissue infections, severe infected burns, gynecological infections. Prophylactically can be used in urological operations, cystoscopy, catheterization, etc.

The drug is taken after meals with plenty of liquid.
Adults are prescribed 50-100 mg (2-4 capsules) 3 times a day.
Children are prescribed 25-50 mg (1-2 capsules) 3 times a day, but not more than 5 mg / kg of body weight per day. The course of treatment is 7-10 days. If necessary, after a 10-15 day break, the course is repeated.
For the prevention of infection during urological operations, cystoscopy, catheterization, etc. the drug is prescribed: for adults , 50 mg once 30 minutes before the procedure; children 25 mg once 30 minutes before the procedure. If you forget to take your next dose, take the next dose at the usual time. Do not take a double dose to replace a missed dose.

Active ingredient: potassium furazidine 50 mg;
Excipients - magnesium hydroxycarbonate, potassium carbonate, talc.
The composition of the capsule No. 4 - titanium dioxide (E 171), iron dye yellow oxide (E 172), gelatin.

Hypersensitivity to drugs of the nitrofuran group, pregnancy and lactation. Severe chronic renal failure. Children under 3 years of age (for this dosage form).

With care: deficiency of glucose-6-phosphate dehydrogenase.

Trade name of the drug: FuramagЃ

INN or Generic Name: furazidine &

Dosage form:

capsules.

Composition
Active ingredient: potassium furazidine 50 mg;
Excipients - magnesium hydroxycarbonate, potassium carbonate, talc.
The composition of the capsule No. 4 - titanium dioxide (E 171), iron dye yellow oxide (E 172), gelatin.

Description
Hard gelatin capsules No. 4, brownish-yellow color.
Contents of capsules: powder from orange-brown to reddish-brown, white, yellow, orange and orange-brown particles are allowed.

Pharmacotherapeutic group:

antimicrobial agent nitrofuran.

Pharmacological properties.

Pharmacodynamics.
Antimicrobial agent of a wide spectrum of action, belonging to the group of nitrofurans.
Resistance to FuramagЃ develops slowly and does not reach a high degree. Active against gram-positive and gram-negative microbes, pathogenic strains of Staphylococcus spp. and other antibiotic-resistant microorganisms. Effective against gram-positive cocci (streptococci, staphylococci), gram-negative rods (Escherichia coli, Salmonella, Shigella, Proteus, Klebsiella, Enterobacteriaceae), protozoa (Giardia). In relation to staphylococci, E. coli, Aerobacter aerogenes, Bact. Citrovorum, Proteus mirabilis, Proteus morganii FuramagЃ, in comparison with other nitrofurans, is more active. FuramagЃ is more active against Enterococcus faecalis, Staphylococcus spp. compared with other groups of antimicrobial drugs.
Against most bacteria, the bacteriostatic concentration ranges from 1: 100,000 to 1: 200,000. The bactericidal concentration is approximately twice as high. Under the influence of nitrofurans in microorganisms, the respiratory chain and the tricarboxylic acid cycle (Krebs cycle) are suppressed, as well as other biochemical processes of microorganisms are suppressed, as a result of which their membrane or cytoplasmic membrane is destroyed. As a result of the action of nitrofurans, microorganisms secrete less toxins, and therefore an improvement in the general condition of the patient is possible even before the pronounced suppression of the growth of microflora. Nitrofurans, unlike many other antimicrobial agents, not only do not suppress the body's immune system, but, on the contrary, activate it (increase the complement titer and the ability of leukocytes to phagocytose microorganisms).Nitrofurans in therapeutic doses stimulate leukopoiesis.

