Zovirax Duo-Active cream 50mg + 10mg / g, 2 g

For external use only.

Adults and children over 12 years old

The drug should be applied 5 times a day (approximately every 4 hours), except at night. The drug is applied in a thin layer to the affected and adjacent areas of the skin.

It is important to start treatment of recurrent infection as early as possible, preferably in the prodromal period, that is, at the first appearance of nonspecific signs of infection (burning, tingling, feeling of tightness of the skin).

Duration of treatment is at least 5 days.

Do not use the drug for more than 5 days.

If the symptoms of the disease persist after 5 days of using the drug, you should consult a doctor.

In order to prevent deterioration of the condition and prevent the transmission of infection, it is necessary to wash your hands before and after applying the drug, do not rub or touch the affected skin with a towel.

1 g of cream contains:
Active substances: acyclovir 50 mg, hydrocortisone 10 mg
Excipients: liquid paraffin - 56.5 mg, soft white paraffin - 100 mg, isopropyl myristate - 150 mg, sodium lauryl sulfate - 8 mg, cetostearyl alcohol - 67.5 mg, poloxamer 188 - 10 mg, propylene glycol - 200 mg, citric acid monohydrate - 1.4 mg, sodium hydroxide - 0.6 mg qs until pH is reached, hydrochloric acid - qs until pH is reached, purified water - qs up to 1000 mg. '

• Hypersensitivity to acyclovir, valacyclovir, hydrocortisone and other components of the drug;

• skin lesions caused by other viruses, fungal, bacterial skin diseases, as well as parasitic skin infections;

• skin tumors, rosacea, acne vulgaris, perioral dermatitis;

• children under 12 years of age.

pharmachologic effect

The combined preparation contains acyclovir and hydrocortisone.

Acyclovir is active against Herpes simplex types 1 and 2, Varicella zoster virus, Epstein-Barr virus and cytomegalovirus. Thymidine kinase of cells infected with a virus through a series of sequential reactions actively converts acyclovir to mono-, di- and acyclovir triphosphate. The latter interacts with viral DNA polymerase and is embedded in DNA, which is synthesized for new viruses. Thus, 'defective' viral DNA is formed, which leads to suppression of replication of new generations of viruses.

Hydrocortisone is a weakly active glucocorticosteroid. When applied topically and locally, the therapeutic activity of hydrocortisone is due to its anti-inflammatory, antipruritic, antiallergic and antiexudative (due to the vasoconstrictor effect) action.

As a result of the combination of the antiviral effect of acyclovir and the anti-inflammatory effect of hydrocortisone, ZoviraxЃ Duo-Active prevents the formation of vesicular rash elements on the affected skin areas (when used in the prodromal period), and also shortens the healing time of already formed rash elements. The mechanism of action is due to the blocking of viral replication and inhibition of the development of an inflammatory reaction in the affected area of ??the skin, which leads to a decrease in the severity of symptoms of infection.

Pharmacokinetics

Absorption and distribution

With topical application of the drug, systemic absorption of acyclovir is minimal; hydrocortisone can penetrate through the stratum corneum of the epidermis, reaching its lower layers, is absorbed in insignificant amounts. When used in recommended doses, it does not suppress the hypothalamic-pituitary-adrenal system.

Side effect

Allergic reactions:

Very rarely - immediate type hypersensitivity reactions, including angioedema.

On the part of the skin and subcutaneous tissues:

Often - dryness, flaking of the skin;

Infrequently - short-term burning sensation, tingling sensation in the areas of application of the drug; itching;

Rarely - skin redness; changes in skin pigmentation; allergic dermatitis, often associated with a reaction to hydrocortisone or excipients.

Local reactions:

Rarely - symptoms of an inflammatory reaction (pain, swelling, redness, local increase in tissue temperature).

If any of the listed side effects occur, stop taking the drug and contact your doctor immediately.

Application during pregnancy and lactation

The use of ZoviraxЃ Duo-Active during pregnancy and during breastfeeding is not recommended, except when prescribed by a doctor (if the intended benefit to the mother outweighs the potential risk to the fetus and child).

Application in children

Contraindicated in children under 12 years of age.

special instructions

To achieve the maximum therapeutic effect and prevent the formation of vesicles (bubbles) on the skin, it is necessary to start using the drug when the first signs of the disease appear (burning, itching, tingling, feeling of tightness).

In case of severe manifestations of herpes infection of the skin of the lips, you should consult a doctor.

The cream can only be used for herpes of the skin of the lips. It is not recommended to apply the drug to the mucous membranes of the mouth and eyes, as well as to use a cream for the treatment of genital herpes.

Avoid getting the cream in the eyes.

Do not apply occlusive dressings, patches or special antiherpetic masking patches to the cream application site. Immunocompromised patients should follow the advice of a physician when treating any infectious disease. Since these patients are at high risk of developing resistance to acyclovir, they should not use this drug.

The preparation contains cetyl alcohol, which can cause local skin reactions such as contact dermatitis, and propylene glycol, which can cause skin irritation.

Influence on the ability to drive vehicles, mechanisms

ZoviraxЃ Duo-Active does not affect the performance of potentially hazardous activities that require special attention and quick reactions (driving a car and other vehicles, working with moving mechanisms, the work of a dispatcher and operator, etc.).

Overdose

In case of accidental ingestion or single use of the entire contents of the package, no adverse effects were observed. If you suspect an overdose, you should seek medical help.

Drug interactions

When applied externally, interactions with other drugs have not been identified.