metronidazole | Trichopol tablets 250 mg, 20 pcs.
Special Price
$14.70
Regular Price
$22.00
In stock
SKU
BID494441
Latin name
Trichopol
Trichopol
Latin name
Trichopol
Release form
White tablets with a yellowish tint, round biconvex, have a dividing risk. The tablets turn yellow when exposed to light.
packaging 10 pcs - blisters (2) - packs of cardboard.
Pharmacological action
Antiprotozoal drug with antibacterial activity, derivative of 5-nitroimidazole. The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of the cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of microorganisms.
Metronidazole is active against Trichomonas vaginalis, Entamoeba histolytica, Gardnerella vaginalis, Giardia intestinalis, Lamblia spp. and obligate anaerobes Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens) of certain gram-positive microorganisms (Eubacterium spp., Clostridium spp., Peptococcus spp., Peptostreptococcus spp.). The MIC for these strains is 0.125-6.25 μg / ml.
In combination with amoxicillin, it is active against Helicobacter pylori (amoxicillin inhibits the development of resistance to metronidazole).
Metronidazole has no bactericidal effect against most bacteria and facultative anaerobes, fungi and viruses. In the presence of mixed flora (aerobes and anaerobes), metronidazole is synergistic with antibiotics effective against conventional aerobes.
Metronidazole increases the sensitivity of tumors to radiation, causes sensitization to ethanol (disulfiram-like effect), and stimulates reparative processes.
Contraindications
leukopenia (including history)
organic damage to the central nervous system (including epilepsy)
liver failure (if the drug is prescribed in high doses)
I trimester of pregnancy
lactation (breastfeeding)
children under 3 years of age
hypersensitivity to metron other derivatives of nitroimidazole, as well as any other components of the drug.
With caution, the drug should be prescribed to patients with renal and / or liver failure in the II and III trimesters of pregnancy.
Use during pregnancy and lactation
Trichopolum is contraindicated for use in the first trimester of pregnancy. The use of the drug in the II and III trimesters is possible only in those cases when the intended benefit to the mother outweighs the potential risk to the fetus.
If it is necessary to use Trichopolum during lactation, breast-feeding should be discontinued.
Composition
1 tab.
metronidazole 250 mg
Excipients: potato starch, gelatin, starch syrup, magnesium stearate.
Side effects of the
Digestive system: epigastric pain, nausea, vomiting, diarrhea, constipation, intestinal colic, loss of appetite, anorexia, taste disturbance, unpleasant metallic taste in the mouth, dry mouth, glossitis, stomatitis is very rare - abnormal liver function tests, cholestatic hepatitis, jaundice, pancreatitis.
From the side of the central nervous system: with prolonged use - headache, dizziness, impaired coordination of movements, ataxia, peripheral neuropathy, increased irritability, irritability, depression, sleep disturbance, drowsiness, weakness in some cases - confusion, hallucinations, convulsions very rarely - encephalopathy .
From the urinary system: dysuria, cystitis, polyuria, urinary incontinence, urine staining in red-brown color.
From the reproductive system: vaginal pain.
Allergic reactions: skin rash, itching, urticaria, erythema multiforme exudative, nasal congestion, fever.
From the musculoskeletal system: myalgia, arthralgia.
From the hemopoietic system: rarely leukopenia - agranulocytosis, neutropenia, thrombocytopenia, pancytopenia.
Other: flattening of a tooth of T on an ECG is extremely rare - ototoxicity abscess rash.
Drug Interaction
Metronidazole enhances the action of warfarin and other coumarin anticoagulants (this combination requires a reduction in the doses of both drugs).
Similar to disulfiram, metronidazole causes ethanol intolerance. Concomitant use of Trichopol with disulfiram can lead to the development of various neurological symptoms (the interval between the use of these drugs should be at least 2 weeks).
Cimetidine inhibits the metabolism of metronidazole, which may lead to increased plasma concentrations and increased risk of adverse reactions.
Simultaneous administration of drugs that stimulate the activity of microsomal enzymes of the liver (phenobarbital, phenytoin), can accelerate the elimination of metronidazole, which leads to a decrease in its concentration in blood plasma.
In patients receiving long-term treatment with high-dose lithium drugs, metronidazole may increase blood plasma lithium concentrations and develop intoxication symptoms.
It is not recommended to combine metronidazole with non-depolarizing muscle relaxants (vecuronium bromide).
When combined with metronidazole and cyclosporine, an increase in cyclosporine plasma concentrations may be observed.
Metronidazole decreases the fluoruracil clearance, which may increase the latter's toxicity.
Sulfanylamides enhance the antimicrobial action of metronidazole.
overdose
Symptoms: increased side effects, mainly nausea, vomiting and dizziness in more severe cases, ataxia, paraesthesia and convulsions are possible. The lethal dose for humans is unknown.
Treatment: carrying out symptomatic and supportive therapy. There is no specific antidote.
Storage conditions
The drug should be stored in a dry, dark place and out of the reach of children, at a temperature not exceeding 25 РC.
Expiration
5 years.
