Triazavirin capsules 250mg, No. 20

treatment of influenza in adults.

If necessary, combine with taking symptomatic agents.

Triazavirin is administered orally with or without food.

Therapeutic doses

The drug should be taken no later than the 2nd day from the onset of the disease (the onset of clinical symptoms), 1 capsule (250 mg) 3 times a day (daily dose - 750 mg) for 5 days. If necessary, treatment can be continued for up to 7 days.

Hard gelatin capsules No. 1, yellow body and red cap; the contents of the capsules are microcrystalline powder or granules of yellow or yellow-green color.

1 caps. triazavirin 250 mg

Excipients: calcium stearate - 2 mg.

• hypersensitivity to drug components;

• pregnancy;

• breastfeeding period;

• children under 18 years of age (efficacy and safety have not been determined);

• renal / hepatic impairment (efficacy and safety not determined).

pharmachologic effect

The active substance of the drug Triazavirin is a synthetic analogue of the bases of purine nucleosides (guanine) with a pronounced antiviral effect. Possesses a wide spectrum of antiviral activity against RNA-containing viruses.

The main mechanism of action of the drug Triazavirin is inhibition of the synthesis of viral RNA and the replication of genomic fragments.

Pharmacokinetics

After oral administration, it is rapidly absorbed in the gastrointestinal tract. Cmax is achieved on average after 1-1.5 hours. Cmax with the recommended dosage regimen averages 4.8 ?g / ml. The AUC (area under the concentration-time pharmacokinetic curve) of blood is 12.8 ?g / h? Ml. T1 / 2 - 1-1.5 hours. The kidneys are excreted unchanged from 15 to 45% of the drug. The average calculated clearance is 246 ml / min.

Side effect

Possibly: allergic reactions.

From the digestive system: dyspeptic disorders (flatulence, diarrhea, nausea, vomiting).

If any of the side effects indicated in the instructions are aggravated, or you notice any other side effects that are not indicated in the instructions, inform your doctor.

Application during pregnancy and lactation

The use of the drug during pregnancy has not been studied.

The use of the drug during lactation has not been studied, therefore, if it is necessary to use the drug during lactation, breastfeeding should be discontinued.

Application for violations of liver function

Contraindicated in liver failure.

Application for impaired renal function

Contraindicated in renal failure.

Application in children

Contraindicated in children under 18 years of age.

special instructions

Influence on the ability to drive vehicles and use mechanisms

Has not been studied.

Overdose

Symptoms: nausea, vomiting, dyspeptic disorders, stomach pain.

Treatment: symptomatic therapy.

If these symptoms appear, you must stop taking the drug.

Drug interactions

Interaction with analogs of purine and pyrimidine bases during anticancer therapy may lead to an increase in the toxicity of the drug. With simultaneous use with ribavirin, a dose reduction of ribavirin is required.

The medicine is available with a prescription. You can book the drug online and pick up the order at a convenient pharmacy by paying for the purchase upon receipt.