Sirdalud MR capsules 6mg, No. 30

• Spastic state of skeletal muscles caused by neurological diseases (multiple sclerosis, chronic myelopathy, stroke, degenerative diseases of the spinal cord).

• Painful spasm of skeletal muscles caused by damage to the spine (cervical and lumbar syndromes) or arising after surgery (for a herniated disc or osteoarthritis of the hip).

To stop painful skeletal muscle spasm, use 2-4 mg 3 times / day; in severe cases, it is additionally recommended to take 2-4 mg at night. For spastic muscle conditions caused by neurological diseases, the initial dose is 6 mg / day in 3 divided doses. The dose is gradually increased by 2-4 mg / day every 3-7 days. The optimal therapeutic effect is usually achieved at a dose of 12-24 mg / day, divided into 3-4 doses. Do not exceed a dose of 36 mg / day.

Modified release hard gelatin capsules, size 2, with a white opaque lid and a white opaque body, gray lettering 'Sirdalud' on the lid, '6 mg' gray lettering on the body; the contents of the capsules are round white or almost white pellets.

1 caps.

tizanidine hydrochloride 6.864 mg,?

which corresponds to the content of tizanidine base 6 mg

Excipients: ethylcellulose - 1 mg, shellac - 4 mg, talc - 18.736 mg, sugar spheres - 155.4 mg, titanium dioxide - 1.26 mg, gelatin - 61.74 mg.

Hypersensitivity to tizanidine.

pharmachologic effect

Muscle relaxant of central action. Reduces the increased tone of skeletal muscles, relieves their spasm; reduces muscle resistance during passive movements, increases the strength of voluntary contractions. The muscle relaxant effect of tizanidine is probably due to the inhibition of spinal polysynaptic reflexes, which is associated with a decrease in the release of excitatory amino acids from the presynaptic terminals of spinal interneurons, as well as the stimulation of ?2-adrenergic receptors. Tizanidine does not affect the transmission of excitation in neuromuscular synapses.

Side effect

When using tizanidine in relatively small doses, in rare cases, drowsiness, fatigue, dizziness, dry mouth, nausea, and a slight decrease in blood pressure are observed; in higher doses - these effects occur more often and are more pronounced, in addition, insomnia, muscle weakness, bradycardia, an increase in serum transaminase activity are possible.

Application for violations of liver function

Use with caution in patients with impaired liver function.

Application for impaired renal function

Use with caution in patients with impaired renal function.

special instructions

Use with caution in patients with impaired liver and kidney function.

Influence on the ability to drive vehicles and use mechanisms

At the beginning of treatment, if drowsiness occurs, activities requiring a high concentration of attention, rapid psychomotor reactions should be avoided.

Drug interactions

With simultaneous use with antihypertensive drugs (including diuretics), severe arterial hypotension and bradycardia may develop.

With the simultaneous use of ethanol, drugs with a sedative effect, the sedative effect is enhanced.