Polyoxidonium suppositories 12mg, No. 10

Pills

In adults and adolescents over 12 years of age - treatment and prevention of infectious and inflammatory diseases (viral, bacterial and fungal etiology) that are not amenable to standard therapy both in the stage of exacerbation and in the stage of remission:

In complex therapy:

acute and chronic recurrent infectious and inflammatory diseases of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear;

allergic diseases complicated by recurrent bacterial, fungal and viral infections (including hay fever, bronchial asthma);

rehabilitation often and for a long time (more than 4Ц5 times a year) of sick persons.

As monotherapy:

prevention of recurrent herpes infection;

seasonal prevention of exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear;

in immunocompromised persons - prevention of influenza and other acute respiratory infections in the pre-epidemic period;

correction of secondary immunodeficiencies arising from aging or exposure to adverse factors.

Lyophilisate for solution for injection and topical use

Correction of immunity in adults and children from 6 months.

In adults in complex therapy:

chronic recurrent infectious and inflammatory diseases that are not amenable to standard therapy in the stage of exacerbation and in the stage of remission;

acute and chronic viral and bacterial infections (including urogenital infectious and inflammatory diseases);

tuberculosis;

acute and chronic allergic diseases (including hay fever, bronchial asthma, atopic dermatitis), complicated by chronic recurrent bacterial and viral infections;

in oncology during and after chemotherapy and radiation therapy - a decrease in the immunosuppressive, nephro- and hepatotoxic effects of drugs;

activation of regenerative processes (fractures, burns, trophic ulcers);

rheumatoid arthritis, long-term treatment with immunosuppressants;

rheumatoid arthritis complicated by acute respiratory illness or acute respiratory viral infection;

prevention of postoperative infectious complications;

prevention of influenza and acute respiratory diseases.

In children in complex therapy:

acute and chronic inflammatory diseases caused by pathogens of bacterial, viral, fungal infections (including ENT organs - sinusitis, rhinitis, adenoiditis, hypertrophy of the pharyngeal tonsil, acute respiratory viral infection);

acute allergic and toxic-allergic conditions;

bronchial asthma complicated by chronic respiratory tract infections;

atopic dermatitis complicated by a purulent infection;

intestinal dysbiosis (in combination with specific therapy);

rehabilitation of patients who are often and for a long time;

prevention of influenza and acute respiratory diseases.

Suppositories

In adults and children over 6 years old.

In complex therapy for the correction of immune deficiency:

chronic recurrent infectious and inflammatory diseases that are not amenable to standard therapy both in the stage of exacerbation and in the stage of remission;

acute viral, bacterial and fungal infections;

inflammatory diseases of the urogenital tract, incl. urethritis, cystitis, pyelonephritis, prostatitis, salpingo-oophoritis, endomyometritis, colpitis, cervicitis, cervicosis, bacterial vaginosis (including viral etiology);

various forms of tuberculosis;

allergic diseases complicated by recurrent bacterial, fungal and viral infections (including hay fever, bronchial asthma, atopic dermatitis);

rheumatoid arthritis, long-term treatment with immunosuppressants;

rheumatoid arthritis complicated by acute respiratory illness or acute respiratory viral infection;

activation of regenerative processes (fractures, burns, trophic ulcers);

rehabilitation often and for a long time (more than 4Ц5 times a year) of sick persons;

during and after chemotherapy and radiation therapy of tumors;

decrease in the nephro- and hepatotoxic effect of drugs.

As monotherapy:

prevention of recurrent herpes infection;

seasonal prevention of exacerbations of chronic foci of infections, prevention of influenza and acute respiratory diseases in the pre-epidemic period;

correction of secondary immunodeficiencies arising from aging or exposure to adverse factors.

Pills.

Orally and sublingually, 20-30 minutes before meals, daily 1, 2 or 3 times a day.

Adults - at doses of 12 or 24 mg, adolescents - at a dose of 12 mg. The method and dosage regimen is determined by the doctor, depending on the diagnosis, severity and severity of the process.

Sublingually:

- with inflammatory processes of the oropharynx (bacterial, viral and fungal nature): 1 table. 2 times a day every 12 hours for 10-14 days. In severe forms of herpes and fungal infections of the oral cavity - 1 table. 3 times a day every 8 hours for 15 days;

- for chronic diseases of the paranasal paranasal sinuses and chronic otitis media: 1 table. 2 times a day every 12 hours, for 5-10 days;

- for chronic tonsillitis: 1 tab. 3 times a day every 8 hours for 10-15 days;

- for chronic diseases of the upper respiratory tract: adults - 2 tables. (24 mg) 2 times a day, adolescents - 1 table. (12 mg) 2 times a day, after 12 hours, for 10-14 days;

- for the prevention of influenza and acute respiratory infections: immunocompromised persons suffering from acute respiratory infections more than 4 times a year, in the pre-epidemic period for adults - 2 tables. (24 mg), adolescents - 1 table. (12 mg) 2 times a day every 12 hours, for 10-15 days.

