Legalon capsules 70mg, No. 30

• Toxic liver damage (alcoholism; intoxication with halogenated hydrocarbons, heavy metal compounds; medicinal liver damage) and their prevention.

Inside, after meals, with a little water.

2 capsules 3 times a day.

Maintenance dose - 1 capsule 3 times a day.

One capsule contains:

Active ingredient: milk thistle fruit extract dry (36-44: 1) - 86.5-93.35 mg, equivalent to 70 mg of silymarin (DNPH), equivalent to 54.1 mg of silymarin (HPLC / DF) calculated on silibinin.

Excipients: polysorbate 80, povidone, mannitol, sodium carboxymethyl starch (type A), magnesium stearate.

Shell: hard gelatin capsule, size '2', which includes: gelatin, iron dye red oxide (E172), titanium dioxide (E171), sodium lauryl sulfate, iron dye black oxide (E172).

• Hypersensitivity to the components of the drug.

APPLICATION DURING PREGNANCY AND BREASTFEEDING

It is not recommended to use the drug during pregnancy and breastfeeding.

Trade name: Legalon Ѓ 70

International non-proprietary name:

Milk thistle fruit extract

Dosage form:

capsules.

Composition:

One capsule contains:

Active ingredient: milk thistle fruit extract dry (36-44: 1) - 86.5-93.35 mg, equivalent to 70 mg of silymarin (DNPH), equivalent to 54.1 mg of silymarin (HPLC / DF) calculated on silibinin.

Excipients: polysorbate 80, povidone, mannitol, sodium carboxymethyl starch (type A), magnesium stearate.

Shell: hard gelatin capsule, size '2', which includes: gelatin, iron dye red oxide (E172), titanium dioxide (E171), sodium lauryl sulfate, iron dye black oxide (E172).

Description:

Capsule appearance: hard gelatin capsules, size '2', brown body and cap. Appearance of the capsule contents: yellow powder.

Pharmacotherapeutic group:

hepatoprotective agent.

PHARMACOLOGICAL PROPERTIES

It interacts with free radicals in the liver and converts them into less toxic compounds, interrupting the process of lipid peroxidation, and prevents the destruction of cellular structures. In damaged hepatocytes, it stimulates the synthesis of structural and functional proteins and phospholipids (due to specific stimulation of RNA polymerase A), stabilizes cell membranes, prevents the loss of cell components (transaminases), and accelerates the regeneration of liver cells. It inhibits the penetration of some hepatotoxic substances into the cell.

Pharmacokinetics .

Absorption - low and slow (half-absorption period - 2.2 hours), metabolized in the liver by conjugation, half-life - 6 hours. It is excreted mainly in the bile in the form of glucuronides and sulfates. Does not accumulate in the body. Intestinal-hepatic circulation is noted.

INDICATIONS FOR USE

• Toxic liver damage (alcoholism; intoxication with halogenated hydrocarbons, heavy metal compounds; medicinal liver damage) and their prevention.

CONTRAINDICATIONS

• Hypersensitivity to the components of the drug.

APPLICATION DURING PREGNANCY AND BREASTFEEDING

It is not recommended to use the drug during pregnancy and breastfeeding.

INTERACTION WITH OTHER DRUGS

Not described.

DOSAGE AND APPLICATION

Inside, after meals, with a little water. 2 capsules 3 times a day. Maintenance dose - 1 capsule 3 times a day.

SIDE EFFECT

Allergic reactions, rarely - a laxative effect.

RELEASE FORM

Capsules 70 mg. 10 capsules in a blister made of PVC-aluminum foil. 2, 3 or 6 blisters in a cardboard box along with instructions for use.

STORAGE CONDITIONS

In sheltered from light, at a temperature not higher than 30 ? C. Keep out of the reach of children.

SHELF LIFE

5 years.

Do not use after the expiration date printed on the package.

TERMS OF RELEASE FROM PHARMACIES

Without recipe.