Pirantel oral suspension 250mg / 5ml, 15ml

- ascariasis;
- hookworm;
- non-kotorosis;
- enterobiasis;
- trichocephalosis.

With ascariasis and enterobiasis, with mixed invasions by these helminths - by mouth, once, after breakfast at the rate of 10 mg / kg.
Adults and children over 12 years old - 750 mg, with a body weight of more than 75 kg - 1 g.
Children from 6 months to 2 years old - 125 mg, 2 - 6 years old - 250 mg, 6 - 12 years old - 500 mg. To avoid self-invasion, the course may be repeated after 3 weeks. after the first dose.
In case of hookworm infection , a combination of noncatorosis with ascariasis or with other combined helminthic lesions, it is prescribed for 3 days at 10 mg / kg / day or for 2 days at 20 mg / kg / day.
With isolated ascariasis - 5 mg / kg once.

Active ingredient:
Pyrantel pamoate 735 mg is equivalent to pyrantel base 250 mg.
Excipients:
Sorbic acid, sucrose, xanthan gum, methyl parahydroxybenzoate, propyl parahydroxybenzoate, sorbitol 70% solution, polysorbate 80, chocolate flavor S 2761 (composition: propylene glycol, water, caramel color, natural, identical to natural substances, and artificial aromatics) ї(Composition: propylene glycol, water, caramel color, natural, identical to natural and artificial aromatic substances), purified water.

- hypersensitivity to pyrantel;
- myasthenia gravis (treatment period).
It is prescribed with caution for liver failure and for children under 6 months of age.

Trade name of the drug: Pirantel

International non-proprietary name:

pyrantel

Dosage form:

suspension for oral administration.

Composition for 5 ml of suspension:
Active ingredient:
Pyrantel pamoate 735 mg is equivalent to 250 mg pyrantel base.
Excipients:
Sorbic acid, sucrose, xanthan gum, methyl parahydroxybenzoate, propyl parahydroxybenzoate, sorbitol 70% solution, polysorbate 80, chocolate flavor S 2761 (composition: propylene glycol, water, caramel color, natural, identical to natural substances, and artificial aromatics) ї(Composition: propylene glycol, water, caramel color, natural, identical to natural and artificial aromatic substances), purified water.

Description
Homogeneous yellow suspension.

Pharmacotherapeutic group:

Anthelmintic agent.

ATX code: –02——01.

Pharmacological action
Pharmacodynamics
Anthelmintic drug with a broad spectrum of action. Causes neuromuscular blockade of sensitive helminths. Active against Enterobius vermicularis, Ascaris lumbriocoides, Ancylostoma duodenale, Necator americanus, Trichostrongylus orientalis, Trichostrongylus colubriformis. Acts on both sexually mature and immature individuals of both sexes, does not affect larvae in the stage of migration.
Pharmacokinetics
Absorption:
After oral administration, pyrantel is poorly absorbed from the gastrointestinal tract (GIT). After taking a single dose of 10 mg / kg of body weight, the plasma concentration of pyrantel is 0.005-0.13 ?g / ml for 1-3 hours.
Distribution
There are no data on the distribution of pyrantel in tissues and biological fluids of the body (theoretically, the absorption of the active substance is minimal), as well as on the possibility of excreting the active substance in breast milk.
Metabolism and excretion
Pirantel, absorbed into the systemic circulation, is partially metabolized in the liver to N-methyl-1,3-propanediamine. 93% of the dose taken is excreted unchanged in the feces, about 7% - in the urine unchanged or as a metabolite.

Indications
- ascariasis;
- hookworm;
- non-kotorosis;
- enterobiasis;
- trichocephalosis.

Contraindications
- hypersensitivity to pyrantel;
- myasthenia gravis (treatment period).
It is prescribed with caution for liver failure and for children under 6 months of age.

Pregnancy and lactation
The use of the drug during pregnancy and lactation (breastfeeding) is possible only if the intended benefit to the mother outweighs the potential risk to the fetus or child.

Dosage and administration
For ascariasis and enterobiasis, with mixed infestations by these helminths - orally, once, after breakfast at the rate of 10 mg / kg.
Adults and children over 12 years old - 750 mg, with a body weight of more than 75 kg - 1 g.
Children from 6 months to 2 years old - 125 mg, 2 - 6 years old - 250 mg, 6 - 12 years old - 500 mg. To avoid self-invasion, the course may be repeated after 3 weeks. after the first dose.
In case of hookworm infection , a combination of noncatorosis with ascariasis or with other combined helminthic lesions, it is prescribed for 3 days at 10 mg / kg / day or for 2 days at 20 mg / kg / day.
With isolated ascariasis - 5 mg / kg once.

Side effect
From the gastrointestinal tract and liver: possible nausea, vomiting, diarrhea, stomach pain; rarely - an increase in the activity of hepatic transaminases.
From the side of the central nervous system (CNS): rarely - headache, dizziness, drowsiness, insomnia, weakness; in some cases - hearing impairment, hallucinations, confusion, paresthesia.
Others: skin rash, fever.

Overdose
Currently, no cases of overdose have been reported. If necessary, symptomatic therapy is performed.

Drug interactions
When used together with piperazine adipate, Pirantel acts antagonistically (this combination is not recommended).
Increases the concentration of theophylline in plasma.

Special instructions
In case of enterobiasis, simultaneous treatment of all persons living together should be carried out. After completion of treatment, it is necessary to conduct a control study of feces for the presence of parasite eggs.
There are no data available on the impact on driving of vehicles and maintenance of mechanical equipment.

Release form
Oral suspension 250 mg / 5 ml.
15 ml of the drug in a dark glass bottle with a screw cap and a measuring cap. Each bottle is placed in a cardboard box with instructions for use.

Shelf life is
3 years.
Do not use the drug after the expiration date indicated on the package.

Storage conditions
In a dry, dark place at a temperature not exceeding 25 o—.
Keep out of the reach of children.

Terms of dispensing from pharmacies
Prescription.