Pharmacokinetics.
Absorption takes place in the small intestine by passive diffusion. The absorption of nitrofurans from the distal segment of the small intestine exceeds the absorption from the proximal and middle segment, respectively, 2 and 4 times (should be taken into account when treating urogenital infections and diseases of the gastrointestinal tract, including chronic enteritis). Nitrofurans are poorly absorbed in the colon.
FuramagЃ, being a mixture of potassium furazidin and magnesium hydroxycarbonate in a 1: 1 ratio, when administered orally, has a higher bioavailability than simple furazidine (after taking the FuramagЃ capsule in the acidic environment of the stomach, the conversion of furazidine potassium into poorly soluble furazidine does not occur).
In the body, furazidine is evenly distributed. Clinically important is the high content of the active substance in the lymph (it delays the spread of infection through the lymphatic tract). Its concentration in bile is several times higher than in blood serum, and in cerebrospinal fluid it is several times lower than in serum. In saliva, the content of furazidine is 30% of its concentration in the blood serum. The concentration of furazidine in the blood and tissues is relatively low, which is associated with its rapid release, while the concentration in the urine is much higher than in the blood. The maximum concentration in the blood lasts from 3 to 7 or 8 hours, in urine furazidine is found 3-4 hours after application.
Unlike nitrofurantoin (furadonin), urine pH does not change after taking FuramagЃ. 4 hours after taking the drug FuramagЃ, the concentration of furazidine in the urine significantly exceeds the concentration that is formed after taking the same dose of the drug Furagin. Excretion through the kidneys occurs by glomerular filtration and tubular secretion (85%), partially undergoes reverse reabsorption in the tubules. At low concentrations of furazidine in urine, the process of filtration and secretion predominates, at high concentrations, secretion decreases and reabsorption increases. Furazidine, being a weak acid, does not dissociate in acidic urine, undergoes intensive reabsorption, which can increase the development of systemic side effects. With alkalization of urine, the excretion of furazidine is enhanced.The active substance of the drug is slightly biotransformed (less than 10% of the administered dose), with a decrease in renal excretory function, the metabolic rate increases.

Indications for use
Infections caused by microorganisms sensitive to furazidine: urogenital infections (acute cystitis, urethritis, pyelonephritis), skin and soft tissue infections, severe infected burns, gynecological infections. Prophylactically can be used in urological operations, cystoscopy, catheterization, etc.

Contraindications
Hypersensitivity to drugs of the nitrofuran group, pregnancy and lactation. Severe chronic renal failure. Children under 3 years of age (for this dosage form).

With care: deficiency of glucose-6-phosphate dehydrogenase.

Method of administration and dosage.
The drug is taken after meals with plenty of liquid.
Adults are prescribed 50-100 mg (2-4 capsules) 3 times a day.
Children are prescribed 25-50 mg (1-2 capsules) 3 times a day, but not more than 5 mg / kg of body weight per day. The course of treatment is 7-10 days. If necessary, after a 10-15 day break, the course is repeated.
For the prevention of infection during urological operations, cystoscopy, catheterization, etc. the drug is prescribed: for adults , 50 mg once 30 minutes before the procedure; children 25 mg once 30 minutes before the procedure. If you forget to take your next dose, take the next dose at the usual time. Do not take a double dose to replace a missed dose.

Overdose.
In case of an overdose, symptoms of a neurotoxic nature, ataxia and tremor are observed.
In case of poisoning, drink plenty of fluids. Antihistamines are used to relieve acute symptoms. For the prevention of neuritis, it is possible to prescribe vitamins (thiamine bromide).

Side effect.
FuramagЃ is low-toxic. Side effects characteristic of other nitrofurans were rarely observed: headache, dizziness, nausea, vomiting, loss of appetite, polyneuritis, liver dysfunction, allergic reactions (skin rash, papular rash).
If during the period of treatment with FuramagЃ side effects are found that are not indicated in the instructions, then it is necessary to inform the attending physician.
No effect on the ability to drive a vehicle was noted.
Drug interactions. FuramagЃ should not be used simultaneously with ristomycin, chloramphenicol, sulfonamides (the risk of hematopoiesis inhibition increases).
During the period of treatment, it is advisable to refrain from drinking alcoholic beverages, because side effects may increase.
It is not recommended to prescribe simultaneously with nitrofurans drugs that can 'acidify' urine (including ascorbic acid, calcium chloride).

Special instructions
To reduce the likelihood of side effects, FuramagЃ is taken with plenty of liquid. When side effects appear, the use of the drug is discontinued (toxic effects are more often manifested in patients with reduced renal excretory function).

Release form.
Capsules 25 mg. 10 capsules in a blister strip packaging. For 2,3,4 or 5 blister packs, together with instructions for use, are placed in a carton box.

Storage conditions
In a dry, dark place at a temperature not exceeding 25 ? C.
Keep out of the reach of children.

Shelf life is
3 years.
Do not use the drug after the expiration date.

Terms of dispensing from pharmacies:

with a doctor's prescription.