trypsin, pancreatin, Rutozyd, Hymotrypsyn, Bromelayn, lipase, amylase, trypsin | Wobenzym tablets coated with solution-solution of 800 pcs.

Latin name

Wobenzym

Release form

Enteric-coated tablets of red-orange color, round, biconvex, with a smooth surface, with a characteristic odor, fluctuations in the color intensity of the outer shell from red-orange to red are allowed.



packaging 800 pcs - bottles of high density polyethylene.

Pharmacological action

Combined drug. It is a combination of highly active enzymes of plant and animal origin. It has immunomodulatory, anti-inflammatory, fibrinolytic, decongestant, antiplatelet and secondary analgesic effects.

Wobenzym has a positive effect on the course of the inflammatory process, limits the pathological manifestations of autoimmune and immunocomplex processes, and positively affects the immunological reactivity of the body. It stimulates and regulates the functional activity of macrophage monocytes, natural killer cells, stimulates antitumor immunity, cytotoxic T-lymphocytes, and phagocytic cell activity.

Under the influence of Wobenzym, the number of circulating immune complexes decreases and membrane deposits of immune complexes are eliminated from the tissues.

Wobenzym reduces plasma cell interstitial infiltration. It increases the elimination of protein detritus and fibrin deposits in the inflammation zone, accelerates the lysis of toxic metabolic products and dying tissues, improves the resorption of hematomas and edema, and normalizes the permeability of blood vessels.

Wobenzym reduces thromboxane concentration and platelet aggregation. Regulates the adhesion of blood cells, increases the ability of red blood cells to change their shape, regulating their plasticity, normalizes the number of normal discocytes (platelets) and reduces the total number of activated platelets, normalizes blood viscosity, reduces the total number of microaggregants, thus improving the microcirculation and rheological properties of the blood, as well as supplying tissues with oxygen and nutrients.

Wobenzym normalizes lipid metabolism, reduces the synthesis of endogenous cholesterol, increases HDL, reduces the level of atherogenic lipids, improves the absorption of polyunsaturated fatty acids.

Wobenzym increases the effectiveness of antibiotic therapy, increasing the concentration of antibiotics in the blood plasma and the focus of inflammation, and also reduces the side effects of antibiotics (dysbiosis).

Wobenzym reduces the severity of side effects associated with the use of hormonal drugs (including hypercoagulation).

Wobenzym regulates the mechanisms of non-specific protection (production of interferons), thereby exhibiting antiviral and antimicrobial effects.

Indications

As a part of complex therapy:

thrombophlebitis (including acute superficial vein thrombophlebitis), postphlebitis syndrome, obliterating endarteritis and atherosclerosis of the arteries of the lower extremities, lymphatic edema, prevention of recurrent siblitis, fibrititis, fibritis sexually transmitted

chronic genital infections, gestosis, mastopathy, adnexitis, to reduce the frequency and severity of the side effects of hormone replacement therapy in gynecology

angina pectoris, subacute stage of myocardial infarction (to improve the rheological properties of blood)

sinusitis, bronchitis, pneumonia

pancreatitis, hepatitis

pyelonephritis diabetes, diabetes pyelonephritis, diabetes autoimmune thyroiditis

rheumatoid arthritis, reactive arthritis, ankylosing spondylitis

atopic dermatitis, acne

multiple sclerosis

uveitis, iridocyte um hemophthalmus,

use in ophthalmic surgery treatment of post-operative complications (inflammation, thrombosis, swelling), adhesive disease, post-traumatic and lymphatic edema, plastic and reconstructive surgery

injuries, fractures, distortion, damage to the ligamentous apparatus, bruises, chronic post-traumatic processes, inflammation of the soft tissues, burns, injuries in sports medicine.

Prevention:

microcirculatory disorders, post-stress disorders, as well as disruption of the adaptation mechanisms of

side effects of hormone replacement therapy, hormonal contraception

during surgical interventions to prevent infectious complications and adhesive disease.

Wobenzym is recommended for the prevention of infectious complications and improve the quality of life during chemotherapy or radiation therapy of viral infections and their complications.

Contraindications

diseases associated with an increased likelihood of bleeding (including hemophilia, thrombocytopenia)

hemodialysis

children under 5 years old

individual intolerance to the drug.

Use during pregnancy and lactation

Wobenzym should be prescribed during pregnancy and lactation with caution and under the supervision of a physician.

Composition

1 tab.

pancreatin 345 prot.ed.Ph.Eur.

papain 90 units of FIP

rutoside 50 mg

bromelain 225 units of FIP

lipase 34 units of FIP

amylase 50 units of FIP

chymotrypsin 300 sdlp ,

magnesium stearate,

stearic acid,

purified water,

silicon dioxide colloidal,

talc, sucrose.

Composition of tablet shells:

sucrose,

talc,

copolymer of methacrylic acid and methyl methacrylate,

shellac,

titanium dioxide,

clay white,

dye yellow-orange (Е110),

dlp 4p, reddlp 4pkp, srdlpp 4p, red macrogol 6000,

triethyl citrate,

vanillin,

wax bleached,

carnauba wax.

Dosage and administration

Set individually depending on the severity of the disease.

Adults, depending on the activity and severity of the disease, are prescribed in a dose of 3 to 10 tablets. 3 times / day In the first 3 days of taking the drug, the recommended dose is 3 tablets. 3 times / day

With an average activity of the disease, the drug is prescribed in a dose of 5-7 tab. 3 times / day for 2 weeks. In the future, the dose should be reduced to 3-5 tablets. 3 times / day The course is 2 weeks.

With a high activity of the disease, the drug is prescribed in a dose of 7-10 tab. 3 times / day for 2-3 weeks. In the future, the dose should be reduced to 5 tab. 3 times / day The course is 2-3 months.

In chronic long-term illnesses, Wobenzym can be used according to indications in courses of 3 to 6 months or more.

In order to increase the effectiveness of antibiotics and the prevention of dysbiosis, Wobenzym should be used throughout the entire course of antibiotic therapy in a dose of 5 tablets. 3 times / day After stopping the course of antibiotic therapy to restore intestinal microflora, Wobenzym should be prescribed 3 tablets. 3 times / day for 2 weeks.

During radiation and chemotherapy, Wobenzym should be used in a dose of 5 tablets. 3 times / day until the completion of the course of radiation and chemotherapy in order to prevent infectious complications, improve tolerance to basic therapy and improve the quality of life.

For prophylactic purposes, Wobenzym is prescribed 3 tab. 3 times / day for 1.5 months with a repetition of the course 2-3 times a year.

Children aged 5-12 years are prescribed in a daily dose at the rate of 1 tab. per 6 kg of body weight. For children over 12 years of age, the drug is prescribed according to the scheme intended for adults. The duration of treatment is determined individually.

The drug should be taken at least 30 minutes before meals, without chewing, washed down with water (200 ml).

Side effects

Wobenzym is generally well tolerated by patients.

In most cases, side effects, withdrawal syndrome, addiction were not observed even with prolonged use in high doses.

In some cases: slight changes in the consistency and smell of feces, urticaria (disappear when the dose is reduced or the drug is withdrawn).

Patient should be warned that that with the appearance of other adverse reactions, it is recommended to cancel the drug and consult a doctor.

Overdose

No cases of overdose with Wobenzim have been reported.

Storage conditions

List B.

The drug should be stored out of the reach of children, in a dry place at a temperature of 15 ° to 25 РC.

Expiration

2.5 years.

Terms of sale from

drugstores Over-the-counter

Dosage form

dosage form

tablets

Mukos Pharma, Germany