Ingaron lyophilisate for preparation of solution for intranasal administration 100 000 IU, No. 1

• Prevention and treatment (as part of complex therapy) of influenza.

• Prevention and treatment (as part of complex therapy) of influenza H5N1 and H1N1.

Intranasally. The contents of the vial are dissolved in 5 ml of water for injection. At the first signs of influenza, ARVI, 2 drops in each nasal passage after using the toilet of the nasal passages 5 times a day for 5 to 7 days. For the prevention of acute respiratory viral infections and influenza upon contact with a patient and / or hypothermia 2 - 3 drops in each nasal passage every other day 30 minutes before breakfast for 10 days. If necessary, preventive courses are repeated. With a single contact, one instillation is sufficient. After instillation, it is recommended to massage the wings of the nose with your fingers for several minutes to evenly distribute the drug in the nasal cavity.

Each bottle contains:

active substance:

Recombinant human interferon gamma - 100,000 IU

Excipient: mannitol 14.5 mg

• Individual intolerance to interferon gamma or any other component of the drug.

• Pregnancy.

• Children's age (under 7 years old).

Pharmacological properties

INGARONЃ is a recombinant human interferon gamma, consists of 144 amino acid residues (a.a.), devoid of the first three amino acid residues. about. Cys-Tyr-Cys replaced by Met. Molecular weight 16.9 kDa. Obtained by microbiological synthesis in a recombinant Escherichia coli strain and purified by column chromatography. The specific antiviral activity on cells (human fibroblasts) infected with the vesicular stomatitis virus is 2 ? 107 U per mg of protein. Interferon gamma (immune interferon) is an important anti-inflammatory cytokine produced in the human body by natural killer cells, CD4 Th1 cells and CD8 cytotoxic suppressor cells. Receptors for interferon gamma have macrophages, neutrophils, natural killer cells, cytotoxic T-lymphocytes. Activates the effector functions of these cells,in particular, their microbicidal, cytotoxicity, their production of cytokines, superoxide and nitroxide radicals (thereby causing the death of intracellular parasites). Interferon gamma blocks the replication of viral DNA and RNA, the synthesis of viral proteins and the assembly of mature viral particles. In this case, it causes a cytotoxic effect on virus-infected cells. Inhibits B-cell response to interleukin-4, inhibits IgE production and expression of CD23 antigen. It is an inducer of apoptosis of differentiated B-cells, giving rise to autoreactive clones. Cancels the suppressive effect of interleukin-4 on interleukin-2-dependent proliferation and generation of activated killer lymphokines. Activates the production of proteins of the acute phase of inflammation, enhances the expression of genes C2 and C4 components of the complement system.Unlike other interferons, it increases the expression of MHC antigens of both class I and II on different cells, and induces the expression of these molecules even on those cells that do not express them constitutively. This increases the efficiency of the presentation of antigens and the ability of their recognition by T-lymphocytes. Does interferon gamma block synthesis? ЦTGF, responsible for the development of fibrosis of the lungs and liver.

Application during pregnancy and during breastfeeding

Preclinical studies did not reveal teratogenic or fetotoxic effects, however, the safety of the drug in pregnant women and nursing mothers has not been established, and therefore, use during pregnancy and during breastfeeding is contraindicated.

Side effect

Not marked.

Interaction with other medicinal products

Pharmaceutical interaction: it is unacceptable to mix the lyophilisate or the ready-made solution for intranasal administration of Ingaron with other powders, solutions or solvents (except for water for injection) in one vial in order to avoid the loss of activity of the active substance.

The influence of the drug on the ability to drive vehicles, mechanisms

Has not been studied.