Phosphogliv forte capsules, No. 50

Viral hepatitis (acute and chronic), fatty liver degeneration (hepatosis), other liver damage (medicinal, alcoholic, toxic), liver cirrhosis, intoxication, psoriasis, neurodermatitis, eczema.

It is taken orally during meals with a small amount of liquid.
Adults 1-2 capsules 3 times a day, children over 12 years old - 1 capsule 3 times a day.

Active substances : Phospholipids (Lipoid PPL-400) - 400.0 mg [in terms of 100% substance (main component - phosphatidylcholine 73-79%)] - 300.0 mg
Sodium glycyrrhizinate (trisodium salt of glycyrrhizic acid) - 65.0 mg
Excipients : butylhydroxytoluene - 0.1 mg, ethyl alcohol 'luxury' or 'extra' (ethanol) - 12 mg, sunflower oil or corn oil - 22.9 mg
Capsule shell composition
Hard gelatin capsules No. 0
Body and lid: titanium dioxide, iron dye red oxide, iron dye black oxide, iron dye yellow oxide, gelatin.

Hypersensitivity to the components of the drug, pregnancy, lactation, children under 12 years of age.

Tradename:

PhosphoglivЃ forte

Chemical name:

phospholipids + trisodium salt of glycyrrhizic acid.

Grouping name:

phospholipids + glycyrrhizic acid.

Dosage form:

capsules

Composition for one capsule.

Active substances : Phospholipids (Lipoid PPL-400) - 400.0 mg [in terms of 100% substance (main component - phosphatidylcholine 73-79%)] - 300.0 mg
Sodium glycyrrhizinate (trisodium salt of glycyrrhizic acid) - 65.0 mg
Excipients : butylhydroxytoluene - 0.1 mg, ethyl alcohol 'luxury' or 'extra' (ethanol) - 12 mg, sunflower oil or corn oil - 22.9 mg
Capsule shell composition
Hard gelatin capsules No. 0
Body and lid: titanium dioxide, iron dye red oxide, iron dye black oxide, iron dye yellow oxide, gelatin.

Description : hard gelatin capsules No. 0; the body and cap of the capsule are brown.
The contents of the capsule are an oily paste-like mass from light yellow to orange-brown in color with a weak specific odor.

Pharmacotherapeutic group:

hepatoprotective agent

ATX code : [ј05¬ј]

Pharmacological properties

Combined remedy. It has membrane stabilizing, hepatoprotective and antiviral effects.
Phosphatidylcholine (the main component of phospholipids) is the main structural element of cellular and intracellular membranes, is able to restore their structure and function in case of damage, providing a cytoprotective effect.
It normalizes protein and lipid metabolism, prevents the loss of enzymes and other active substances by hepatocytes, restores the detoxification function of the liver, inhibits the formation of connective tissue, reducing the risk of liver fibrosis and cirrhosis.
Glycyrate (glycyrrhizic acid and salts) has an anti-inflammatory effect, inhibits the reproduction of viruses in the liver and other organs by stimulating the production of interferons, increasing phagocytosis, and increasing the activity of natural killer cells. It has a hepatoprotective effect due to its antioxidant and membrane stabilizing activity. It potentiates the action of endogenous glucocorticosteroids, providing anti-inflammatory and anti-allergic effects in non-infectious liver damage.
In case of skin lesions due to the membrane-stabilizing and anti-inflammatory action of the components, it limits the spread of the process and contributes to the regression of the disease.

Pharmacokinetics
The components of the drug are well absorbed in the intestine, both as a whole molecule and as bioactive products of their hydrolysis (unsaturated fatty acids, choline, glycyrrhetic acid), which, after being absorbed through the intestinal wall, easily penetrate into the liver, lungs, skin and other organs.

Indications for use

Viral hepatitis (acute and chronic), fatty liver degeneration (hepatosis), other liver damage (medicinal, alcoholic, toxic), liver cirrhosis, intoxication, psoriasis, neurodermatitis, eczema.

Contraindications

Hypersensitivity to the components of the drug, pregnancy, lactation, children under 12 years of age.

Method of administration and dosage

It is taken orally during meals with a small amount of liquid.
Adults 1-2 capsules 3 times a day, children over 12 years old - 1 capsule 3 times a day.

Interaction with other medicinal products

Not described.

Side effect

With increased individual sensitivity, a skin rash may appear, which disappears after the drug is discontinued.
Rarely, when the daily doses are exceeded, there may be: sodium and fluid retention, which is manifested by peripheral edema and increased blood pressure, hypokalemia. When these symptoms appear, depending on their severity, it is necessary to reduce the dose of the drug and / or prescribe spironolactone at 50-100 mg per day.

Overdose

Not checked.

Release form

Capsules.
30, 50, 100, 200 or 300 capsules in plastic containers with high-pressure polyethylene or propylene lids or polymer cans, sealed with tamper-evident lids with a moisture-absorbing insert.
10 capsules in a blister strip made of polyvinyl chloride film and aluminum foil.
1 container or 2, 3, 5 blisters together with instructions for use are placed in a carton box.

Storage conditions

Store at a temperature not exceeding 25 ? C.
Keep out of the reach of children.

Shelf life

3 years.
Do not use the drug after the expiration date.

Vacation conditions

On prescription.