Deystvuyuschee substances
metronidazole
Pharmacy leave
pharmacy terms for prescription
dosage form
dosage form
tablets
Polpharma, Poland
Trichopol
Release form
White tablets with a yellowish tint, round biconvex, have a dividing risk. The tablets turn yellow when exposed to light.
packaging 10 pcs - blisters (2) - packs of cardboard.
Pharmacological action
Antiprotozoal drug with antibacterial activity, derivative of 5-nitroimidazole. The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of the cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of microorganisms.
Metronidazole is active against Trichomonas vaginalis, Entamoeba histolytica, Gardnerella vaginalis, Giardia intestinalis, Lamblia spp. and obligate anaerobes Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens) of certain gram-positive microorganisms (Eubacterium spp., Clostridium spp., Peptococcus spp., Peptostreptococcus spp.). The MIC for these strains is 0.125-6.25 μg / ml.
In combination with amoxicillin, it is active against Helicobacter pylori (amoxicillin inhibits the development of resistance to metronidazole).
Metronidazole has no bactericidal effect against most bacteria and facultative anaerobes, fungi and viruses. In the presence of mixed flora (aerobes and anaerobes), metronidazole is synergistic with antibiotics effective against conventional aerobes.
Metronidazole increases the sensitivity of tumors to radiation, causes sensitization to ethanol (disulfiram-like effect), and stimulates reparative processes.
Contraindications
leukopenia (including history)
organic damage to the central nervous system (including epilepsy)
liver failure (if the drug is prescribed in high doses)
I trimester of pregnancy
lactation (breastfeeding)
children under 3 years of age
hypersensitivity to metron other derivatives of nitroimidazole, as well as any other components of the drug.
With caution, the drug should be prescribed to patients with renal and / or liver failure in the II and III trimesters of pregnancy.
Use during pregnancy and lactation
Trichopolum is contraindicated for use in the first trimester of pregnancy. The use of the drug in the II and III trimesters is possible only in those cases when the intended benefit to the mother outweighs the potential risk to the fetus.
If it is necessary to use Trichopolum during lactation, breast-feeding should be discontinued.
Composition
1 tab.
metronidazole 250 mg
Excipients: potato starch, gelatin, starch syrup, magnesium stearate.
Side effects of the
Digestive system: epigastric pain, nausea, vomiting, diarrhea, constipation, intestinal colic, loss of appetite, anorexia, taste disturbance, unpleasant metallic taste in the mouth, dry mouth, glossitis, stomatitis is very rare - abnormal liver function tests, cholestatic hepatitis, jaundice, pancreatitis.
From the side of the central nervous system: with prolonged use - headache, dizziness, impaired coordination of movements, ataxia, peripheral neuropathy, increased irritability, irritability, depression, sleep disturbance, drowsiness, weakness in some cases - confusion, hallucinations, convulsions very rarely - encephalopathy .
From the urinary system: dysuria, cystitis, polyuria, urinary incontinence, urine staining in red-brown color.
From the reproductive system: vaginal pain.
Allergic reactions: skin rash, itching, urticaria, erythema multiforme exudative, nasal congestion, fever.
From the musculoskeletal system: myalgia, arthralgia.
From the hemopoietic system: rarely leukopenia - agranulocytosis, neutropenia, thrombocytopenia, pancytopenia.
Other: flattening of a tooth of T on an ECG is extremely rare - ototoxicity abscess rash.
Drug Interaction
Metronidazole enhances the action of warfarin and other coumarin anticoagulants (this combination requires a reduction in the doses of both drugs).
Similar to disulfiram, metronidazole causes ethanol intolerance. Concomitant use of Trichopol with disulfiram can lead to the development of various neurological symptoms (the interval between the use of these drugs should be at least 2 weeks).
Cimetidine inhibits the metabolism of metronidazole, which may lead to increased plasma concentrations and increased risk of adverse reactions.
Simultaneous administration of drugs that stimulate the activity of microsomal enzymes of the liver (phenobarbital, phenytoin), can accelerate the elimination of metronidazole, which leads to a decrease in its concentration in blood plasma.
In patients receiving long-term treatment with high-dose lithium drugs, metronidazole may increase blood plasma lithium concentrations and develop intoxication symptoms.
It is not recommended to combine metronidazole with non-depolarizing muscle relaxants (vecuronium bromide).
When combined with metronidazole and cyclosporine, an increase in cyclosporine plasma concentrations may be observed.
Metronidazole decreases the fluoruracil clearance, which may increase the latter's toxicity.
Sulfanylamides enhance the antimicrobial action of metronidazole.
overdose
Symptoms: increased side effects, mainly nausea, vomiting and dizziness in more severe cases, ataxia, paraesthesia and convulsions are possible. The lethal dose for humans is unknown.
Treatment: carrying out symptomatic and supportive therapy. There is no specific antidote.
Storage conditions
The drug should be stored in a dry, dark place and out of the reach of children, at a temperature not exceeding 25 РC.
Expiration
5 years.
Deystvuyuschee substances
metronidazole
Pharmacy leave
pharmacy terms for prescription
dosage form
dosage form
tablets
Polpharma, Poland
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