Tsitovir-3 capsules, No. 48

Inside, 30 minutes before meals.

Single dose for adults and children over 6 years old - 1 capsule.

For treatment, 1 capsule is prescribed 3 times / day for 4 days.

For prevention:

-in direct contact with a patient with influenza and other acute respiratory viral infections - 1 capsule 3 times / day for 4 days;

- during the period of an epidemic rise in the incidence of influenza and other acute respiratory viral infections - 1 capsule 1 time / day for 12 days.

Prophylactic courses, if necessary, are repeated after 3 weeks (until the epidemic situation returns to normal).

Hard gelatin capsules, No. 3, with a white body and an orange cap; the contents of the capsules are white to yellow powder, odorless.

1 caps.

alpha glutamyl tryptophan sodium 0.5 mg

ascorbic acid 50 mg

bendazole hydrochloride 20 mg

Excipients: lactose monohydrate - 97.8 mg, calcium stearate - 1.7 mg.

The composition of the capsule shell: body: titanium dioxide - 2%, gelatin - up to 100%; cap: titanium dioxide - 2%, sunset yellow dye - 0.219%, azorubin dye - 0.0328%, gelatin - up to 100%.

• Hypersensitivity to the components of the drug;

• pregnancy;

• children under 6 years of age.

• With caution: during breastfeeding, use is possible if the intended benefit to the mother outweighs the potential risk to the child.

pharmachologic effect

The drug is a means of etiotropic and immunostimulating therapy, has an indirect antiviral effect against influenza A and B viruses, as well as other viruses that cause acute respiratory diseases.

Reduces the severity of the main clinical symptoms of influenza and SARS, and also reduces the duration of the disease and contributes to its uncomplicated course.

Increases the content of secretory immunoglobulin A (sIgA) in the mucous membrane of the nasopharynx - the entrance gate of infection, increasing the body's local immunoresistance to respiratory infections of viral and bacterial nature.

With a preventive action, the drug increases the potential metabolic activity of cells of innate immunity (neutrophilic granulocytes and monocytes), which, in the event of an infection, increases their ability to absorb and destroy bacterial and viral agents by increasing enzymatic (oxidative) activity, synthesis of cationic proteins and increasing the number of phagocytic cells. At the same time, the initial state of metabolic activity of cells of innate immunity, in the absence of infectious agents, does not change, being within normal values.

Bendazol induces the production of endogenous interferon in the body, has an immunomodulatory effect (normalizes the body's immune response). Enzymes, the production of which is induced by interferon in cells of various organs, inhibit viral replication.

Alpha-glutamyl-tryptophan (thymogen) is a synergist of the immunomodulatory action of bendazole, normalizing the T-cell link of immunity.

Ascorbic acid activates the humoral link of immunity, normalizes capillary permeability, thereby reducing inflammation; exhibits antioxidant properties, neutralizing oxygen radicals accompanying the inflammatory process; increases the body's resistance to infection.

Pharmacokinetics

Suction

when taken orally, the drug is completely absorbed from the gastrointestinal tract. Bioavailability of bendazole is about 80%, alpha-glutamyl-tryptophan is no more than 15%, ascorbic acid is up to 90%.

Metabolism and excretion

The metabolites of ascorbic acid and bendazole are excreted in the urine. Alpha-glutamyl-tryptophan is cleaved by peptidases into L-glutamic acid and L-tryptophan, which are used by the body in peptide synthesis.

Side effect

Possibly: allergic reactions, short-term decrease in blood pressure.

Application during pregnancy and lactation

The drug is contraindicated for use during pregnancy.

During breastfeeding, use is possible if the intended benefit to the mother outweighs the potential risk to the child.

Application in children

Contraindications: children under 6 years of age.

special instructions

Influence on the ability to drive vehicles and mechanisms

The drug does not affect the ability to drive vehicles and other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Overdose

Symptoms: short-term decrease in blood pressure in patients with vegetative vascular dystonia, the elderly.

Treatment: control of renal function, blood pressure and blood glucose concentration.

Drug interactions

The interaction of alpha-glutamyl-tryptophan with drugs has not been identified.

Bendazole prevents an increase in OPSS caused by the use of non-selective beta-blockers. Strengthens the hypotensive effect (lowering blood pressure) of antihypertensive and diuretic drugs. Phentolamine enhances the hypotensive effect of bendazole.

Ascorbic acid increases the concentration in the blood of antibacterial drugs of the tetracycline series and benzylpenicillin. Improves intestinal absorption of iron preparations. Reduces the effectiveness of heparin and indirect anticoagulants. Acetylsalicylic acid (ASA), oral contraceptives, fresh juices, and alkaline drinks reduce absorption and absorption. With simultaneous use with ASA, urinary excretion of ascorbic acid increases and ASA excretion decreases. ASA reduces the absorption of ascorbic acid by about 30%. Ascorbic acid increases the risk of crystalluria when using drugs containing ASA and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs with an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood.With simultaneous use, it reduces the chronotropic effect of isoprenaline. Reduces the therapeutic effect of antipsychotics (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants. Barbiturates and primidone increase the excretion of ascorbic acid in the urine.

Possible simultaneous use with antiviral drugs and symptomatic therapy for influenza and acute respiratory viral infections.

If the patient is taking the above drugs or other drugs, he should consult a doctor.