Orally:

- for chronic diseases of the upper respiratory tract: adults - 2 tables. (24 mg) 2 times a day every 12 hours, adolescents - 1 table. (12 mg) 2 times a day, after 12 hours, for 10-14 days.

Lyophilisate for solution for injection and topical use

Adults

Parenteral, intranasal. The methods of application are chosen by the doctor depending on the severity of the disease and the age of the patient.

In / m or / in (drip): the drug is prescribed for adults in doses of 6-12 mg 1 time per day every day, every other day or 1-2 times a week, depending on the diagnosis and severity of the disease.

For intramuscular administration, the contents of the ampoule or vial are dissolved in 1.5-2 ml of 0.9% sodium chloride solution or water for injection. For intravenous (drip) administration, the drug is dissolved in 2 ml of 0.9% sodium chloride solution, Gemodez-N, Reopoliglyukin or 5% dextrose solution, then sterilely transferred into a vial with the indicated solutions with a volume of 200-400 ml.

The prepared solution for parenteral administration cannot be stored.

Intranasally: a dose of 6 mg is dissolved in 1 ml (20 drops) of distilled water, 0.9% sodium chloride solution or boiled water at room temperature.

Recommended treatment regimens for adults

Parenteral:

- in acute inflammatory diseases: 6 mg daily for 3 days, then every other day with a general course of 5-10 injections;

- for chronic inflammatory diseases: 6 mg every other day 5 injections, then 2 times a week with a course of at least 10 injections;

- for tuberculosis: 6Ц12 mg 2 times a week with a course of 10Ц20 injections;

- in patients with acute and chronic urogenital diseases: 6 mg every other day with a course of 10 injections in combination with chemotherapy;

- for chronic recurrent herpes: 6 mg every other day with a course of 10 injections in combination with antiviral drugs, interferons and / or inducers of interferon synthesis;

- for the treatment of complicated forms of allergic diseases: 6 mg each, a course of 5 injections - 2 first injections daily, then every other day. In acute allergic and toxic-allergic conditions, inject 6-12 mg IV in combination with other antiallergic drugs;

- with rheumatoid arthritis: 6 mg every other day - 5 injections, then 2 times a week with a course of at least 10 injections.

In cancer patients:

- before and during chemotherapy to reduce the immunosuppressive, hepato- and nephrotoxic effects of chemotherapeutic agents - 6-12 mg every other day with a course of at least 10 injections, then the frequency of administration is determined by the doctor depending on the tolerance and duration of chemotherapy and radiation therapy;

- for the prevention of the immunosuppressive effect of the tumor, for the correction of immunodeficiency after chemotherapy and radiation therapy, after surgical removal of the tumor, long-term use of the drug PolyoxidoniumЃ (from 2-3 months to 1 year) is indicated - 6-12 mg 1-2 times a week.

In patients with acute renal failure: prescribed no more than 2 times a week.

Intranasally prescribed 6 mg / day for the treatment of acute and chronic infections of ENT organs, to enhance the regenerative processes of the mucous membranes, to prevent complications and recurrence of diseases, to prevent influenza and acute respiratory infections. 3 drops in each nasal passage after 2-3 hours (3 times a day) for 5-10 days.

Children

Parenteral, intranasal, sublingual. The methods of application are chosen by the doctor depending on the diagnosis, the severity of the disease, the age and body weight of the patient.

Parenterally, the drug is prescribed to children from 6 months of age at a dose of 3 mg (intramuscular or intravenous drip 0.1-0.15 mg / kg) daily, every other day or 2 times a week in a course of 5-10 injections (dose calculation is indicated in table).

For intramuscular administration, the drug is dissolved in 1 ml of water for injection or 0.9% sodium chloride solution.

For intravenous drip administration, the drug is dissolved in 1.5Ц2 ml of sterile 0.9% sodium chloride solution, Reopoliglukin, Gemodez-N or 5% dextrose solution, sterile transferred into a bottle with the indicated solutions with a volume of 150Ц250 ml.

Intranasal and sublingual: daily at a daily dose of 0.15 mg / kg for 5-10 days. The drug is administered in 1-3 drops in one nasal passage or under the tongue every 2-3 hours. To prepare a solution for intranasal and sublingual use, a dose of 3 mg is dissolved in 1 ml (20 drops), a dose of 6 mg - in 2 ml of distilled water, 0.9% sodium chloride solution or boiled water at room temperature. One drop of the prepared solution (50 ?l) contains 0.15 mg of PolyoxidoniumЃ, which is prescribed per 1 kg of the child's body weight.

