Neovir solution for injection. 250mg / 2ml, # 5

As an immunostimulating agent in combination therapy:

• prevention and treatment of influenza and other acute respiratory diseases (including against the background of immunodeficiency states);

• infections caused by the Herpes simplex virus type 1 and 2 and the Varicella zoster virus (including in persons with impaired immune system);

• cytomegalovirus infection in immunocompromised individuals;

• radiation immunodeficiency;

• treatment of HIV infection;

• encephalitis and encephalomyelitis of viral etiology;

• acute and chronic hepatitis B and C;

• urethritis, epididymitis, prostatitis, cervicitis and salpingitis of chlamydial etiology;

• lymphogranuloma venereum;

• oncological diseases;

• multiple sclerosis;

• candidiasis of the skin and mucous membranes.

The solution for injection is administered intramuscularly, a single dose is 250 mg (1 amp.) Or 4-6 mg / kg of body weight. If necessary, a single dose of Neovir can be increased to 500 mg.

The course of treatment, if there are no special indications, consists of 5-7 intramuscular injections in single doses with an interval of 48 hours. The course dose depends on the clinical picture. The duration of the course is 8-12 days. With prolonged and prophylactic use, the interval between Neovir injections is 3-7 days.

For HIV infection, injection solution is used as part of a combination therapy. The course of treatment consists of 10 intramuscular injections of 250 mg with an interval between injections of 48 hours. After the course of therapy, take a break for 2 months. The number of repeated courses is not limited.

Solution for intramuscular injection is transparent, greenish-yellow in color.

1 ml sodium oxodihydroacridinyl acetate 125 mg

Excipients: sodium citrate - 2.5 mg, citric acid monohydrate - 0.5-1.5 mg (up to pH 7.5-8.3), water d / i - up to 1 ml.

• severe renal failure (CC less than 30 ml / min);

• autoimmune diseases;

• pregnancy;

• lactation (breastfeeding);

• childhood;

• hypersensitivity to the components of the drug.

• Use with caution in elderly patients.

pharmachologic effect

Immunostimulating drug. Possesses antiviral activity against DNA and RNA genomic viruses. It has a pronounced anti-chlamydial effect. The activity of the drug is associated with its ability to induce the formation in the body of high titers of endogenous interferons, especially interferon alpha.

IM administration of Neovir at a dose of 250 mg according to the detected serum concentrations of interferon is equivalent to the introduction of 6-9 million IU of recombinant interferon alpha.

Neovir activates bone marrow stem cells, T-lymphocytes and macrophages. Shows immunomodulatory activity, normalizing the balance between subpopulations of T-helper and T-suppressor cells. In a number of diseases, Neovir is able to reduce the production of tumor necrosis factor in the body (HIV infection, herpes) and activate natural killer cells (in tumor diseases). Significantly increases the activity of polymorphonuclear leukocytes.

In HIV infection, Neovir has an immunomodulatory effect: it increases the absorption activity of blood serum, increases the ability of leukocytes to synthesize interferon alpha, and stimulates the formation of reactive oxygen species by phagocytes.

The peak of interferon activity in the blood and tissues is observed several hours after the administration of Neovir and lasts for 16-20 hours.

Pharmacokinetics

Suction

When administered intramuscularly, the bioavailability of Neovir is more than 90%. After the introduction of Neovir at a dose of 100-500 mg, Cmax in blood plasma is reached in 15-30 minutes and is 8.3 ?g / ml. After 5 hours, only insignificant concentrations of the active substance are determined, and after 6 hours the drug is not detected in the blood plasma.

In 15-30 minutes after the administration of Neovir in the plasma titers of serum interferon begin to increase. Revealed 2 peaks in the content of interferons in plasma: 70 IU / ml after 1.5-2 hours and 110 IU / ml after 8-10 hours, after which they begin to decrease. After 24 hours, the concentration of serum interferons remains high enough, and returns to the initial values ??after 46-48 hours.

Metabolism and excretion

Not metabolized. T1 / 2 is 1 hour. It is excreted by the kidneys unchanged.

Side effect

General reactions: low-grade fever, allergic reactions.

Local reactions: local quickly passing soreness at the injection site.

Application during pregnancy and lactation

The drug is contraindicated for use during pregnancy and lactation (breastfeeding).

Application for impaired renal function

The drug is contraindicated in severe renal failure (CC less than 30 ml / min).

special instructions

In case of poor tolerance or pain at the site of the intramuscular injection of the drug, it is recommended to inject Neovir together with 2 ml of 0.25-0.5% novocaine solution.

Overdose

Data on overdose of the drug Neovir are not provided.

Drug interactions

During clinical trials and the use of the drug in clinical practice, there were no cases of incompatibility or potentiation of the drug's action when interacting with other drugs.

There is no information on the physical and chemical incompatibility of Neovir with other drugs.