Probifor powder for oral administration 5 doses., No. 10 sachets .

• acute and chronic intestinal infections of a bacterial and viral nature (salmonellosis, shigellosis, enterocolitis caused by pathogenic representatives of the genus Enterobacteriaceae or staphylococci, rotavirus infection) or of unknown etiology, foodborne infections;

• diarrhea syndrome of various etiologies;

• chronic nonspecific inflammatory diseases of the digestive tract, accompanied by a violation of the microflora and inhibition of the reparative processes of the intestinal mucosa (gastroduodenitis, pancreatitis, proctosigmoiditis, colitis / including ulcerative /);

• dysbacteriosis of various etiologies, incl. developed against the background and after taking antibiotics, cytostatic, radiation therapy; complicating the course of viral hepatitis, liver cirrhosis, intestinal diverticulosis of various localization;

• irritable bowel syndrome, other functional intestinal disorders; syndrome of impaired intestinal absorption of various etiologies;

• newborns (including premature babies) with a burdened premorbid background, starting from the period of stay in the maternity hospital, to improve the course of the adaptation period, as well as with severe dysbacteriosis;

• in the complex treatment of patients (including newborns) with secondary immunodeficiency conditions, with severe infectious-inflammatory and purulent-septic diseases (including sepsis, peritonitis); with skin diseases (atopic dermatitis, streptoderma, eczema);

• in the complex treatment of acute respiratory viral infections and influenza;

• in the complex treatment of surgical patients (including trauma patients) for preoperative preparation and prevention of postoperative complications; with post-gastro-resection disorders and conditions after cholecystectomy;

• in the complex treatment of cancer patients during chemotherapy, radiation therapy, before and after surgical interventions:

• pregnant women in preparation for childbirth, caesarean section and in the postoperative period.

Inside, during meals, if necessary, regardless of the meal.

Before use, the powder is mixed with liquid food, preferably a fermented milk product, for newborns and infants - with mother's milk or formula for artificial feeding. You can mix the drug with 30-50 ml of boiled water at room temperature, while a cloudy suspension with particles of black sorbent is formed. The resulting aqueous suspension should be drunk without achieving complete dissolution.

The capsules are washed down with water. For children and patients who cannot swallow a whole capsule, it is opened, the contents of the capsule are taken in the same way as a powder.

Powder, capsules

Acute intestinal infection, food poisoning, diarrhea: children under 6 months - 1 pack. 2 times a day; over 6 months - 1 pack. 3-4 times a day (possibly with an interval of 2-3 hours), the course of treatment is 2-3 days, if symptoms persist, the course of treatment is extended to 4-5 days; from 5 to 7 years old - 1 caps. 3-4 times a day (possibly with an interval of 2-3 hours), the course of treatment is 2-3 days, if symptoms persist, the course of treatment is extended to 4-5 days; over 7 years old and adults - 2-3 packs / caps. 2 times a day, the course of treatment is 3-5 days.

Termination of diarrhea in the early stages of the disease: adults - 3 packs / caps. 2 times a day with an interval of 30-60 minutes. The dosage can be increased to 6 bags / caps. Once a day, the course of treatment is 1-3 days.

Chronic pathology of the gastrointestinal tract, irritable bowel syndrome: children from 5 years old - once 3 caps. during an evening meal; children and adults - 3 packs once. during an evening meal; adults - possibly 3 caps. once or 2 packs / caps. 2 times a day. The course of treatment is 5-15 days. In severe cases of the disease: children from 1 to 5 years old - up to 6 pack. in a day; children from 5 years old and adults - up to 6 packs / caps. per day, course - up to 30 days.

Comprehensive treatment of acute respiratory viral infections and influenza: children under 5 years of age from 1-2 days of illness - 1 pack. 3 times a day; children over 5 years old and adults from 1-2 days of illness - 1 pack./caps. 3 times a day, the course of treatment is 2 days.

Surgical patients, pregnant women in preparation for a caesarean section in order to reduce postoperative complications: before surgery, children under 5 years old - 1 pack. 3 times a day for 2-3 days; over 5 years old and adults - 1 pack. / caps. 3 times a day for 2-3 days; for persons suffering from intestinal dysbiosis, who received antibiotics and chemotherapy, the preoperative course is lengthened to 7 days; from 2-7 days after surgery, children under 5 years old - 1 pack., children over 5 years old and adults - 1 pack. / caps. 3 times a day for 2-3 days, according to indications - up to 7-10 days.

