Pulmamag 100ml
DESCRIPTION
Pulmamag is a suspension for injection for the treatment of bacterial infections. In appearance, the drug is a viscous opaque liquid of yellow-lemon color.
COMPOSITION
Pulmamag in 1 ml contains 200 mg of azithromycin (in the form of a dihydrate), 2 mg of meloxicam, as well as excipients: aluminum stearate, diglyceryl isostearyl succinate, butylhydroxytoluene, butylhydroxyanisole, propylene glycol dicaprylocaprate.
PHARMACOLOGICAL PROPERTIES
Pulmamag is a complex drug containing a broad-spectrum bacteriostatic antibiotic from the group of macrolides-azalides and meloxicam, which belongs to the non-steroidal anti-inflammatory drugs of the oxicam group.
Azithromycin has a bactericidal / bacteriostatic effect on gram-negative (Actinobacillus lignieresi, Haemophilus spp, Moraxella spp, Bordetella spp, Campilobacter spp, Legionella pneumophila, Salmonella spp, Escherichia spp) and gram-positive bacteria (Listerlocus spp, Staploccus spp. pneumonia.Streptococcus pyogenes, Enterococcus faecalis, Erysipelothrix insidiosa and some anaerobic bacteria: (Clostridium perfringens, Fusobacterium spp, Pasteurella haemolytica, Pasteurella mannheimia, Pasteurella multocida, Myxoplusia spp. .).
The mechanism of action of azithromycin is associated with inhibition of protein biosynthesis by the ribosomes of bacteria, as a result of which the formation of peptide bonds between amino acids and the peptide chain is disrupted.
Azithromycin exhibits a postantibiotic effect - persistent inhibition of the vital activity of bacteria after short-term contact with an antibacterial drug. The effect is based on irreversible changes in the ribosomes of the microorganism, resulting in a persistent block of translocation. Due to this, the general antibacterial effect of the drug is enhanced and prolonged, remaining for the period necessary for the re-synthesis of new functional proteins of the microbial cell.
The mechanism of action of meloxicam is to suppress the production of cyclooxygenase (COX) in the arachidonic acid cycle. Meloxicam in therapeutic doses inhibits mainly cyclooxygenase-P, under the action of which the synthesis of inflammatory prostaglandins (PGE I and PGE2) occurs, causing inflammation and edema, thereby providing an anti-inflammatory and antipyretic effect, does not affect cyclooxygenase-I, minimizing the development of side effects. effects such as bleeding, ulceration, and renal dysfunction.
After intramuscular administration of the drug to cattle and pigs, more than 98% of meloxicam binds to blood plasma proteins and is concentrated in inflamed tissues.
The drug in therapeutic doses is well tolerated by animals, does not have a local irritant, as well as embryotoxic, teratogenic, mutagenic and sensitizing effects.
Pulmamag, according to the degree of impact on the body, belongs to low-hazard substances (hazard class 4 according to GOST 12.1.007-76).
PURPOSE
The drug is used in cattle and small ruminants, as well as in pigs and dogs for the treatment of bacterial infections of the respiratory system, digestive and genitourinary systems, infections of the skin and soft tissues, accompanied by inflammatory processes and caused by microorganisms sensitive to azithromycin. The drug is used for the treatment of necrobacteriosis, pig erysipelas, spirochetosis and mycoplasma infections, as well as an antipyretic agent for diseases accompanied by fever and depression.
DOSAGE AND APPLICATION
The drug is administered intramuscularly. Before starting work, shake the bottle with the drug thoroughly to distribute the particles evenly.
Depending on the severity of the disease, the drug is used in large and small ruminants, as well as pigs and dogs once a day (with an interval of 24 hours) for 3 to 4 days at a dose of 0.5 ml per 20 kg of animal weight.
SPECIAL INSTRUCTIONS
When working with PulmamagВ®, you should follow the general rules of personal hygiene and safety measures provided for when working with medicines. Do not drink, smoke or eat while working with the medicinal product. At the end of work, hands should be washed with warm water and soap.
Vials from under the medicinal product must not be used for household purposes, they must be disposed of with household waste.
In case of accidental contact of the drug with the skin or mucous membranes of the eye, they must be rinsed with plenty of water. In case of allergic reactions or accidental ingestion of the drug into the human body, you should immediately contact a medical institution (you should have instructions for use of the drug or a label with you).
The use of the drug does not exclude the use of other drugs. In combination therapy with tetracyclines and chloramphenicol, synergism is enhanced. Lincosamides reduce the therapeutic efficacy of azithromycin. The drug should not be administered concurrently with other non-steroidal anti-inflammatory drugs, glucocorticoids, diuretics and anticoagulants. It is forbidden to mix the drug in the same syringe with other drugs. Absolutely not compatible with heparin. Azithromycin therapy against the background of cardiac glycosides increases the toxicity of the latter.
The peculiarities of the action of the drug during its first use and when it is canceled have not been established.
CONTRAINDICATIONS
Contraindications for the use of the drug are lactation period, renal and hepatic failure, severe forms of allergic diseases and individual intolerance to azithromycin, meloxicam and / or other components of the drug.
It is forbidden to use the drug in animals during lactation. For pregnant animals and young animals, the drug is prescribed with caution under the supervision of a veterinarian.
SIDE EFFECTS
When using the drug Pulmamag in accordance with this instruction, side effects and complications in animals, as a rule, are not observed. At the site of drug administration, tissue edema may occur, which spontaneously quickly passes and therefore does not require treatment. In rare cases, allergic reactions are possible, in the event of which the drug is canceled, and antihistamine and symptomatic therapy is prescribed.
The use of the drug in animals in a state of dehydration, hypovolemia and hypotension is potentially dangerous due to the possible toxic effect of meloxicam on the kidneys.
SHELF LIFE AND STORAGE
The shelf life of the medicinal product, subject to storage conditions, is 3 years from the date of production. After the first opening of the bottle, the drug can be used within 7 days, subject to the rules of asepsis and storage in a refrigerator at a temperature of 2 В° C to 8 В° C. It is prohibited to use the drug after the expiration date.
Store the medicinal product in the manufacturer's sealed packaging in a place protected from direct sunlight, separately from food and feed, at a temperature of 5 В° C to 25 В° C.
PACKAGING
Pulmamag is produced packaged in 100 ml in glass bottles of appropriate capacity, sealed with rubber stoppers, reinforced with aluminum caps. Each consumer package is supplied with instructions for use.
Specifications
Bonus points
0
KolVUP
45
Manufacturer
Mosagrogen
Temperature regime
from +5 to +25
Teaser
for the treatment of bacterial infections