Indovazin gel for external use, 45 g

• Bursitis,

• tenosynovitis,

• synovitis

• phlebeurysm,

• hemorrhoids,

• traumatic hematoma,

• condition after prolonged immobilization.

Outwardly.

Squeeze out 1-2 cm of gel from the tube and apply with light rubbing movements on the affected areas 2-3 times a day.

Gel for external use from yellow to yellow-brown color, with a slight opalescence.

100 g

indomethacin 3 g

troxerutin 2 g

Excipients: carbomer - 2 g, disodium edetate - 0.05 g, sodium benzoate - 0.25 g, macrogol 400 - 40 g, isopropanol - 20 g, dimethyl sulfoxide - 15 g, Fresco BM&GD R.08.0932.1 flavoring - 0.2 g, purified water - up to 100 g.

• Hypersensitivity

• leukopenia,

• hemorrhagic diathesis.

pharmachologic effect

IndovazinЃ gel is a combined drug that contains indomethacin and troxerutin.

Indomethacin has a pronounced anti-inflammatory, analgesic and decongestant effect. This leads to pain relief, less swelling and a shorter recovery time for damaged tissues. The main mechanism of action is associated with the suppression of prostaglandin synthesis through reversible blockade of COX-1 and COX-2.

Troxerutin (trihydroxyethylrutinoside) is a bioflavonoid. It belongs to angioprotective agents. Reduces capillary permeability and exhibits venotonic effect. Blocks the venodilating effect of histamine, bradykinin and acetylcholine. It has an anti-inflammatory effect on the peri-venous tissue, reduces capillary fragility and has some antiplatelet effect. Reduces swelling, improves trophism in pathological changes associated with venous insufficiency.

When applied to the skin, IndovazinЃ gel suppresses the inflammatory edematous reaction, relieves pain and temperature in the foci of inflammation located on the surface and in depth, reaching the blood vessels located there. Shows venotonic and capillary-protective effect.

Pharmacokinetics

The ointment base used provides solubility and release of indomethacin and troxerutin.

The gel dosage form, which includes indomethacin and troxerutin, is well absorbed from the skin surface and provides a therapeutic effect of the drug.

When applied to the skin, concentrations close to therapeutic are created in the subcutaneous tissue and periarticular tissues. The penetration of the active components of the drug into the systemic circulation is clinically insignificant.

Side effect

The drug is usually well tolerated.

Local reactions: the appearance of symptoms of hypersensitivity from the skin is possible - contact dermatitis, itching, redness, rash, a feeling of warmth and burning at the site of application.

Application during pregnancy and lactation

There is no clinical experience proving the safety of the drug when used during pregnancy and lactation. Its use is possible only if the expected benefit outweighs the potential risk to the fetus.

Application in children

Contraindicated in children under 14 years of age.

special instructions

It is not applied to open wounds, mucous membranes, mouth, eyes.

In case of contact with eyes, mucous membranes or open wound surfaces, local irritation is observed - tearing, redness, burning, pain.

Necessary measures - rinsing the affected area with copious amounts of distilled water or saline until the complaints disappear or decrease.

IndovazinЃ gel contains sodium benzoate and propylene glycol as excipients that can irritate the skin.

Influence on the ability to drive vehicles and mechanisms

Does not affect the speed of psychomotor reactions when driving and working with mechanisms.

Overdose

There is no evidence of cases of overdose with topical application. If large amounts are accidentally swallowed, a burning sensation in the mouth, salivation, nausea, and vomiting may occur.

Treatment: washing the mouth and stomach, if necessary, symptomatic treatment.

Drug interactions

The ointment can enhance the effect of drugs that cause photosensitization.

No clinically significant interactions with other drugs have been described.