Kofitsil-plus tablets, No. 10

Kofitsil-plus tablets, No. 10; 'Kofitsil-plus is used in adults with moderate or mild pain syndrome (headache, toothache, neuralgia, myalgia, chest radicular syndrome, lumbago, arthralgia, algomenorrhea, migraine), in adults and children over 15 years of age to reduce elevated body temperature, with 'colds' and other infectious and inflammatory diseases.

The drug is taken orally after meals, 1-2 tablets 2-3 times a day.

The maximum daily dose is 6 tablets. The break between doses of the drug should be at least 4 hours.

To reduce the irritating effect on the gastrointestinal tract, the drug should be taken after meals with water, milk, alkaline mineral water.

In case of impaired renal or liver function, the interval between doses is at least 6 hours.

The drug should not be taken for more than 5 days when prescribed as an anesthetic and more than 3 days as an antipyretic.

Other dosages and dosage regimens are determined by the doctor

Composition for one tablet

Active ingredients: acetylsalicylic acid - 300.0 mg, paracetamol - 100.0 mg, caffeine (anhydrous caffeine) - 50.0 mg.

Excipients: potato starch - 97.88 mg, sodium carboxymethyl starch (Type A) - 30.00 mg, talc - 11.20 mg, stearic acid - 5.60 mg, povidone (polyvinylpyrrolidone, Povidone K-17) - 4, 00 mg, calcium stearate - 1.32 mg.

- hypersensitivity to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (NSAIDs) or xanthines; hypersensitivity to other components of the drug;

- erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase), gastrointestinal bleeding;

- severe violations of liver or kidney function;

- asthma induced by the intake of acetylsalicylic acid, salicylates and other non-steroidal anti-inflammatory drugs;

- hemorrhagic diathesis (von Willebrand disease, hemophilia, telangiectasia, hypoprothrombinemia, thrombocytopenia, thrombocytopenic purpura);

- exfoliating aortic aneurysm;

- deficiency of glucose-b-phosphate dehydrogenase;

- portal hypertension, vitamin K deficiency;

- hyperexcitability, sleep disturbance, anxiety disorders (agoraphobia, panic disorder);

- organic diseases of the cardiovascular system (acute myocardial infarction, severe ischemic heart disease, arterial hypertension), paroxysmal tachycardia, frequent ventricular premature beats;

- glaucoma;

- surgical interventions accompanied by bleeding;

- children under 15 years old.

Application during pregnancy and during breastfeeding

It is contraindicated to use during pregnancy in the I and III trimester, in the second trimester of pregnancy, a single dose of the drug in recommended doses is possible only if the expected benefit to the mother outweighs the potential risk to the fetus. If necessary, the use of the drug during lactation should stop breastfeeding.

With care - hyperuricemia, urate nephrolithiasis, gout, gastric ulcer and / or duodenal ulcer (in history), severe heart failure.

Pharmacodynamics

Kofitsil-plus is a combined drug, the action of which is determined by the components that make up it. Acetylsalicylic acid has an analgesic, antipyretic, anti-inflammatory effect associated with the suppression of cyclooxygenases 1 and 2, which regulate the synthesis of prostaglandins; inhibits platelet aggregation, Caffeine increases the reflex excitability of the spinal cord, excites the respiratory and vasomotor centers, dilates the blood vessels of skeletal muscles, brain, heart, kidneys, reduces platelet aggregation; reduces drowsiness, fatigue, increases mental and physical performance. Paracetamol has antipyretic, analgesic effects.

Side effects

Anorexia, nausea, vomiting, gastralgia, diarrhea, erosive and ulcerative lesions of the gastrointestinal tract, gastrointestinal bleeding, hepatic and / or renal failure, increased blood pressure, tachycardia. Allergic reactions: skin rash, Quincke's edema, bronchospasm. With prolonged use - dizziness, headache, visual disturbances, tinnitus, decreased platelet aggregation, hypocoagulation, hemorrhagic syndrome (epistaxis, bleeding gums, purpura, etc.), kidney damage with papillary necrosis; deafness; Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), Reye's syndrome in children (metabolic acidosis, disorders of the nervous system and psyche, vomiting, liver dysfunction).

Overdose

Nausea, vomiting, stomach pain, sweating, pallor of the skin, tachycardia. With mild intoxication - ringing in the ears; severe intoxication - drowsiness, collapse, convulsions, bronchospasm, shortness of breath, anuria, bleeding, As intoxication intensifies, progressive respiratory paralysis and uncoupling of oxidative phosphorylation, causing respiratory acidosis. If you suspect poisoning, you should immediately seek medical help. Treatment: the victim should undergo gastric lavage and prescribe adsorbents (activated carbon).

Drug interactions

Enhances the effect of heparin, indirect anticoagulants, reserpine, steroid hormones and hypoglycemic agents. Reduces the effectiveness of spironolactone, furosemide, antihypertensive drugs, anti-gout drugs that promote the excretion of uric acid. It enhances the side effects of glucocorticosteroids, sulfonylurea derivatives, methotrexate, non-narcotic analgesics and non-steroidal anti-inflammatory drugs. Avoid the combination of the drug with barbiturates, antiepileptic drugs, zidovudine, rifampicin and alcoholic beverages (increases the risk of hepatotoxic effect). Under the influence of paracetamol, the elimination time of chloramphenicol increases by 5 times. Caffeine accelerates the absorption of ergotamine. Salicylamide, etc.stimulants of microsomal oxidation contribute to the formation of toxic metabolites of paracetamol, which affect liver function. Metoclopramide accelerates the absorption of paracetamol, with repeated administration of paracetamol can enhance the effect of anticoagulants (dicoumarin derivatives).

special instructions

With prolonged use of the drug, it is necessary to monitor the peripheral blood and the functional state of the liver. Since acetylsalicylic acid has an antiaggregate effect, the patient, if he is to undergo surgery, must warn the doctor in advance about taking the drug. Acetylsalicylic acid in low doses reduces the excretion of uric acid. This can in some cases provoke a gout attack. During treatment, you should stop drinking alcoholic beverages (increased risk of gastrointestinal bleeding). Acetylsalicylic acid has a teratogenic effect: when used in the first trimester of pregnancy, it leads to a malformation - splitting of the upper palate; in the third trimester, it helps to inhibit labor (inhibition of prostaglandin synthesis),closure of the ductus arteriosus in the fetus, which causes hyperplasia of the pulmonary vessels and hypertension in the vessels of the pulmonary circulation. Acetylsalicylic acid is excreted in breast milk, which increases the risk of bleeding in a child due to dysfunction of platelets. The drug is not prescribed as an anesthetic for persons under 18 years of age, as an antipyretic agent for children under 15 years of age with acute respiratory diseases caused by viral infections due to the risk of Reye's syndrome (encephalopathy and acute fatty liver disease with acute development of liver failure).which increases the risk of bleeding in a child due to dysfunction of platelets. The drug is not prescribed as an anesthetic for persons under 18 years of age, as an antipyretic agent for children under 15 years of age with acute respiratory diseases caused by viral infections due to the risk of Reye's syndrome (encephalopathy and acute fatty liver disease with acute development of liver failure).which increases the risk of bleeding in a child due to dysfunction of platelets. The drug is not prescribed as an anesthetic for persons under 18 years of age, as an antipyretic agent for children under 15 years of age with acute respiratory diseases caused by viral infections due to the risk of Reye's syndrome (encephalopathy and acute fatty liver disease with acute development of liver failure).

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