Dysbacteriosis of various etiologies, chronic intestinal infections, patients with immunodeficiency states, skin diseases, as well as an improvement in the course of the adaptation period in newborns (including premature babies): premature newborns - 1 pack. 1-2 times a day; full-term newborns and children under 3 years old - 1 pack each. 2 times a day; children from 3 to 5 years old - 1 pack. 3 times a day; from 5 to 7 years old - 1 pack. / caps. 3 times a day; over 7 years old and adults - 2-3 packs / caps. 2 times a day. The course of treatment is 7-10 days.

Oral powder

1 pack.

active substance: bifidobacteria sorbed on activated carbon at least 500 million CFU

excipient: lactose monohydrate - up to 0.85 g

• individual intolerance to the drug.

Clinical and pharmacological group: A drug that regulates the balance of intestinal microflora (probiotic)

Pharmaco-therapeutic group: MIBP-eubiotic

pharmachologic effect

A drug of biological origin, which regulates the balance of intestinal microflora, probiotic.

The antidiarrheal effect of the drug is due to the high concentration of bifidobacteria sorbed on particles of activated carbon, which are antagonists of a wide range of pathogenic (including Shigella spp., Salmonella spp., Staphylococcus aureus) and opportunistic microorganisms (including Proteus spp., Klebsiella spp.).

The anti-infective effect of the drug is enhanced due to the sorption of bifidobacteria on coal particles, which leads to an accelerated normalization of the gastrointestinal tract microbiocenosis, activation of recovery processes in the mucous membranes and an increase in the anti-infective resistance of the body.

The anti-toxic effect of the drug is ensured by the rapid colonization of the intestine with microcolonies of bifidobacteria, the restoration of normal microflora, which prevents the penetration of toxins into the internal environment of the body and, being a natural biosorbent, accumulates in significant quantities from the outside or formed in the body toxic substances.

Bifidobacteria in high concentration activate the intestinal parietal digestion, the synthesis of vitamins and amino acids, enhance the protective function of the intestine and the body's immune defense.

Indications

• acute and chronic intestinal infections of a bacterial and viral nature (salmonellosis, shigellosis, enterocolitis caused by pathogenic representatives of the genus Enterobacteriaceae or staphylococci, rotavirus infection) or of unknown etiology, foodborne infections;

• diarrhea syndrome of various etiologies;

• chronic nonspecific inflammatory diseases of the digestive tract, accompanied by a violation of the microflora and inhibition of the reparative processes of the intestinal mucosa (gastroduodenitis, pancreatitis, proctosigmoiditis, colitis / including ulcerative /);

• dysbacteriosis of various etiologies, incl. developed against the background and after taking antibiotics, cytostatic, radiation therapy; complicating the course of viral hepatitis, liver cirrhosis, intestinal diverticulosis of various localization;

• irritable bowel syndrome, other functional intestinal disorders; syndrome of impaired intestinal absorption of various etiologies;

• newborns (including premature babies) with a burdened premorbid background, starting from the period of stay in the maternity hospital, to improve the course of the adaptation period, as well as with severe dysbacteriosis;

• in the complex treatment of patients (including newborns) with secondary immunodeficiency conditions, with severe infectious-inflammatory and purulent-septic diseases (including sepsis, peritonitis); with skin diseases (atopic dermatitis, streptoderma, eczema);

• in the complex treatment of acute respiratory viral infections and influenza;

• in the complex treatment of surgical patients (including trauma patients) for preoperative preparation and prevention of postoperative complications; with post-gastro-resection disorders and conditions after cholecystectomy;

• in the complex treatment of cancer patients during chemotherapy, radiation therapy, before and after surgical interventions:

• pregnant women in preparation for childbirth, caesarean section and in the postoperative period.

Dosage regimen

Probifor is taken orally during meals, if necessary - regardless of the meal.

The drug in the form of capsules is prescribed for adults and children aged 5 years and older . Capsules are taken with boiled water or fermented milk product.

