Kaltsypotryol | Dayvonex ointment 50 Ојg / g, 30 g
Special Price
$35.28
Regular Price
$43.00
In stock
SKU
BID494225
Latin name
daivonex
daivonex
Latin name
daivonex
Release form
Ointment for external use.
Pharmacological action
Pharmacodynamics
The drug for the treatment of psoriasis.
Calcipotriol is a synthetic analogue of the active metabolite of vitamin D, stimulates morphological differentiation and inhibits the proliferation of keratinocytes, which underlies its therapeutic effect in psoriasis.
Calcipotriol is a potent inhibitor of T-lymphocyte activation caused by interleukin I.
The effect of calcipotriol on calcium metabolism is 100 times weaker than vitamin D3.
Pharmacokinetics
Transdermal absorption of calcipotriol is, depending on the dose used, from 1% to 5%. Calcipotriol undergoes rapid biotransformation in the liver with the formation of pharmacologically inactive metabolites. T 1/2 is very short.
Indications
Psoriasis vulgar, incl. chronic psoriasis of the scalp.
Contraindications
Hypersensitivity to the components of the drug.
Diseases accompanied by impaired calcium metabolism.
With caution, the drug should be used for: hypercalcemia, hypercalciuria, hypervitaminosis D, nephrolithiasis. In children due to lack of experience. In patients older than 65 years.
Use during pregnancy and lactation
The safety of the drug during pregnancy and lactation has not been established.
It is not known whether calcipotriol with breast milk is excreted.
Composition
1 g of ointment for external use contains:
Active ingredient: calcipotriol 50 mcg.
Excipients: disodium edetate, sodium hydrogen phosphate,? -tocopherol, liquid paraffin, polyethylene glycol stearate, propylene glycol, white paraffin, water.
Dosage and administration
Ointment is applied in a thin layer to the affected skin 2 times / day. The therapeutic effect is usually observed after 1-2 weeks from the start of treatment. The duration of the course of treatment is no more than 6-8 weeks.
For adults: the maximum daily dose is 15 g, the maximum dose per week is not more than 100 g.
For children over the age of 12 years: the maximum dose per week is 75 g.
For children aged 6 to 12 years: the maximum dose per week - no more than 50 g.
Side effects
Dermatological reactions: possible - local skin irritation, erythema and skin itching rarely - dermatitis, exacerbation of psoriasis in some cases - hyperpigmentation, photosensitivity.
From the side of metabolism: hypercalciuria, hypercalcemia.
Drug interaction
Divexone should not be used concomitantly with topical preparations containing salicylic acid.
overdose
Symptoms: Increased calcium levels in the blood may occur when using the drug at doses exceeding the recommended dose.
Treatment: Withdrawal.
Storage conditions
Store at a temperature not exceeding 25 РC.
Keep out of the reach of children.
Expiration
2 years.
Deystvuyuschee substances
Kaltsypotryol
dosage form
dosage form
ointment
daivonex
Release form
Ointment for external use.
Pharmacological action
Pharmacodynamics
The drug for the treatment of psoriasis.
Calcipotriol is a synthetic analogue of the active metabolite of vitamin D, stimulates morphological differentiation and inhibits the proliferation of keratinocytes, which underlies its therapeutic effect in psoriasis.
Calcipotriol is a potent inhibitor of T-lymphocyte activation caused by interleukin I.
The effect of calcipotriol on calcium metabolism is 100 times weaker than vitamin D3.
Pharmacokinetics
Transdermal absorption of calcipotriol is, depending on the dose used, from 1% to 5%. Calcipotriol undergoes rapid biotransformation in the liver with the formation of pharmacologically inactive metabolites. T 1/2 is very short.
Indications
Psoriasis vulgar, incl. chronic psoriasis of the scalp.
Contraindications
Hypersensitivity to the components of the drug.
Diseases accompanied by impaired calcium metabolism.
With caution, the drug should be used for: hypercalcemia, hypercalciuria, hypervitaminosis D, nephrolithiasis. In children due to lack of experience. In patients older than 65 years.
Use during pregnancy and lactation
The safety of the drug during pregnancy and lactation has not been established.
It is not known whether calcipotriol with breast milk is excreted.
Composition
1 g of ointment for external use contains:
Active ingredient: calcipotriol 50 mcg.
Excipients: disodium edetate, sodium hydrogen phosphate,? -tocopherol, liquid paraffin, polyethylene glycol stearate, propylene glycol, white paraffin, water.
Dosage and administration
Ointment is applied in a thin layer to the affected skin 2 times / day. The therapeutic effect is usually observed after 1-2 weeks from the start of treatment. The duration of the course of treatment is no more than 6-8 weeks.
For adults: the maximum daily dose is 15 g, the maximum dose per week is not more than 100 g.
For children over the age of 12 years: the maximum dose per week is 75 g.
For children aged 6 to 12 years: the maximum dose per week - no more than 50 g.
Side effects
Dermatological reactions: possible - local skin irritation, erythema and skin itching rarely - dermatitis, exacerbation of psoriasis in some cases - hyperpigmentation, photosensitivity.
From the side of metabolism: hypercalciuria, hypercalcemia.
Drug interaction
Divexone should not be used concomitantly with topical preparations containing salicylic acid.
overdose
Symptoms: Increased calcium levels in the blood may occur when using the drug at doses exceeding the recommended dose.
Treatment: Withdrawal.
Storage conditions
Store at a temperature not exceeding 25 РC.
Keep out of the reach of children.
Expiration
2 years.
Deystvuyuschee substances
Kaltsypotryol
dosage form
dosage form
ointment
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