Store the solution for sublingual and intranasal use in the refrigerator for no more than 7 days. Before use, the pipette with the solution must be warmed to room temperature (20Ц25 ? C).

Recommended treatment regimens for children:

- in acute inflammatory diseases: 0.1 mg / kg every other day with a course of 5-7 injections;

- for chronic inflammatory diseases: 0.15 mg / kg 2 times a week with a course of up to 10 injections;

- for acute allergic and toxic-allergic conditions: intravenous drip at a dose of 0.15 mg / kg in combination with antiallergic drugs;

- for the treatment of complicated forms of allergic diseases in combination with basic therapy: i / m, 0.1 mg / kg, a course of 5 injections with an interval of 1-2 days.

Intranasally, 1-3 drops are injected into one nasal passage after 2-3 hours (2-4 times a day). For intranasal and sublingual administration, the calculation of the daily dose for children is presented in the table.

Sublingual: for all indications - daily at a daily dose of 0.15 mg / kg for 10 days, for the treatment of intestinal dysbiosis for 10Ц20 days. Drop 1-3 drops under the tongue after 2-3 hours.

Suppositories

Rectally or vaginally 1 supp. (6 and 12 mg) once a day. The method and dosage regimen is determined by the doctor depending on the diagnosis, severity and severity of the process. PolyoxidoniumЃ can be applied rectally or vaginally daily, every other day or 2 times a week.

PolyoxidoniumЃ, suppositories 12 mg is used in adults rectally or vaginally.

Rectally: 1 supp. 1 time per day. (after cleansing the intestines).

Vaginally: for gynecological diseases, 1 supp. Once a day (at night), it is inserted into the vagina in the supine position.

PolyoxidoniumЃ, 6 mg suppositories are used: in children over 6 years of age, rectally - 1 suppository each. 1 time per day (after cleansing the intestines), in adults - rectally (after cleansing the intestines) or vaginally (into the vagina in the supine position) as a maintenance dose - 1 supp. Once a day (at night).

The standard application scheme for PolyoxidoniumЃ is 1 supp. (6 or 12 mg) 1 time per day, daily for 3 days, then every other day with a course of 10Ц20 supp. If necessary, the course of treatment is repeated after 3-4 months.

For patients receiving long-term immunosuppressive therapy, cancer patients with an acquired immune system defect - HIV, exposed to radiation, long-term maintenance therapy from 2-3 months to 1 year with PolyoxidoniumЃ is indicated (adults - 12 mg, children over 6 years old - 6 mg 1-2 times a week).

Recommended schemes of use as part of complex therapy:

- for chronic infectious and inflammatory diseases: in the stage of exacerbation - according to the standard scheme, in the stage of remission - 1 supp. after 1-2 days, the general course is 10-15 supp.;

- in acute infectious processes and to activate regenerative processes (fractures, burns, trophic ulcers): 1 supp. daily, course of treatment - 10-15 supp.;

- for tuberculosis: according to the standard scheme, the course of treatment is at least 15 supp., then it is possible to use maintenance therapy - 2 supp. a week with a course of 2-3 months;

- against the background of chemotherapy and radiation therapy of tumors: 1 supp. every day 2-3 days before the start of the course of therapy, then the frequency of administration of suppositories is determined by the doctor depending on the tolerance and duration of chemotherapy and radiation therapy;

- for rehabilitation often (more than 4-5 times a year) and long-term ill persons and with rheumatoid arthritis: 1 supp. every other day, the course of treatment is 10-15 supp.

- for the correction of secondary immunodeficiencies, incl. arising from aging: 1 supp. (12 mg) 2 times a week, course - at least 10 supp. 2-3 times a year.

As monotherapy:

- for seasonal prevention of exacerbations of chronic foci of infection, prevention of recurrent herpes infection: every other day for adults - 6-12 mg, for children - 6 mg. Course - 10 supp.

- for the correction of secondary immunodeficiencies, the prevention of influenza and acute respiratory infections: according to the standard scheme.

- for gynecological diseases (rectally or vaginally): according to the standard scheme.

Pills

1 tablet contains active substance: azoxymer bromide 12 mg mixed with excipients: mannitol, povidone, betacarotene - to obtain a mixture of 18 mg

excipients: lactose monohydrate - 185 mg; potato starch - 45 mg; stearic acid - 2 mg

Lyophilisate for solution for injection and topical use

1 amp. or vial active substance: azoximer bromide 3 mg 6 mg

excipients: mannitol; povidone; betacarotene - up to 4.5 (for a dose of 3 mg) or 9 (for a dose of 6 mg) mg

—уппозитории дл¤ вагинального или ректального применени¤

1 супп.активное вещество: азоксимера бромид6 мг 12 мг

вспомогательные вещества: маннитол; повидон; бетакаротен Ч до 9 (дл¤ дозы 6 мг) или 18 (дл¤ дозы 12 мг) мг основа: масло какао бобов Ч до получени¤ суппозитори¤ массой 1,3 г

ќбщие дл¤ всех лекарственных форм

повышенна¤ индивидуальна¤ чувствительность;

беременность (клинический опыт применени¤ отсутствует);

период лактации.