The drug in powder form for oral administration is prescribed for adults and children of all age groups . Before use, the powder is mixed with liquid food, preferably with a fermented milk product, for newborns and infants - with mother's milk or formula for artificial feeding. The powder can be mixed with 30-50 ml of boiled water at room temperature, while a turbid suspension with sorbent particles is formed. The resulting aqueous suspension should be drunk without achieving complete dissolution.

Acute intestinal infection, food poisoning, diarrhea syndrome

Adults and children over 7 years old are prescribed 2-3 capsules or 2-3 sachets 2 times / day. The course of treatment is 3-5 days.

Children aged 5 to 7 years are prescribed 1 capsule 3-4 times / day (possibly with a short interval of 2-3 hours). The course of treatment is 2-3 days, while maintaining clinical symptoms, the course of treatment is increased to 4-5 days.

Children over 6 months old - 1 sachet 3-4 times / day (possibly with a short interval of 2-3 hours), children under 6 months old - 1 sachet 2 times / day. The course of treatment is 2-3 days, while maintaining clinical symptoms, the course of treatment is increased to 4-5 days.

For adults, to stop diarrhea in the early stages of the disease - 3 capsules or 3 sachets 2 times / day with an interval of 30 minutes to 1 hour. The dose can be increased to 6 capsules or 6 sachets at a time 1 time / day. The course of treatment is from 1 to 3 days.

Chronic gastrointestinal pathology and functional intestinal disorders

Adults and children over 5 years of age are prescribed 3 caps. or 3 sachets at a time 1 time / day during an evening meal; children under 5 years of age are prescribed 3 sachets 1 time / day during the evening meal. Adults can also be prescribed 2 capsules or 2 sachets 2 times / day.

The course of treatment is 5-15 days.

In severe cases of the disease, the dose for adults and children over 5 years old can be increased to 6 capsules or 6 sachets per day; for children aged 1 year and older - up to 6 sachets per day. The course of treatment is increased to 30 days.

Dysbacteriosis of various etiologies, chronic intestinal infections, patients with immunodeficiency states, with skin diseases, as well as to improve the course of the adaptation period in newborns

Adults and children over 7 years old are prescribed 2-3 capsules or 2-3 sachets 2 times / day; children aged 5-7 years - 1 caps. 3 times / day, at the age of 3-7 years - 1 sachet 3 times / day; full-term newborns and children under the age of 3 years - 1 sachet 2 times / day; premature newborns - 1 sachet 1-2 times / day.

The course of treatment is 7-10 days.

As part of the complex therapy of ARVI and influenza

Adults, elderly patients, children over 5 years of age are prescribed from 1-2 days of illness, 1 capsule or 1 sachet 3 times / day; children under 5 years old - 1 sachet 3 times / day. The course of treatment is 2 days.

Surgical patients, pregnant women in preparation for a caesarean section in order to reduce postoperative complications

Before surgery - 1 capsule or 1 sachet 3 times / day for 2-3 days; for patients with intestinal dysbiosis who received antibiotics and chemotherapy, the preoperative course is extended to 7 days.

From 2-7 days after surgery - 1 capsule or 1 sachet 3 times / day for 2-3 days, according to indications - 7-10 days.

Side effect

When used according to indications in recommended doses, the side effect of the drug has not been established.

Contraindications for use

• individual intolerance to the drug.

Application during pregnancy and lactation

The drug is approved for use during pregnancy and lactation (breastfeeding).

Application in children

The drug is prescribed for children according to indications and in recommended doses.

Use in elderly patients

The drug is prescribed to elderly patients according to indications and in recommended doses.

special instructions

The drug should be used with caution in case of lactase deficiency.

Overdose

An overdose of the drug Probifor is impossible due to the lack of cumulative action and excessive accumulation in the intestine.

Drug interactions

When taken simultaneously with vitamins (especially group B), the effect of the drug is enhanced.

When taken with antibiotics, the therapeutic efficacy of the drug may decrease.

Storage conditions

Packages should be stored at a temperature not exceeding 10 ? C. The lower temperature limit is not limited. Transportation is carried out at a temperature not exceeding 10 ? —; transportation is allowed at temperatures up to 20 ? — for no more than 10 days. The capsules should be stored between 2 ? and 10 ? C.

Shelf life

Expiration date - 1 year.

The drug should be kept out of the reach of children.

Terms of sale

The drug is approved for use as a means of OTC.