Structum capsules 500mg, No. 60

• Osteoarthritis;

• intervertebral osteochondrosis.

Inside with water. Adults and adolescents from 15 years of age are prescribed 1 g / day - 2 caps. 250 mg or 1 caps. 500 mg 2 times a day. The recommended duration of the initial course of treatment is 6 months, the period of action of the drug after its cancellation is 3-5 months, depending on the location and stage of the disease, the duration of repeated courses of treatment is set by the doctor.

Capsules

1 caps.

active substance:

chondroitin sodium sulfate 250/500 mg

excipient: talc - 5/10 mg composition of the capsule shell (body and caps): indigo carmine; titanium dioxide; gelatin

• Hypersensitivity to the components of the drug;

• children under 15 years of age (due to the lack of accurate data).

pharmachologic effect

Structum affects metabolic processes in hyaline and fibrous cartilage, reduces degenerative processes in the cartilage tissue of joints, stimulates the biosynthesis of glycosaminoglycans. Slows down the resorption of bone tissue and reduces calcium loss, accelerates the processes of bone tissue regeneration. Treatment with Structum reduces pain and improves the mobility of the affected joints. The therapeutic effect lasts a long time after the end of the course of therapy.

Pharmacokinetics

Absorption and distribution

After taking the drug inside, more than 70% of chondroitin sulfate is absorbed from the gastrointestinal tract. After a single dose at an average therapeutic dose, Cmax in blood plasma is achieved after 3-4 hours, in synovial fluid - after 4-5 hours.

The bioavailability of the drug is 13%. Chondroitin sulfate accumulates in the synovial fluid.

Withdrawal

It is excreted by the kidneys.

Side effect

From the digestive system: rarely - nausea, vomiting. Allergic reactions: rarely - urticaria, erythema, pruritus.

Application during pregnancy and lactation

Structum is not recommended to be prescribed during pregnancy and lactation (breastfeeding) due to the lack of sufficient clinical data.

Application in children

Contraindicated in children and adolescents under 15 years of age.

special instructions

The drug is prescribed with caution in case of bleeding or a tendency to bleeding.

Overdose

Symptoms: rarely - nausea, vomiting, diarrhea, with prolonged use in excessively high doses (more than 3 g / day), hemorrhagic rashes are possible.

Treatment: carrying out symptomatic therapy.

Drug interactions

With simultaneous use with Structum, it is possible to enhance the action of indirect anticoagulants, antiplatelet agents and fibrinolytics.