?л¤ таблеток дополнительно

?етский возраст до 12 лет.

?л¤ суппозиториев дополнительно

?етский возраст до 6 лет.

— осторожностью

ќбщие дл¤ всех лекарственных форм Ч остра¤ почечна¤ недостаточность.

?л¤ таблеток дополнительно Ч непереносимость лактозы, дефицит лактазы, глюкозогалактозна¤ мальабсорбци¤.

?л¤ лиофилизата дл¤ приготовлени¤ раствора дл¤ инъекций и местного применени¤ (дополнительно) Ч детский возраст до 6 мес (клинический опыт применени¤ ограничен).

‘армакологитческое действие

јзоксимера бромид обладает комплексным действием: иммуномодулирующим, детоксицирующим, антиоксидантным, противовоспалительным. јзоксимера бромид повышает резистентность организма в отношении локальных и генерализованных инфекций. ¬осстанавливает иммунные реакции при вторичных иммунодефицитных состо¤ни¤х, вызванных различными инфекци¤ми, травмами, ожогами, злокачественными новообразовани¤ми, осложнени¤ми после хирургических операций, применением химиотерапевтических средств, в т.ч. цитостатиков, стероидных гормонов. ќсновой механизма иммуномодулирующего действи¤ азоксимера бромида ¤вл¤етс¤ пр¤мое воздействие на фагоцитирующие клетки и естественные киллеры, а также стимул¤ци¤ антителообразовани¤. јзоксимера бромид снижает воспалительную реакцию посредством нормализации синтеза про- и противовоспалительных цитокинов. ?етоксикационные и антиоксидантные свойства азоксимера бромида определ¤ютс¤ структурой и высокомолекул¤рной природой препарата. јзоксимера бромид блокирует растворимые токсические вещества и микрочастицы, обладает способностью выводить из организма токсины, соли т¤желых металлов, ингибирует перекисное окисление липидов. јзоксимера бромид хорошо переноситс¤, не обладает митогенной, поликлональной активностью, антигенными свойствами, не оказывает аллергизирующего, мутагенного, эмбриотоксического, тератогенного и канцерогенного действи¤.

ѕобочное действие

ќчень редко: местные реакции в виде покраснени¤, отека, зуда перианальной зоны, вагинального зуда в св¤зи с индивидуальной чувствительностью к компонентам препарата.

ѕрименение при беременности и кормлении грудью

ѕротивопоказано применение при беременности и в период грудного вскармливани¤.  линический опыт применени¤ отсутствует. ¬ экспериментальных исследовани¤х препарата ѕолиоксидонийЃ у животных не вы¤влено эмбриотоксического и тератогенного действи¤, вли¤ни¤ на развитие плода.

ѕрименение при нарушени¤х функции печени

—осторожностью следует назначать препарат пациентам с нарушением функции печени (клинические исследовани¤ не проводились).

ѕрименение при нарушени¤х функции почек

— осторожностью следует назначать препарат пациентам с нарушением функции почек (клинические исследовани¤ не проводились). ѕротивопоказано применение препарата при острой почечной недостаточности.

ѕрименение у детей

ѕротивопоказано применение препарата в детском возрасте до 6 лет (клинический опыт применени¤ отсутствует). ѕрепарат в форме суппозиториев 12 мг противопоказан в возрасте до 18 лет.

ќсобые указани¤

ѕри необходимости прекращени¤ терапии препаратом отмену можно проводить сразу. ¬ случае пропуска разовой дозы препарата необходимо прин¤ть его как можно раньше, но если наступило врем¤ приема следующей дозы, дозу на прием не следует увеличивать. Ќе следует примен¤ть препарат при наличии визуальных признаков его непригодности (дефект упаковки, изменение цвета суппозиториев). ѕри развитии аллергической реакции пациент должен прекратить применение препарата и обратитьс¤ к врачу.

»спользование в педиатрии

?ет¤м и подросткам в возрасте от 6 до 18 лет суппозитории ввод¤т только ректально.

¬ли¤ние на способность к управлению транспортными средствами и механизмами

The use of PolyoxidoniumЃ does not affect the ability to drive vehicles, maintain mechanisms and other types of work that require increased concentration of attention and speed of psychomotor reactions.

Overdose

Currently, no cases of overdose of PolyoxidoniumЃ have been reported.

Drug interactions

Azoximer bromide does not inhibit isoenzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6 of cytochrome P450, therefore the drug is compatible with many drugs, incl. with antibiotics, antiviral, antifungal and antihistamines, GCS and cytostatics.