Revalgin tablets, No. 20

• Weak or moderate pain syndrome with spasms of smooth muscles of internal organs - renal and biliary colic, intestinal spasms, dysmenorrhea and other spastic conditions of internal organs;

• for short-term symptomatic treatment for headaches, migraine pains, joint pains, neuralgia, sciatica, myalgia;

• as an adjuvant, it can be used to reduce pain after surgical and diagnostic interventions;

• to reduce elevated body temperature in case of colds and infectious and inflammatory diseases.

Inside, after eating, adults and adolescents over 15 years old - 1-2 tables. 2-3 times a day for 5 days (no more). The daily dose is 6 tablets. (no more). An increase in the daily dose of the drug or the duration of treatment is possible only under the supervision of a physician.

Children: 6Ц8 years old - 1/2 tab., 9Ц12 years old - 3/4 tab., 13Ц15 years old - 1 tab. 2-3 times a day. In children, the drug is used only as directed by a doctor. Other dosage regimens are possible only after consulting a doctor.

Pills

1 tab.

active substance:

metamizole 500 mg

fenpiverinium bromide 0.1 mg

pitofenone hydrochloride 5 mg

excipients: starch; lactose; MCC; colloidal silicon dioxide; magnesium stearate; talc

• Severe liver or kidney dysfunction;

• genetic absence of glucose-6-phosphate dehydrogenase;

• tachyarrhythmia;

• angle-closure glaucoma;

• hypertrophy of the prostate with a tendency to urinary retention;

• gastrointestinal obstruction;

• megacolon;

• diseases of the blood system;

• collaptoid states;

• I trimester and the last 6 weeks of pregnancy;

• lactation period;

• hypersensitivity to pyrazolone derivatives and other components of the drug.

• The tablets are not used for children under 5 years of age.

pharmachologic effect

Spasmodic analgesic. The drug contains the non-narcotic analgesic metamizole sodium (analgin), the myotropic antispasmodic agent pitofenone hydrochloride and the anticholinergic agent fenpiverinium bromide.

Metamizole is a pyrazolone derivative. It has analgesic, antipyretic and anti-inflammatory effects.

Pitofenone, like papaverine, has a direct myotropic effect on the smooth muscles of the internal organs and causes its relaxation.

Fenpiverinium, due to its anticholinergic action, has an additional relaxing effect on smooth muscles.

The combination of the three components of the drug leads to a mutual enhancement of their pharmacological action, expressed in pain relief, relaxation of smooth muscles, and a decrease in elevated body temperature.

Side effect

In therapeutic doses, the drug is usually well tolerated.

Sometimes allergic reactions are possible (skin rash, itching, very rarely - anaphylactic shock).

In isolated cases - a burning sensation in the epigastric region, dry mouth, headache.

Dizziness, decreased blood pressure, tachycardia, cyanosis are possible.

With prolonged use - cases of violations of the blood system (thrombocytopenia, leukopenia, agranulocytosis).

With a tendency to bronchospasm, it is possible to provoke an attack.

All side effects should be reported to your doctor.

Application during pregnancy and lactation

Contraindication: I trimester and the last 6 weeks of pregnancy; lactation period.

Application for violations of liver function

Contraindication: severe liver dysfunction.

Application for impaired renal function

Contraindication: severe renal dysfunction.

Application in children

In children, the drug is used only as directed by a doctor. The tablets are not used for children under 5 years of age.

special instructions

The drug should be used with caution and under the supervision of a physician in patients with impaired liver and / or kidney function, with a tendency to hypotension, bronchospasm, and also with increased individual sensitivity to NSAIDs or non-narcotic analgesics.

With prolonged (more than a week) use, it is necessary to monitor the peripheral blood picture and indicators of the functional state of the liver.

Sometimes metamizole metabolites can stain urine red.

Overdose

In case of an overdose of the drug, the following symptoms may be observed: vomiting, a feeling of dry mouth, changes in sweating, impaired accommodation, arterial hypotension, drowsiness, confusion, impaired liver and kidney function, convulsions.

Treatment is symptomatic.

Drug interactions

The simultaneous use of Revalgin with other non-narcotic analgesics can lead to mutual enhancement of toxic effects.

Tricyclic antidepressants, oral contraceptives, allopurinol disrupt the metabolism of metamizole in the liver and increase its toxicity.

Barbiturates, phenylbutazone and other inducers of liver microsomal enzymes weaken the effect of metamizole.

Simultaneous use with cyclosporine reduces the level of the latter in the blood.

Sedatives and tranquilizers enhance the analgesic effect of Revalgin.

If necessary, the simultaneous use of these and other drugs, you should consult your doctor.