Lopedium tablets 2mg, No. 10

• Symptomatic treatment of acute and chronic diarrhea of ??various origins (allergic, emotional, medicinal, radiation; with a change in diet and quality composition of food, with metabolic and absorption disorders; as an adjunct for infectious diarrhea).

• Stool regulation in patients with ileostomy.

Inside, tablets and capsules should be swallowed without chewing with 100 ml of water.

Adults with acute and chronic diarrhea are initially prescribed 4 mg, then 2 mg after each act of defecation in the case of loose stools.

The maximum daily dose is 16 mg.

Children over 6 years of age are prescribed 2 mg after each act of defecation in the case of loose stools.

The maximum daily dose is 6 mg.

After stool normalization or in the absence of stool for more than 12 hours, treatment should be discontinued.

1 tablet or capsule contains

Active ingredient: loperamide hydrochloride - 2 mg

Excipients:

Tablets: lactose monohydrate, calcium hydrogen phosphate dihydrate, corn starch, sodium starch glycolate, colloidal silicon dioxide, magnesium stearate.

Capsules: lactose monohydrate, corn starch, talc, magnesium stearate

• Hypersensitivity to the drug,

• diverticulosis,

• intestinal obstruction,

• ulcerative colitis in the acute stage,

• diarrhea against the background of acute pseudomembranous enterocolitis;

• in the form of monotherapy - dysentery and other infections of the gastrointestinal tract;

• pregnancy (I trimester), lactation period.

• Loperamide in capsules and tablets is not prescribed for children under 6 years of age.

With caution - liver failure.

Trade name: Lopedium

International non-proprietary name:

Loperamide

Chemical name: 4- [4- (4-chlorophenyl) -4-hydroxypyridin-1-yl] -N, N-dimethyl-2,2-diphenylbutanamide hydrochloride

Dosage forms: tablets, capsules

Composition

1 tablet or capsule contains

Active ingredient: loperamide hydrochloride - 2 mg

Excipients:

Tablets: lactose monohydrate, calcium hydrogen phosphate dihydrate, corn starch, sodium starch glycolate, colloidal silicon dioxide, magnesium stearate.

Capsules: lactose monohydrate, corn starch, talc, magnesium stearate

Description

White or almost white round tablets, convex on one side, on the other side of the risk, the surface of the tablet is sloped towards the risk.
Hard gelatin capsules filled with white homogeneous powder. The lower part of the capsules is gray, the upper part is dark green.

Pharmacotherapeutic group:

antidiarrheal agent.

Pharmacological properties

By binding to the opioid receptors of the intestinal wall, it reduces the tone and motility of intestinal smooth muscles. Slows down peristalsis and increases the transit time of intestinal contents. Increases the tone of the anal sphincter. Promotes the retention of feces and the reduction of the urge to defecate. The action occurs quickly and lasts 4-6 hours.

Pharmacokinetics
Absorption - 40%. The time to reach maximum concentration is 2.5 hours. Communication with plasma proteins - 97%. The half-life is 9-14 hours. Does not penetrate the blood-brain barrier. Almost completely metabolized in the liver by conjugation. It is excreted mainly in the bile and kidneys.

Indications for use

• Symptomatic treatment of acute and chronic diarrhea of ??various origins (allergic, emotional, medicinal, radiation; with a change in diet and quality composition of food, with metabolic and absorption disorders; as an adjunct for infectious diarrhea).

• Stool regulation in patients with ileostomy.

Contraindications

• Hypersensitivity to the drug,

• diverticulosis,

• intestinal obstruction,

• ulcerative colitis in the acute stage,

• diarrhea against the background of acute pseudomembranous enterocolitis;

• in the form of monotherapy - dysentery and other infections of the gastrointestinal tract;

• pregnancy (I trimester), lactation period.

• Loperamide in capsules and tablets is not prescribed for children under 6 years of age.

With caution - liver failure.

Method of administration and dosage

Inside, tablets and capsules should be swallowed without chewing with 100 ml of water.

Adults with acute and chronic diarrhea are initially prescribed 4 mg, then 2 mg after each act of defecation in the case of loose stools.

The maximum daily dose is 16 mg.

Children over 6 years of age are prescribed 2 mg after each act of defecation in the case of loose stools.

The maximum daily dose is 6 mg.

After stool normalization or in the absence of stool for more than 12 hours, treatment should be discontinued.

Side effect

Headache; gastralgia, dry mouth, allergic reactions (skin rash), drowsiness or insomnia, dizziness, intestinal colic, nausea, vomiting, constipation.

It is extremely rare - intestinal obstruction.

Overdose

Symptoms: depression of the central nervous system (stupor, impaired coordination, drowsiness, miosis, muscle hypertonia, respiratory depression), intestinal obstruction.

Treatment: antidote - naloxone; given that the duration of action of loperamide is longer than that of naloxone, it is possible to re-administer the latter.

Symptomatic treatment: activated carbon, gastric lavage, artificial ventilation.

Medical supervision is necessary for at least 48 hours.

special instructions

If there is no effect after 2 days of using Lopedium, it is necessary to clarify the diagnosis and exclude the infectious genesis of diarrhea.

If constipation or bloating develops during treatment, the drug should be discontinued.

In patients with impaired liver function, careful monitoring of signs of toxic damage to the central nervous system is necessary.

During treatment, it is necessary to replenish the loss of fluid and electrolytes.

In case of drowsiness or dizziness, you should refrain from driving and operating machinery.

Each tablet or capsule corresponds to 0.01 bread. units

Interaction with other drugs

Clinically significant interactions of loperamide with other drugs have not been established.

Release form

10 tablets or capsules in blisters (PVC / aluminum or PP / aluminum).
1, 2, 3 or 5 blisters with instructions for use in a cardboard box.

Storage conditions

At a temperature not exceeding 25 ? C, out of the reach of children.

Shelf life

5 years. Do not use the medicinal product after the expiration date indicated on the package.

Terms of dispensing from pharmacies: Without prescription.