Meditin 1% 10ml

DESCRIPTION

Meditin 1% is a medicinal preparation for sedation and analgesia of sport horses. Dosage form: injection solution. In appearance, the drug is a colorless transparent liquid.

COMPOSITION

Meditin 1% for sports horses contains 10.0 mg of medetomidine hydrochloride as an active ingredient in 1 ml, as well as auxiliary substances: sodium chloride - 9.0 mg, benzyl alcohol - 9.0 mg and water for injection up to 1 ml.

PHARMACOLOGICAL PROPERTIES

Meditin belongs to the group of ОІ 2-agonists. Medetomidine, the active ingredient of Meditin, belongs to stimulants of ОІ2-adrenergic receptors, the mechanism of action of which is to inhibit the transmission of nerve impulses due to competition with norepinephrine. It causes depression of the central nervous system and an increase in the pain threshold. The action of medetomidine is dose dependent: small doses have moderate sedation without analgesia, while large doses cause significant sedation and analgesia. The drug has a faster effect when administered intravenously, slower - when administered intramuscularly and subcutaneously. After intramuscular administration, the maximum concentration of medetomidine in the blood is reached after 15-30 minutes. Medetomidine is rapidly distributed in the body. Serum protein binding is 85-90%. Medetomidine is oxidized in the liver, a small part is methylated in the kidneys. Most of the drug's metabolites are excreted in the urine. The half-life is 1-2 hours.

Meditin, according to the degree of impact on the body, belongs to moderately hazardous substances (hazard class 3 according to GOST 12.1.007), in recommended doses it is well tolerated by animals, does not have embryotoxic, teratogenic and hepatotoxic properties.

INDICATIONS

Meditin is administered to sports horses for sedation and analgesia during surgical operations and various clinical trials; it is recommended to use the drug before injection and / or inhalation anesthesia.

APPLICATION

Meditin is administered parenterally: for sport horses - intravenously.

If necessary, the drug can be re-administered 10-15 minutes after the first injection. To achieve sedative and analgesic effects in horses, Meditin 1% is used at a dose of 0.2-1.2 ml / 100 kg. Doses of the drug vary depending on the desired effect, individual characteristics and breed of animal. For horses, the drug is administered intravenously slowly (1 ml per minute). It is recommended to use 2 sterile needles: one for filling the syringe from the vial, the other directly for injection. As soon as the required dose of the drug is drawn into the syringe, it should be disconnected from the needle in the vial. An injection needle is inserted into the animal, and only then the syringe with the drug is connected to it.

Kind of animal Dose of medetomidine, mcg / kg The amount of the drug Effect

Sport horses (Meditin 1%) 20-40 0.2 - 0.4 ml / 100kg Weak sedation

40-80 0.4 - 0.8 ml / 100kg Moderate sedation

80-120 0.8 - 1.2 ml / 100kg Deep sedation

Meditin has a moderate anesthetic effect, so it is necessary to adjust the doses of anesthetics administered to animals that were previously injected with Meditin.

Meditin can be administered in combination with ketamine or butorphanol. Meditin should not be used in conjunction with sympathomimetic amines, or with a combination of sulfonamides with trimethoprim. With the parallel use of drugs that cause depression of the central nervous system, it is possible to potentiate the inhibitory effect of Meditin, in which case the dosage should be adjusted.

CONTRAINDICATIONS

Meditin is not intended for use in productive animals.

The drug is not used for pregnant and lactating animals, as well as those in a state of shock, exhausted or weakened. It is forbidden to use the drug for animals with increased individual sensitivity to the components of the drug, as well as for animals with severe cardiovascular diseases or diseases of the respiratory system, with impaired liver or kidney function, damage to the gastrointestinal tract (volvulus of the stomach, entrapment of organs, obstruction of the esophagus), sugar diabetes, with an increase in intraocular pressure.

OVERDOSE

In case of an overdose in an animal, apnea, bradycardia, a drop in blood pressure are possible. In case of an overdose or in cases where the effect of the administered medetomidine poses a threat to the patient's life, an appropriate dose of atipamezole is used if the removal of the sedative and analgesic effect of Meditin is not dangerous for the operated animal. If it is necessary to eliminate bradycardia, while maintaining a sedative effect, it is advisable to use atropine.

SIDE EFFECTS

Feeding should be discontinued 12 hours before anesthesia. Animals should be kept warm during and after anesthesia.

In some animals, bradypnea is observed (4 - 6 respiratory movements per minute), the number of heartbeats decreases by about 50% compared to the norm, a decrease in body temperature is possible, which is explained by the mechanism of action of the drug. In rare cases, it is possible to develop bradycardia with atriventricular block (1-2 degrees), extrasystoles, coronospasm and a decrease in cardiac output. Blood pressure rises slightly at first, then returns to normal, or slightly lower. In rare cases, muscle tremors and uncontrolled urination may occur. If the operation is delayed, it is necessary to regularly moisten the cornea to prevent it from drying out. In rare cases, hyperglycemia may develop due to suppression of insulin secretion.

Horses, after the introduction of Meditin, may experience rapidly passing arrhythmias, impaired coordination, and increased sweating. Sometimes there is a slight tremor of individual muscles or muscle groups and uncontrolled urination. Blood pressure rises slightly at first, then returns to normal, or slightly lower.

SPECIAL INSTRUCTIONS

Unused medicinal product is disposed of in accordance with legal requirements.

Empty vials from under the medicinal product must not be used for domestic purposes, they must be disposed of with household waste.

PRECAUTIONS

When working with Meditin, you should follow the general rules of personal hygiene and safety measures provided for when working with medicines. At the end of work, hands should be washed with warm water and soap.

People with hypersensitivity to the drug components should avoid direct contact with Meditin.

FIRST AID MEASURES

In case of accidental contact of the drug with the skin or mucous membranes of the eyes, they should be immediately rinsed with plenty of water. In case of allergic reactions or accidental ingestion of the drug into the human body, you should immediately contact a medical institution (you should have instructions for the use of the drug or a label with you). In this case, you cannot drive a car, since sedation and changes in blood pressure may develop.

SHELF LIFE AND STORAGE

Store the drug in the manufacturer's closed packaging, separately from food and feed, in a dry place protected from direct sunlight at a temperature of 5 В° C to 25 В° C. The shelf life, subject to storage conditions in a sealed package, is 2 years from the date of production, after opening the bottle - no more than 30 days. It is forbidden to use Meditin after the expiration date.

PACKAGING

The drug is produced in 10 ml packs in dark glass vials sealed with rubber stoppers with aluminum caps.

Specifications

KolVUP

five

Manufacturer

APICENNA

Temperature regime

from +5 to +25

Teaser

for sedation and analgesia of sport horses