Ornidazole tablets 500mg, No. 10

• Trichomoniasis

• amebiasis (intestinal and non-intestinal forms, including amoebic dysentery and amoebic liver abscess),

• giardiasis,

• prevention of postoperative complications (especially during operations on the colon or in gynecology).

For oral administration, depending on the indications, treatment regimen and patient's body weight, a single dose for adults varies from 500 mg to 2 g; for children weighing up to 35 kg, the daily dose is 20-40 mg / kg. The frequency of admission and the duration of use are set individually.

Film-coated tablets

1 tab. ornidazole

• Diseases of the central nervous system,

• acute neurological diseases,

• I trimester of pregnancy,

• lactation period,

• hypersensitivity to ornidazole.

pharmachologic effect

Antiprotozoal agent derived from 5-nitroimidazole. It is believed that the mechanism of action is associated with a violation of the structure of the DNA of sensitive microorganisms. It is active against Trichomonas vaginalis, Giardia lamblia, Entamoeba histolytica, as well as against some anaerobic bacteria (including Bacteroides spp., Clostridium spp., Fusobacterium and anaerobic cocci). T1 / 2 of ornidazole is higher than that of metronidazole.

Pharmacokinetics

After oral administration, absorption from the gastrointestinal tract is high. The time to reach Cmax is 1-2 hours. Plasma protein binding is 15% or more. Penetrates the BBB. T1 / 2 - about 13 hours. It is excreted in the form of metabolites by the kidneys (60-70%) and with feces (20-25%), unchanged - about 5%.

Side effect

From the digestive system: possible - nausea, heartburn, dizziness, drowsiness, skin rash. From the nervous system: possible - headache, dizziness, impaired consciousness, tremor, muscle stiffness, impaired coordination of movements, seizures, sensory or mixed peripheral neuropathy, nausea, vomiting, diarrhea.

Application during pregnancy and lactation

Contraindicated in the first trimester of pregnancy, during lactation. During pregnancy, use is possible only for absolute indications if the expected benefit to the mother outweighs the potential risk to the fetus.

Application in children

Application is possible according to the dosage regimen.

special instructions

Does not inhibit alcohol dehydrogenase, therefore it is not incompatible with alcohol.

Drug interactions

It potentiates the action of indirect anticoagulants, increases the duration of action of vecuronium bromide.